Výsledky vyhledávání - "Thomas J. Zamborelli"

A comparison of folding techniques in the chemical synthesis of the epidermal growth factor-like domain in neu differentiation factor α/β

Autor: Jones T, Brian D. Bennett, Yunjen Young, Jingwen Zhang, Mitsuru Haniu, Thomas J. Zamborelli, Mark A. Jarosinski, Dodson Ws, Douglas M. Lenz, Bennet J. Harding, Chuan-Fa Liu

Publikováno v: The Journal of Peptide Research. 55:359-371

The 52-residue alpha/beta chimera of the epidermal growth factor-like domain in neu differentiation factor (NDFealpha/beta) has been synthesized and folded to form a three disulfide bridge (Cys182-Cys196, Cys190-Cys210, Cys212-Cys221) containing pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28ed17cf8a4005a9b68ffd21a6b1e1a6
https://doi.org/10.1034/j.1399-3011.2000.00672.x

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A Neu Differentiation Factor (NDF) Domain Essential for Proliferation and Alterations in Morphology of Colonic Epithelial CellsIn Vitro

Autor: Naili Liu, David L. Lacey, Susan K. Pekar, Barry J. Ratzkin, John Whoriskey, Gary Elliott, John P. Mayer, John E. Tarpley, Thomas J. Zamborelli, Steven Kiyoshi Yoshinaga, Shinichi Hara, D. M. Lenz

Publikováno v: Growth Factors. 15:307-321

The Neu Differentiation Factors (NDFs, also termed "heregulins") are a family of proteins that were first isolated as ligands for the HER2 (ergB2, or p185neu) receptor protein tyrosine kinase. Here we show that NDF acts to stimulate the proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f924bfef892b7ce2d581d7e2696e0ff
https://doi.org/10.3109/08977199809017485

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Interaction of rabbit muscle aldolase at high ionic strengths with vanadate and other oxoanions

Autor: Katakam Sudhakar, Thomas J. Zamborelli, Debbie C. Crans

Publikováno v: Biochemistry. 31:6812-6821

Reductive, nonreductive, and photolytic interactions of vanadate with fructose-1,6-bisphosphate aldolase were examined and used to explore the interactions of oxoanions with aldolase. Aldolase is known to interact strongly with oxoanions at low ionic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1e13d3c79029bd7f9b18b0c5fe4280
https://doi.org/10.1021/bi00144a023

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SAR of the novel neuropeptides orexin-A and B

Autor: W. Scott Dodson, Bennet J. Harding, Mark A. Jarosinski, Douglas M. Lenz, Hai Yan, E. William Karbon, Thomas J. Zamborelli, James W. Baumgartner, Keegan Cooke

Publikováno v: Peptides for the New Millennium ISBN: 0792364457

Detailed functional evaluation and structure analysis of these Ox-A and Ox-B analogs are currently underway. Future analog design aims to identify peptides with greater selectivity ratios at the Ox-1R and Ox-2R receptors. We are also interested in id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2feef11c54412086d31016d4d5bcbbae
https://doi.org/10.1007/0-306-46881-6_266

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Chemical synthesis and characterization of the hypothalamic form of CART: CART(69–116), a new anorectic neuropeptide

Autor: Mitsuru Haniu, Thomas J. Zamborelli, Douglas M. Lenz, Mark A. Jarosinski, Yunjen Young, Bennet J. Harding, W. Scott Dodson

Publikováno v: Peptides for the New Millennium ISBN: 0792364457

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33f986f3d7cfbf85c63d844d18523a05
https://doi.org/10.1007/0-306-46881-6_55

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Structure activity relationships of NDF isoforms

Autor: Barry J. Ratzkin, David L. Lacey, John Whoriskey, Thomas J. Zamborelli, Susan K. Pekar, John E. Tarpley, G. S. Elliot, J. P. Mayera, Steven Kiyoshi Yoshinaga, D. M. Lenz, N. Lu, Shinichi Hara

Publikováno v: American Peptide Symposia ISBN: 0792351606

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f902d25b764da8b2fef7a856857430b
https://doi.org/10.1007/0-306-46862-x_276

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Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G

Autor: Knut Adermann, Christina A Jacobson, Tomoyuki Shishido, Thomas J. Zamborelli, Hidesaburo Hanafusa, Sarah K. Burrell, Kerstin B Müller, David Cowburn, Genhong Cheng, Christian Kardinal, Baolin Wang, Jie Zheng, Jan Voss, Stephan M. Feller, Guido Posern, Beatrice S. Knudsen, Gary D. Kruh, Douglas M. Lenz

Publikováno v: Oncogene. 16(15)

Many Src Homology 3 (SH3) domains function as molecular adhesives in intracellular signal transduction. Based on previous ultrastructural studies, short motifs which bind to the first SH3 domains of the adapters Crk and CRKL were selectively mutageni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900ba1a086023c7e8fb4d884cdfeee81
https://pubmed.ncbi.nlm.nih.gov/9591773

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Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice

Autor: Douglas M. Lenz, Nikolaus Neu, Gerhard Grässl, Felix Offner, Sarah K. Burrell, Thomas J. Zamborelli, Josef M. Penninger, Kurt Bachmaier, Kerstin Luze, Christian Pummerer

Publikováno v: The Journal of clinical investigation. 97(9)

Immunization with cardiac myosin induces T cell-mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart disease. This study was undertaken to identify pathogenic epitopes on the myosin molecule. Our approach wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614bc5832c3e91f3771172a4150be4db
https://pubmed.ncbi.nlm.nih.gov/8621795

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