Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas K, Chang"'
Autor:
Stephen K. Doberstein, Seema S. Kantak, Theresa D. Sweeney, Jicai Huang, Yujun Wang, Chunmei Ji, Yolanda M. Kirksey, Rupesh S. Kanhere, Rhoneil L. Pena, Marina Konakova, Thomas K. Chang, Cherie F. Ali, Laurie A. VanderVeen, Paul W. Sims, Xiaofeng Liu, Dawei Sheng, Peter B. Kirk, Murali K. Addepalli, Steve R. Lee, John L. Langowski, Ute Hoch, Deborah H. Charych
Binding curves from surface plasmon resonance studies of purified active 1-PEG-IL-2 released from NKTR-214 binding to IL-2Rαβ and IL-2Rβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134c32d3a79528e455bdc621b359c574
https://doi.org/10.1158/1078-0432.22460627.v1
https://doi.org/10.1158/1078-0432.22460627.v1
Autor:
Stephen K. Doberstein, Seema S. Kantak, Theresa D. Sweeney, Jicai Huang, Yujun Wang, Chunmei Ji, Yolanda M. Kirksey, Rupesh S. Kanhere, Rhoneil L. Pena, Marina Konakova, Thomas K. Chang, Cherie F. Ali, Laurie A. VanderVeen, Paul W. Sims, Xiaofeng Liu, Dawei Sheng, Peter B. Kirk, Murali K. Addepalli, Steve R. Lee, John L. Langowski, Ute Hoch, Deborah H. Charych
NKTR-214 produces potent immune activation in cynomolgus monkeys and is well tolerated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773275042310911a52bb03541dd28bdf
https://doi.org/10.1158/1078-0432.22460621
https://doi.org/10.1158/1078-0432.22460621
Autor:
Stephen K. Doberstein, Seema S. Kantak, Theresa D. Sweeney, Jicai Huang, Yujun Wang, Chunmei Ji, Yolanda M. Kirksey, Rupesh S. Kanhere, Rhoneil L. Pena, Marina Konakova, Thomas K. Chang, Cherie F. Ali, Laurie A. VanderVeen, Paul W. Sims, Xiaofeng Liu, Dawei Sheng, Peter B. Kirk, Murali K. Addepalli, Steve R. Lee, John L. Langowski, Ute Hoch, Deborah H. Charych
Antitumor immunity stimulated by NKTR-214 and anti-CTLA-4 in mouse EMT6 tumors requires innate and adaptive immune responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c197ba67e23e5f0b312c533d69aba
https://doi.org/10.1158/1078-0432.22460624
https://doi.org/10.1158/1078-0432.22460624
Autor:
Stephen K. Doberstein, Seema S. Kantak, Theresa D. Sweeney, Jicai Huang, Yujun Wang, Chunmei Ji, Yolanda M. Kirksey, Rupesh S. Kanhere, Rhoneil L. Pena, Marina Konakova, Thomas K. Chang, Cherie F. Ali, Laurie A. VanderVeen, Paul W. Sims, Xiaofeng Liu, Dawei Sheng, Peter B. Kirk, Murali K. Addepalli, Steve R. Lee, John L. Langowski, Ute Hoch, Deborah H. Charych
Purpose: Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately 10% of patients; however, severe side effects limit maximal dosing and thus the number of pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fe8117f5e79650581c47831ffd8438
https://doi.org/10.1158/1078-0432.c.6524552
https://doi.org/10.1158/1078-0432.c.6524552
Autor:
Stephen K. Doberstein, Seema S. Kantak, Theresa D. Sweeney, Jicai Huang, Yujun Wang, Chunmei Ji, Yolanda M. Kirksey, Rupesh S. Kanhere, Rhoneil L. Pena, Marina Konakova, Thomas K. Chang, Cherie F. Ali, Laurie A. VanderVeen, Paul W. Sims, Xiaofeng Liu, Dawei Sheng, Peter B. Kirk, Murali K. Addepalli, Steve R. Lee, John L. Langowski, Ute Hoch, Deborah H. Charych
In vitro hydrolysis of NKTR-214 under physiological conditions generating NKTR-214 released IL-2 conjugates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e92f0606d6312e0d592dd0c9cf5ea91
https://doi.org/10.1158/1078-0432.22460630
https://doi.org/10.1158/1078-0432.22460630
Autor:
Stephen K. Doberstein, Seema S. Kantak, Theresa D. Sweeney, Jicai Huang, Yujun Wang, Chunmei Ji, Yolanda M. Kirksey, Rupesh S. Kanhere, Rhoneil L. Pena, Marina Konakova, Thomas K. Chang, Cherie F. Ali, Laurie A. VanderVeen, Paul W. Sims, Xiaofeng Liu, Dawei Sheng, Peter B. Kirk, Murali K. Addepalli, Steve R. Lee, John L. Langowski, Ute Hoch, Deborah H. Charych
Supplemental Materials and Methods. ELISA study materials; NKTR-214 chemistry; Mapping of PEGylation sites; Identification of active released IL-2 conjugates; Binding affinity to IL-2 receptors; In vivo immune cell phenotyping, In vivo immune cell ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0355aa629ebbad4322a3a47b80293276
https://doi.org/10.1158/1078-0432.22460618
https://doi.org/10.1158/1078-0432.22460618
Autor:
Renée S. Martin, Paul H. Reynen, Joyce J. Calixto, Christian L. Reyes, Thomas K. Chang, Paul S. Dietrich, Douglas W. Bonhaus, Stephen J. MacLennan
Publikováno v:
Journal of Biomolecular Screening. 7:281-289
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872aa60a9e3b08fd2f60127950ca6446
https://doi.org/10.1089/108705702760047781
https://doi.org/10.1089/108705702760047781
Autor:
Gillian F. Knight, Geoffrey Burnstock, Rick Popert, Stephen B. McMahon, Barry A. O’Reilly, Janice Rymer, Anthony P.D.W. Ford, Thomas K. Chang, Alan Kosaka
Publikováno v:
Journal of Urology. 167:157-164
Purpose: It is clear from previous studies that adenosine triphosphate is released as a contractile co-transmitter with acetylcholine from parasympathetic nerves supplying the mammalian bladder but the physiological significance of ligand gated purin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59abf9530fe9ee110e4593821296799
https://doi.org/10.1016/s0022-5347(05)65403-1
https://doi.org/10.1016/s0022-5347(05)65403-1
Autor:
Thomas K. Chang, Alan Kosaka, Anthony P.D.W. Ford, Rick Popert, Janice Rymer, Stephen B. McMahon, Barry A. O’Reilly
Publikováno v:
The Journal of Urology. :1730-1734
Purpose: In adults there is evidence that adenosine triphosphate acting at P2X receptors functions as a co-transmitter at vesical smooth muscle. The contractile mechanisms of human fetal bladder have been studied to a limited extent and it remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049ea2a7419fd8e5f3d19187333e5898
https://doi.org/10.1097/00005392-200105000-00090
https://doi.org/10.1097/00005392-200105000-00090
Publikováno v:
Proceedings of the National Academy of Sciences. 91:12544-12548
A variant of subtilisin BPN', which we call subtiligase, has been used to ligate esterified peptides site-specifically onto the N termini of proteins or peptides in aqueous solution and in high yield. We have produced biotinylated or heavy-atom deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76ee521dcb9d5cd313e4b75868fcfc8
https://doi.org/10.1073/pnas.91.26.12544
https://doi.org/10.1073/pnas.91.26.12544