Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas K. Shires"'
Publikováno v:
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 117:117-120
Ergothioneine (ERT), is a low molecular weight, sulfur-containing antioxidant occurring in up to millimolar amounts in mammalian tissues. Using an improved HPLC assay, ERT levels have been measured and compared in bovine and porcine eyes and erythroc
Publikováno v:
Brain Research Bulletin. 30:85-90
The vitreous is a neural extracellular space separated from the blood-vascular compartment by the blood-retinal barrier. Study of the appearance of serum proteins in this space have been carried out in rats with streptozotocin-induced diabetes mellit
Publikováno v:
Peptides. 13:671-675
Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was fo
Publikováno v:
Retina (Philadelphia, Pa.). 10(2)
Nonenzymatic glycosylation has been shown to affect collagen elsewhere in the body in diabetic patients. A fluorescent product of nonenzymatic glycosylation of protein was found to accumulate in the vitreous of rats 2 months after diabetogenic doses
Autor:
James C. Folk, M. Bridget Zimmerman, Harry W. Flynn, Thomas K. Shires, Jose S. Pulido, Michael H. Scott
Publikováno v:
Archives of Ophthalmology. 110:1683
To the Editor. —We read with interest the article by Campochiaro and Conway 1 as well as the subsequent related correspondence. 2,3 Part of the problem with the determination of aminoglycoside toxicity has been that toxic doses have been establishe
Autor:
Jose S. Pulido, Thomas K. Shires
Publikováno v:
American Journal of Ophthalmology. 109:493
Autor:
Laura K. Shawver, Thomas K. Shires
Publikováno v:
Life Sciences. 33:847-854
In a rabbit reticulocyte lysate cell-free system and using double antibody immunoprecipitation method, newly translated rat liver NADPH-cytochrome P-450 reductase (E.C. 1.6.2.4) was shown to be cleaved in the absence of exogenous membranes. Reductase
Autor:
Thomas K. Shires
Publikováno v:
Archives of Biochemistry and Biophysics. 171:695-707
Amino acid incorporation in vitro by rough microsomes is inhibited by concurrent lipoperoxidation of the membranes. Disjunction of polysomes from their binding sites was not demonstrable. During the lipoperoxidative inhibition, membrane alteration wa
Autor:
P.A. Krieter, Thomas K. Shires
Publikováno v:
Biochemical and Biophysical Research Communications. 94:606-611
Using a reticulocyte lysate system, total rat liver poly A+ RNA was translated in vitro and the apocytochrome b5 product examined by immunochemical methods. Demonstrably specific antisera to cytochrome b5 was produced in sheep against whole purified
Autor:
Henry C. Pitot, Thomas K. Shires
Publikováno v:
Advances in Enzyme Regulation. 11:255-272
Experiments with artificial polysome-membrane complexes are reported which indicate a functional competence in vitro similar to that of natural complexes derived from the rough endoplasmic reticulum. These experiments, involving transmembrane dischar