Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thomas K, Villiger"'
Autor:
Larissa Brosi, Thomas K. Villiger, Frank I. Bantleon, Anna Melone, Marie-Eve Überschlag, Daniele Dolce, Cedric Giegelmann, Michael Gerspach, Lorin Dirscherl, Sherin Panikulam, Patrick Romann, Anna Weston, Eric Kübler, Christian-B. Gerhold
Publikováno v:
CHIMIA, Vol 75, Iss 5 (2021)
Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity after infection or vaccinat
Externí odkaz:
https://doaj.org/article/69e7fe4015df4f13ac4f5683a212ce03
Autor:
Patrick Romann, Jakub Kolar, Daniela Tobler, Christoph Herwig, Jean‐Marc Bielser, Thomas K. Villiger
Publikováno v:
Biotechnology journalLITERATURE. 17(11)
Raman spectroscopy has gained popularity to monitor multiple process indicators simultaneously in biopharmaceutical processes. However, robust and specific model calibration remains a challenge due to insufficient analyte variability to train the mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2c4fcfb907ea1f818c8cefd72523bb
https://pubmed.ncbi.nlm.nih.gov/35900328
https://pubmed.ncbi.nlm.nih.gov/35900328
Autor:
Patrick Romann, Jakub Kolar, Loïc Chappuis, Christoph Herwig, Thomas K. Villiger, Jean-Marc Bielser
Publikováno v:
Biochemical Engineering Journal. 193:108873
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57be6008e6d2f35a29139d17a8a2e53
https://doi.org/10.1016/j.bej.2023.108873
https://doi.org/10.1016/j.bej.2023.108873
Autor:
Vania Bertrand, Sebastian Vogg, Massimo Morbidelli, Matthieu Stettler, Miroslav Soos, Hervé Broly, Thomas K. Villiger
Publikováno v:
Journal of Biotechnology. 279:27-36
The pharmaceutical production of recombinant proteins, such as monoclonal antibodies, is rather complex and requires proper development work. Accordingly, it is essential to develop appropriate scale-down models, which can mimic the corresponding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0afd54663364cfb2b7658f39825bdaf
https://doi.org/10.1016/j.jbiotec.2018.04.015
https://doi.org/10.1016/j.jbiotec.2018.04.015
Autor:
Massimo Morbidelli, Eric Lucas, Thomas K. Villiger, Matthieu Stettler, Benjamin Neunstoecklin, Daniel J. Karst, Hervé Broly, Miroslav Soos
Publikováno v:
Biochemical Engineering Journal. 131:84-94
Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is a delicate task, frequently leading to different conditions across scales. To provide a more rational reasoning behind scale-up of mammalian cell cultures, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25405db43f2fb5e93db5653e2f097df0
https://doi.org/10.1016/j.bej.2017.12.004
https://doi.org/10.1016/j.bej.2017.12.004
Autor:
Massimo Morbidelli, Ernesto Scibona, Markus Aebi, Chia-Wei Lin, Robert Gauss, Thomas K. Villiger, Marie-Estelle Losfeld
Publikováno v:
The FASEB Journal. 31:4623-4635
To study how the interaction between N-linked glycans and the surrounding amino acids influences oligosaccharide processing, we used protein disulfide isomerase (PDI), a glycoprotein bearing 5 N-glycosylation sites, as a model system and expressed it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252bf8e317c25b9d90138ff3febe2ca7
https://doi.org/10.1096/fj.201700403r
https://doi.org/10.1096/fj.201700403r
Publikováno v:
Macromolecules, 50 (14)
Because of their similarity with extracellular matrix, hydrogels are ideal substrates for cell growth. Hydrogels made of synthetic polymers are excellent alternatives to natural ones and offer the key advantage of precisely controllable degradation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af785a1b7e5d136219243f3b7d3ea038
https://doi.org/10.1021/acs.macromol.7b00902
https://doi.org/10.1021/acs.macromol.7b00902
Autor:
Matthieu Stettler, Thomas K. Villiger, Hervé Broly, Massimo Morbidelli, Jean-Marc Bielser, Miroslav Soos, Jonathan Souquet, Elisa Serra, Ernesto Scibona, Daniel J. Karst
Publikováno v:
Biotechnology and Bioengineering. 114:1978-1990
Mammalian cell perfusion cultures are gaining renewed interest as an alternative to traditional fed-batch processes for the production of therapeutic proteins, such as monoclonal antibodies (mAb). The steady state operation at high viable cell densit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::099288b5e500c099b2ea461a0d17ed3b
https://doi.org/10.1002/bit.26315
https://doi.org/10.1002/bit.26315
Autor:
Patrick Romann, Larissa Brosi, Marie-Eve Überschlag, Michael Gerspach, Christian B. Gerhold, Anna Melone, Frank I Bantleon, Anna Weston, Daniele Dolce, Sherin Panikulam, Cedric Giegelmann, Thomas K. Villiger, Eric Kübler, Lorin Dirscherl
Publikováno v:
CHIMIA. 75:446
Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity after infection or vaccinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab405463611ed0ca04115d9e7bdbd779
https://doi.org/10.2533/chimia.2021.446
https://doi.org/10.2533/chimia.2021.446
Autor:
Matthieu Stettler, Massimo Morbidelli, Miroslav Soos, Thomas K. Villiger, Hervé Broly, Ernesto Scibona
Publikováno v:
Biotechnology Progress. 32:1135-1148
N-linked glycosylation is known to be a crucial factor for the therapeutic efficacy and safety of monoclonal antibodies (mAbs) and many other glycoproteins. The nontemplate process of glycosylation is influenced by external factors which have to be t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10935523d231dadb41fd526ab66ed351
https://doi.org/10.1002/btpr.2315
https://doi.org/10.1002/btpr.2315