Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas K. Ni"'
Autor:
Jessica S. Elman, Thomas K. Ni, Kristen E. Mengwasser, Dexter Jin, Ania Wronski, Stephen J. Elledge, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Summary: Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Externí odkaz:
https://doaj.org/article/e617fd7258c847d486aa6bcbaa90f6f9
Autor:
Wenhui Zhou, Thomas K. Ni, Ania Wronski, Benjamin Glass, Adam Skibinski, Andrew Beck, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1302-1317 (2016)
Summary: Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC). Despite its importance, this transcription factor is rarely mutated in BLBC, an
Externí odkaz:
https://doaj.org/article/36f427dd51724d3ab6355886b0cb3d35
Autor:
Thomas K Ni, Charlotte Kuperwasser
Publikováno v:
eLife, Vol 5 (2016)
Genetic mutation, chromosomal rearrangement and copy number amplification are common mechanisms responsible for generating gain-of-function, cancer-causing alterations. Here we report a new mechanism by which premature cleavage and polyadenylation (p
Externí odkaz:
https://doaj.org/article/42651322bee843f1ae186e80d641f206
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Nature
Nature
In cancer, tumor suppressor genes (TSGs) are frequently truncated, causing their encoded products to be non-functional or dominant-negative. We previously showed that premature polyadenylation (pPA) of MAGI3 truncates the gene, switching its function
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26650 (2011)
Somatic forward genetic screens have the power to interrogate thousands of genes in a single animal. Retroviral and transposon mutagenesis systems in mice have been designed and deployed in somatic tissues for surveying hematopoietic and solid tumor
Externí odkaz:
https://doaj.org/article/0f70b4a0295045bd967e044c41121660
Publikováno v:
Scientific Reports
In cancer, tumor suppressor genes (TSGs) are frequently truncated, causing their encoded products to be non-functional or dominant-negative. We previously showed that premature polyadenylation (pPA) of MAGI3 truncates the gene, switching its function
Autor:
Stephen J. Elledge, Charlotte Kuperwasser, Ania Wronski, Dexter X. Jin, Jessica S Elman, Kristen E. Mengwasser, Thomas K. Ni
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
SUMMARY Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Autor:
Charlotte Kuperwasser, Thomas K. Ni
Publikováno v:
Cancer Research. 77:4995-4995
Cleavage and polyadenylation is a fundamental process in the control of gene expression, yet how cancer cells deregulate this process to generate cancer-causing alterations is only beginning to be appreciated. We previously showed that in human breas
Autor:
Charlotte Kuperwasser, Thomas K. Ni
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
Genetic mutation, chromosomal rearrangement and copy number amplification are common mechanisms responsible for generating gain-of-function, cancer-causing alterations. Here we report a new mechanism by which premature cleavage and polyadenylation (p