Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Thomas K van der Made"'
Autor:
Marit Keuper-Navis, Markus Walles, Birk Poller, Adam Myszczyszyn, Thomas K. van der Made, Joanne Donkers, Hossein Eslami Amirabadi, Martijn J. Wilmer, Saskia Aan, Bart Spee, Rosalinde Masereeuw, Evita van de Steeg
Publikováno v:
Pharmacological Research, Vol 195, Iss , Pp 106853- (2023)
Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrin
Externí odkaz:
https://doaj.org/article/06d95e9d904945618f9e6018cbd79e94
Autor:
Thomas K van der Made, Jan Snoeys, Lieve Dillen, Ils Pijpers, Daniel Scotcher, Aleksandra Galetin, Sophie Jonkers, Mario Monshouwer, Amin Rostami-Hodjegan, Frank Jacobs, Annett Kunze, Kathleen Steemans, An Tuytelaars, Marie-Emilie Willemin
Publikováno v:
Willemin, M, Van Der Made, T K, Pijpers, I, Dillen, L, Kunze, A, Jonkers, S, Steemans, K, Tuytelaars, A, Jacobs, F, Monshouwer, M, Scotcher, D, Rostami-hodjegan, A, Galetin, A & Snoeys, J 2021, ' Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions ', Clinical Pharmacokinetics . https://doi.org/10.1007/s40262-021-01004-2
BackgroundEndogenous biomarkers are promising tools to assess transporter-mediated drug–drug interactions early in humans.MethodsWe evaluated on a common and validated in vitro system the selectivity of 4-pyridoxic acid (PDA), homovanillic acid (HV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed80425cf49862269c9ed5238be7d0
https://doi.org/10.1007/s40262-021-01004-2
https://doi.org/10.1007/s40262-021-01004-2
Autor:
Marie-Emilie Willemin, Thomas K. Van Der Made, Ils Pijpers, Lieve Dillen, Annett Kunze, Sophie Jonkers, Kathleen Steemans, An Tuytelaars, Frank Jacobs, Mario Monshouwer, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin, Jan Snoeys
Publikováno v:
Clinical Pharmacokinetics. 61:463-463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f8419a092f97dfb0914cac8ad26f6c8
https://doi.org/10.1007/s40262-022-01109-2
https://doi.org/10.1007/s40262-022-01109-2
Autor:
Thomas K, van der Made, Michele, Fedecostante, Daniel, Scotcher, Amin, Rostami-Hodjegan, Javier, Sastre Toraño, Igor, Middel, Andries S, Koster, Karin G, Gerritsen, Vera, Jankowski, Joachim, Jankowski, Joost G J, Hoenderop, Rosalinde, Masereeuw, Aleksandra, Galetin
Publikováno v:
Molecular pharmaceutics. 16(11)
Indoxyl sulfate (IxS), a highly albumin-bound uremic solute, accumulates in chronic kidney disease (CKD) due to reduced renal clearance. This study was designed to specifically investigate the role of human serum albumin (HSA) in IxS renal secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e174667ba0e47bb91c69c3e67e09535
https://pubmed.ncbi.nlm.nih.gov/31525064
https://pubmed.ncbi.nlm.nih.gov/31525064