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of 13
pro vyhledávání: '"Thomas Jursa"'
Determinants of Hair Manganese, Lead, Cadmium and Arsenic Levels in Environmentally Exposed Children
Publikováno v:
Toxics, Vol 6, Iss 2, p 19 (2018)
Biomarkers of environmental metal exposure in children are important for elucidating exposure and health risk. While exposure biomarkers for As, Cd, and Pb are relatively well defined, there are not yet well-validated biomarkers of Mn exposure. Here,
Externí odkaz:
https://doaj.org/article/2cdd459f97664a21b28f34c2d29148e4
Autor:
Cherish A Taylor, Stephanie M Grant, Thomas Jursa, Ashvini Melkote, Rebecca Fulthorpe, Michael Aschner, Donald R Smith, Rueben A Gonzales, Somshuvra Mukhopadhyay
Publikováno v:
Metallomics. 15
Loss-of-function mutations in SLC30A10 induce hereditary manganese (Mn)-induced neuromotor disease in humans. We previously identified SLC30A10 to be a critical Mn efflux transporter that controls physiological brain Mn levels by mediating hepatic an
Autor:
Cherish A. Taylor, Stephanie Grant, Thomas Jursa, Michael Aschner, Donald R. Smith, Reuben Gonzales, Somshuvra Mukhopadhyay
Metals such as copper, iron, and manganese (Mn) are essential for life, but induce neurotoxicity at elevated levels. Yet, the neuronal mechanisms of metal-induced neurological disease are largely unclear. A primary limitation has been an inability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0a84d33c486eed8621802d8cc0fcd6
https://doi.org/10.1101/2022.02.21.481385
https://doi.org/10.1101/2022.02.21.481385
Publikováno v:
Proc Natl Acad Sci U S A
Manganese (Mn) is an essential metal that induces incurable parkinsonism at elevated levels. However, unlike other essential metals, mechanisms that regulate mammalian Mn homeostasis are poorly understood, which has limited therapeutic development. H
Autor:
Scott Fendorf, Juan S. Lezama Pacheco, Thomas Jursa, Roberto Lucchini, Cardius Richardson, Robert O. Ritchie, Travis E. Conley, Donald R. Smith, Neil K. N. Dave, Stefano Guazzetti
Publikováno v:
Environmental research. 204
Studies have established associations between environmental and occupational manganese (Mn) exposure and executive and motor function deficits in children, adolescents, and adults. These health risks from elevated Mn exposure underscore the need for
Autor:
Donald R. Smith, Thomas Jursa, Somshuvra Mukhopadhyay, William Shawlot, Michael Aschner, Chunyi Liu, Cherish A. Taylor, Steven Hutchens
Publikováno v:
Journal of Biological Chemistry. 294:1860-1876
The essential metal manganese becomes neurotoxic at elevated levels. Yet, the mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of-function mutations in SLC30A10, a cell surface–localized manganese efflux transporter in
Autor:
Somshuvra Mukhopadhyay, Michael Aschner, Weiling Yin, Thomas Jursa, William Shawlot, Chunyi Liu, Donald R. Smith, Beth K. Chaffee, Steven Hutchens, Andrea C. Gore
Publikováno v:
Journal of Biological Chemistry. 292:9760-9773
Manganese is an essential metal that becomes toxic at elevated levels. Loss-of-function mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a heritable manganese metabolism disorder resulting in elevated manganese leve
Autor:
Theresa M. Bastain, Thomas Chavez, Tahlia L. Hodes, Thomas Jursa, Erika Garcia, Ramsunder Iyer, William E. Funk, Brendan H. Grubbs, Donald R. Smith, Caitlin G. Howe, Kiros Berhane, Carrie V. Breton, Shohreh F. Farzan
Publikováno v:
Environ Res
Prenatal arsenic exposure has been associated with reduced fetal growth and increased risk for preterm birth, but most studies have been conducted in highly exposed populations outside the U.S. or in non-Hispanic populations in the rural U.S. The obj
Determinants of Hair Manganese, Lead, Cadmium and Arsenic Levels in Environmentally Exposed Children
Publikováno v:
Toxics, vol 6, iss 2
Toxics
Toxics, Vol 6, Iss 2, p 19 (2018)
Toxics; Volume 6; Issue 2; Pages: 19
Toxics
Toxics, Vol 6, Iss 2, p 19 (2018)
Toxics; Volume 6; Issue 2; Pages: 19
Biomarkers of environmental metal exposure in children are important for elucidating exposure and health risk. While exposure biomarkers for As, Cd, and Pb are relatively well defined, there are not yet well-validated biomarkers of Mn exposure. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859a6ae16c75d421dd4ce02fed0c0c5b
https://escholarship.org/uc/item/4717n4xn
https://escholarship.org/uc/item/4717n4xn
Autor:
Beth K. Dray, Roman S. Polishchuk, Somshuvra Mukhopadhyay, Andrea C. Gore, Elena V. Polishchuk, Michael Aschner, Steven Hutchens, Chunyi Liu, Donald R. Smith, Thomas Jursa, William Shawlot
SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary manganese toxicity. Patients have elevated manganese in the blood and brain and develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713f12ed8b8aaafb433e41e7d24fd7da
https://europepmc.org/articles/PMC5633123/
https://europepmc.org/articles/PMC5633123/