Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas K, Sin"'
Autor:
Guohua Zhang, Lindsey J. Anderson, Song Gao, Thomas K. Sin, Zicheng Zhang, Hongyu Wu, Syed H. Jafri, Solomon A. Graf, Peter C. Wu, Atreya Dash, Jose M. Garcia, Yi-Ping Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Unintentional weight loss, a first clinical sign of muscle wasting, is a major threat to cancer survival without a defined etiology. We previously identified in mice that p38β MAPK mediates cancer-induced muscle wasting by stimulating protein catabo
Externí odkaz:
https://doaj.org/article/498d1eecebc2415482d7a6d46b6067da
C/EBPβ is a key mediator of cancer-induced skeletal muscle wasting. However, the signaling mechanisms that activate C/EBPβ in the cancer milieu are poorly defined. Here, we report cancer-induced muscle wasting requires the transcriptional cofactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::246b228f24d82180849281ded435110c
https://doi.org/10.1158/0008-5472.c.6511263.v1
https://doi.org/10.1158/0008-5472.c.6511263.v1
Figure S1. Genotyping p300 mKO Figure S2. Lys39 mutation effect on Thr188 phosphorylation Figure S3. Lys39 acetylation is required for muscle mass loss Figure S4. Acetyltransferase activity of p300 is required for muscle mass loss Figure S5. p300 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc27f8a5843b601602195d26008f2f6
https://doi.org/10.1158/0008-5472.22422555
https://doi.org/10.1158/0008-5472.22422555
Autor:
Yi-Ping Li, Min Li, Jeffrey A. Frost, Yan Zuo, James Z. Zhu, Zicheng Zhang, Guohua Zhang, Thomas K. Sin
Cancer-associated cachexia, characterized by muscle wasting, is a lethal metabolic syndrome without defined etiology or established treatment. We previously found that p300 mediates cancer-induced muscle wasting by activating C/EBPβ, which then upre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6996feca6c600ea8ecafe661cb076a1f
https://doi.org/10.1158/0008-5472.c.6512085.v1
https://doi.org/10.1158/0008-5472.c.6512085.v1
Autor:
Yi-Ping Li, Min Li, Jeffrey A. Frost, Yan Zuo, James Z. Zhu, Zicheng Zhang, Guohua Zhang, Thomas K. Sin
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0243181545ef63dc23e77239557febfe
https://doi.org/10.1158/0008-5472.22425588.v1
https://doi.org/10.1158/0008-5472.22425588.v1
Publikováno v:
Cellular Physiology and Biochemistry, Vol 35, Iss 2, Pp 541-552 (2015)
Aging individuals and diabetic patients often exhibit concomitant reductions of skeletal muscle mass/strength and insulin sensitivity, suggesting an intimate link between muscle aging and insulin resistance. Foxo1, a member of the FOXO transcription
Externí odkaz:
https://doaj.org/article/f104d61e7389405aa4310fe45d61a2f8
Autor:
Felix N. Ugwu, Angus P. Yu, Thomas K. Sin, Bjorn T. Tam, Christopher W. Lai, S. C. Wong, Parco M. Siu
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Unacylated ghrelin, the predominant form of circulating ghrelin, protects myotubes from cell death, which is a known attribute of pressure ulcers. In this study, we investigated whether unacylated ghrelin protects skeletal muscle from pressure-induce
Externí odkaz:
https://doaj.org/article/fc1bae9287a849f291bb90d9c1529a3a
Autor:
Guohua Zhang, James Z. Zhu, Min Li, Yan Zuo, Jeffrey A. Frost, Zicheng Zhang, Yi-Ping Li, Thomas K. Sin
Publikováno v:
Cancer Res
Cancer-associated cachexia, characterized by muscle wasting, is a lethal metabolic syndrome without defined etiology or established treatment. We previously found that p300 mediates cancer-induced muscle wasting by activating C/EBPβ, which then upre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b402c8423604db17dc2c3ce082faf0b3
https://doi.org/10.1158/0008-5472.can-19-3219
https://doi.org/10.1158/0008-5472.can-19-3219
Publikováno v:
Cancer Research. 79:1331-1342
C/EBPβ is a key mediator of cancer-induced skeletal muscle wasting. However, the signaling mechanisms that activate C/EBPβ in the cancer milieu are poorly defined. Here, we report cancer-induced muscle wasting requires the transcriptional cofactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf68e13089c175fe6c65abe6ba6ce5e
https://doi.org/10.1158/0008-5472.can-18-1653
https://doi.org/10.1158/0008-5472.can-18-1653
Publikováno v:
Biochemical and biophysical research communications. 529(2)
Objective The objective of this study was to investigate the role of p38-C/EBPβ signaling in leiomyoma cells and myometrial cells challenged with Activin A, and to identify specifically the isoform of p38 MAPK that mediates the effects of Activin A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6891b72d394d2bd38b734fa5addf161
https://pubmed.ncbi.nlm.nih.gov/32703439
https://pubmed.ncbi.nlm.nih.gov/32703439