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of 15
pro vyhledávání: '"Thomas K. Ni"'
Autor:
Jessica S. Elman, Thomas K. Ni, Kristen E. Mengwasser, Dexter Jin, Ania Wronski, Stephen J. Elledge, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Summary: Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Externí odkaz:
https://doaj.org/article/e617fd7258c847d486aa6bcbaa90f6f9
Autor:
Wenhui Zhou, Thomas K. Ni, Ania Wronski, Benjamin Glass, Adam Skibinski, Andrew Beck, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1302-1317 (2016)
Summary: Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC). Despite its importance, this transcription factor is rarely mutated in BLBC, an
Externí odkaz:
https://doaj.org/article/36f427dd51724d3ab6355886b0cb3d35
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Nature
Nature
In cancer, tumor suppressor genes (TSGs) are frequently truncated, causing their encoded products to be non-functional or dominant-negative. We previously showed that premature polyadenylation (pPA) of MAGI3 truncates the gene, switching its function
Publikováno v:
Scientific Reports
In cancer, tumor suppressor genes (TSGs) are frequently truncated, causing their encoded products to be non-functional or dominant-negative. We previously showed that premature polyadenylation (pPA) of MAGI3 truncates the gene, switching its function
Autor:
Stephen J. Elledge, Charlotte Kuperwasser, Ania Wronski, Dexter X. Jin, Jessica S Elman, Kristen E. Mengwasser, Thomas K. Ni
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
SUMMARY Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Autor:
Charlotte Kuperwasser, Thomas K. Ni
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
Genetic mutation, chromosomal rearrangement and copy number amplification are common mechanisms responsible for generating gain-of-function, cancer-causing alterations. Here we report a new mechanism by which premature cleavage and polyadenylation (p
Autor:
Charlotte Kuperwasser, Thomas K. Ni
Publikováno v:
Cancer Research. 77:4995-4995
Cleavage and polyadenylation is a fundamental process in the control of gene expression, yet how cancer cells deregulate this process to generate cancer-causing alterations is only beginning to be appreciated. We previously showed that in human breas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(38)
Despite considerable efforts to sequence hypermutated cancers such as melanoma, distinguishing cancer-driving genes from thousands of recurrently mutated genes remains a significant challenge. To circumvent the problematic background mutation rates a
Autor:
Charlotte Kuperwasser, Thomas K. Ni
Publikováno v:
Molecular Cancer Research. 14:A48-A48
There is increasing appreciation that alterations to epigenetic mechanisms contribute directly to breast cancer development. In cancer cells, one such mechanism, called alternative polyadenylation (APA), has been observed to cause a general shortenin