Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Thomas K. Dawson"'
Autor:
Thomas K. Dawson, S.G. Krimmer, Maria-Elena Liosi, Kara J. Cutrona, Ana S. Newton, David E. Puleo, Joseph Schlessinger, Yoshihisa Suzuki, William L. Jorgensen
Publikováno v:
J Med Chem
Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential components of the JAK-STAT signaling pathway. Associated aberrant signaling is responsible for many forms of cancer and disorders of the immune system. The present focus is on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4147c54acb04879d3ac21b985bb19a75
https://europepmc.org/articles/PMC7949251/
https://europepmc.org/articles/PMC7949251/
Autor:
Saidu I, Ngulde, Umar K, Sandabe, Roger, Abounader, Thomas K, Dawson, Ying, Zhang, Ibrahim, Iliya, Isa M, Hussaini
Publikováno v:
BioMed Research International
Incidence of cancer is estimated to be on the increase and current anticancer drugs are characterized by narrow margin of safety and side effects. There is the need to explore new drugs especially from plants since plants serve as major source of dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef6d81e44d3b7ec6e7fb7a8e5c3e4ada
https://pubmed.ncbi.nlm.nih.gov/30931334
https://pubmed.ncbi.nlm.nih.gov/30931334
Autor:
Thomas K. Dawson, José A. Cisneros, S.G. Krimmer, Julian Tirado-Rives, Pawel Dziedzic, Michael J. Robertson, Ana S. Newton, William L. Jorgensen
Publikováno v:
ACS medicinal chemistry letters. 8(12)
Coordination of the ammonium group of Lys32 in the active site of human macrophage migration inhibitory factor (MIF) using a 1,7-naphthyridin-8-one instead of a quinoline is investigated. Both gas- and aqueous-phase DFT calculations for model systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d35db74ad416bfac382b7918178f34
https://pubmed.ncbi.nlm.nih.gov/29259749
https://pubmed.ncbi.nlm.nih.gov/29259749
Autor:
Andrew J. Kennedy, Joseph D. Houck, Thomas K. Dawson, Saundra D. Field, Niels D. Naimon, Kevin R. Lynch, Yugesh Kharel, Timothy L. Macdonald
Sphingosine 1-phosphate (S1P) is a potent growth-signaling lipid that has been implicated in cancer progression, inflammation, sickle cell disease, and fibrosis. Two sphingosine kinases (SphK1 and 2) are the source of S1P; thus, inhibitors of the Sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bfa952692ac007c2c1577103f44437
https://europepmc.org/articles/PMC4867490/
https://europepmc.org/articles/PMC4867490/