Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Thomas K. Takayama"'
Publikováno v:
International Journal of Cancer. 126:599-610
In prostate cancer, the mechanism by which the stromal cells surrounding the cancer epithelium become reactive and overproduce growth factors is unclear. Furthermore, the precise process of how these stromal cells stimulate the cancer epithelium is n
Publikováno v:
The Prostate. 69:727-736
BACKGROUND Prostate cancer progression is partly facilitated by tumor–stroma interactions. We recently reported that protease-activated receptors (PAR-1 and PAR-2) are overexpressed in prostate cancer, and PAR-1 expression in peritumoral stroma is
Publikováno v:
Molecular Cancer Research. 6:1043-1051
A major characteristic of prostate cancer is the elevation of serum levels of prostate-specific antigen (hK3) and hK2, which are tumor markers that correlate with advancing stages of disease. Including hK4, these three kallikrein serine proteases are
Publikováno v:
The Prostate. 68:1064-1075
BACKGROUND Benign prostatic hyperplasia (BPH) is characterized by abnormal epithelial and stromal proliferation causing urinary obstruction. Prostate growth is regulated by a variety of growth factors secreted from the stroma, including fibroblast gr
Autor:
Robert L. Vessella, Sarah Hawley, Thomas K. Takayama, Peter C. Black, Gregory J. Mize, Peter Karlin, Daniel L. Greenberg, Lawrence D. True
Publikováno v:
The Prostate. 67:743-756
BACKGROUND Although protease-activated receptors (PARs) have been described to play a role in different malignancies, their expression and biological activity in prostate cancer are mostly unknown. METHODS PAR expression in radical prostatectomy spec
Publikováno v:
Journal of Biological Chemistry. 272:21582-21588
The precursor or zymogen form of prostate-specific antigen (pro-PSA) is composed of 244 amino acid residues including an amino-terminal propiece of 7 amino acids. Recombinant pro-PSA was expressed in Escherichia coli, isolated from inclusion bodies,
Publikováno v:
Journal of Urology. 158:425-430
Purpose: We determined the success of early urethral realignment using magnetic urethral catheters.Materials and Methods: We retrospectively reviewed the records of 13 patients with complete urethral disruption treated with endourological realignment
Autor:
Paul H. Lange, Thomas K. Takayama
Publikováno v:
Urologic Clinics of North America. 21:687-700
A definitive conclusion about the value of ART is not possible from the data available: Both the methods of radiation therapy and the techniques in the diagnosis of locally persistent disease have evolved over the years. Currently, the data lead to t
Publikováno v:
Journal of Urology. 150:374-378
Prostate specific antigen (PSA) determinations after radical prostatectomy are valuable in detecting persistent disease. Previously, we determined that 0.4ng./ml. PSA was a reliable clinical threshold using the Hybritech Tandem-R PSA assay. Recently,
Autor:
Lawrence D. True, Alvin Y. Liu, Ricardo Zn Vêncio, Amber A Chambers, Laura E. Pascal, Emily S Liebeskind, Young Ah Goo, Thomas K. Takayama, Laura S. Page
Publikováno v:
BMC Cancer
BMC Cancer, Vol 9, Iss 1, p 317 (2009)
BMC Cancer, Vol 9, Iss 1, p 317 (2009)
Background The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. The tumor-associated stroma is marked by increased expression of CD90/T