Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles

Autor: Rebecca Pavlos, Elizabeth J. McKinnon, David A. Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Ryan Schutte, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Thomas Kaever, Paisley Myers, Ellen Speers, Stacy A. Malaker, Jeffrey Shabanowitz, Yuan Jing, Silvana Gaudieri, Donald F. Hunt, Mary Carrington, David W. Haas, Simon Mallal, Elizabeth J. Phillips

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediat

Externí odkaz: https://doaj.org/article/713379e67e8e4c309dc4c182e4231712

Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer.

Autor: Michael H Matho, Andrew Schlossman, Xiangzhi Meng, Mohammed Rafii-El-Idrissi Benhnia, Thomas Kaever, Mark Buller, Konstantin Doronin, Scott Parker, Bjoern Peters, Shane Crotty, Yan Xiang, Dirk M Zajonc

Publikováno v: PLoS Pathogens, Vol 11, Iss 9, p e1005148 (2015)

Vaccinia virus A33 is an extracellular enveloped virus (EEV)-specific type II membrane glycoprotein that is essential for efficient EEV formation and long-range viral spread within the host. A33 is a target for neutralizing antibody responses against

Externí odkaz: https://doaj.org/article/328f3bcaf2e84d4dba1ab57708d22e11

Structure–function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8

Autor: Dirk M. Zajonc, Shane Crotty, Yan Xiang, Jing Wang, Klaus Ley, Thomas Kaever, Zbigniew Mikulski, Xiangzhi Meng, Greg Miller, Matthias Hupfer, Michael H. Matho, Linda C. Hsieh-Wilson, Andrew Schlossman, Aruna Bitra, Bjoern Peters, Iuliia M. Gilchuk, Tzanko Doukov, James E. Crowe

Publikováno v: Journal of Biological Chemistry. 293:390-401

Vaccinia virus (VACV) envelope protein D8 is one of three glycosaminoglycan adhesion molecules and binds to the linear polysaccharide chondroitin sulfate (CS). D8 is also a target for neutralizing antibody responses that are elicited by the smallpox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c5a93dbc04fbeef3fa6b6d19571007
https://doi.org/10.1074/jbc.m117.814541

Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles

Autor: Abha Chopra, Simon Mallal, David M. Koelle, Jeffrey Shabanowitz, Søren Buus, Paisley T. Myers, Elizabeth J. Phillips, Yuan Jing, Alec J. Redwood, Austin W. Bracey, Susana Restrepo, Ellen Speers, Elizabeth McKinnon, Rebecca Pavlos, Silvana Gaudieri, Bjoern Peters, David A. Ostrov, Ryan J. Schutte, David W. Haas, Donald F. Hunt, Craig M. Rive, Mary Carrington, Thomas Kaever, Stacy A. Malaker

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Pavlos, R, McKinnon, E J, Ostrov, D A, Peters, B, Buus, S, Koelle, D, Chopra, A, Schutte, R, Rive, C, Redwood, A, Restrepo, S, Bracey, A, Kaever, T, Myers, P, Speers, E, Malaker, S A, Shabanowitz, J, Jing, Y, Gaudieri, S, Hunt, D F, Carrington, M, Haas, D W, Mallal, S & Phillips, E J 2017, ' Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles ', Scientific Reports, vol. 7, 8653 . https://doi.org/10.1038/s41598-017-08876-0

Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediated drug h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364358a2fa4d33d8cbb3b90ce82b8ba1
https://doi.org/10.1038/s41598-017-08876-0

Machine Learning Reveals a Non-Canonical Mode of Peptide Binding to MHC class II Molecules

Autor: Vanessa Isabell Jurtz, Alessandro Sette, Morten Nielsen, Bjoern Peters, Massimo Andreatta, Thomas Kaever

Publikováno v: Andreatta, M, Jurtz, V I, Kaever, T, Sette, A, Peters, B & Nielsen, M 2017, ' Machine Learning Reveals a Non-Canonical Mode of Peptide Binding to MHC class II Molecules ', Immunology, pp. 255-264 . https://doi.org/10.1111/imm.12763
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

MHC class II molecules play a fundamental role in the cellular immune system: they load short peptide fragments derived from extracellular proteins and present them on the cell surface. It is currently thought that the peptide binds lying more or les

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832040bcc903301dd989f97db8bd511d
https://orbit.dtu.dk/en/publications/26b90dac-837d-4feb-99b6-99d0304062ac