Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Thomas J. Wubben"'
Autor:
Shubha Subramanya, Moloy T. Goswami, Nicholas Miller, Eric Weh, Sraboni Chaudhury, Li Zhang, Anthony Andren, Heather Hager, Katherine M. Weh, Costas A. Lyssiotis, Cagri G. Besirli, Thomas J. Wubben
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an underlying factor contributing to photoreceptor loss. Therefore, a comprehensive understandin
Externí odkaz:
https://doaj.org/article/45ce965be4f045d3b05edbc90670c130
Autor:
Varun Kamat, Matthew K. Grumbine, Khang Bao, Kedar Mokate, Gamal Khalil, Daniel Cook, Brandon Clearwater, Richard Hirst, Jarrod Harman, Myriam Boeck, Zhongjie Fu, Lois E.H. Smith, Moloy Goswami, Thomas J. Wubben, Emily M. Walker, Jie Zhu, Scott A. Soleimanpour, Jarrad M. Scarlett, Brian M. Robbings, Daniel Hass, James B. Hurley, Ian R. Sweet
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100642- (2023)
Summary: To address the needs of the life sciences community and the pharmaceutical industry in pre-clinical drug development to both maintain and continuously assess tissue metabolism and function with simple and rapid systems, we improved on the in
Externí odkaz:
https://doaj.org/article/3224701920bf49ea8c3bff2c8370db61
Autor:
Eric Weh, Moloy Goswami, Sraboni Chaudhury, Roshini Fernando, Nick Miller, Heather Hager, Sarah Sheskey, Vikram Sharma, Thomas J. Wubben, Cagri G. Besirli
Publikováno v:
Cells, Vol 12, Iss 16, p 2043 (2023)
HK2 and PKM2 are two main regulators of aerobic glycolysis. Photoreceptors (PRs) use aerobic glycolysis to produce the biomass necessary for the daily renewal of their outer segments. Previous work has shown that HK2 and PKM2 are important for the no
Externí odkaz:
https://doaj.org/article/a4644ac0853245d198e63eafc1567163
Autor:
Thomas J. Wubben, Sraboni Chaudhury, Brennan T. Watch, Jeanne A. Stuckey, Eric Weh, Roshini Fernando, Moloy Goswami, Mercy Pawar, Jason C. Rech, Cagri G. Besirli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 705 (2023)
Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy. However, th
Externí odkaz:
https://doaj.org/article/7124d30a36fa4bc784f3b67ee9fb35b2
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Photoreceptor death is central to vision loss in various retinal diseases. Disruption of nutrient availability and cell metabolism may underlie photoreceptor death. In this review, Pan et al. focus on the recent advances in the understanding of photo
Externí odkaz:
https://doaj.org/article/ca9951a910fd4efaa18cc5cdbd6df2ac
Publikováno v:
American Journal of Ophthalmology. 243:77-82
To highlight the financial incentive to the physician of choosing an intravitreal anti-vascular endothelial growth factor (VEGF)-based strategy for treating non-proliferative and proliferative diabetic retinopathy, and its possible risks to the patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e538441f4b921a8123a087a2b455d38e
https://doi.org/10.1016/j.ajo.2022.07.014
https://doi.org/10.1016/j.ajo.2022.07.014
Publikováno v:
American Journal of Ophthalmology. 250:188-189
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067995b5beb864010edb46e4c4546272
https://doi.org/10.1016/j.ajo.2023.02.015
https://doi.org/10.1016/j.ajo.2023.02.015
Publikováno v:
American Journal of Ophthalmology. 250:192-193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3039618d94b17c15ffc3bb5dd35200
https://doi.org/10.1016/j.ajo.2023.01.009
https://doi.org/10.1016/j.ajo.2023.01.009
Autor:
Nicholas M. Carducci, Thomas J Wubben, Katie X Li, Omar Moinuddin, Cagri G. Besirli, David N. Zacks
Publikováno v:
Ophthalmic Surgery, Lasers and Imaging Retina. 52:593-600
BACKGROUND AND OBJECTIVE: To investigate the effect of the coronavirus disease 2019 (COVID-19) lockdown on the presentation and management of acute, primary rhegmatogenous retinal detachment (RRD). PATIENTS AND METHODS: This was a single-center, cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5392dafb3079f838c099e1def33bbb
https://doi.org/10.3928/23258160-20211015-01
https://doi.org/10.3928/23258160-20211015-01
Publikováno v:
Ophthalmic surgery, lasersimaging retina. 53(11)
Perfluorocarbon liquid (PFCL) is an important adjunct in pars plana vitrectomy (PPV) for complex retinal detachment (RD). Complete removal of PFCL is critical to prevent retinal inflammation and cellular toxicity, but removal is not risk-free. We rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ce875125cacc7e9d2199f27082e723
https://pubmed.ncbi.nlm.nih.gov/36378617
https://pubmed.ncbi.nlm.nih.gov/36378617