Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Thomas J. Van Blarcom"'
Autor:
Spencer Park, Edward Pascua, Kevin C. Lindquist, Christopher Kimberlin, Xiaodi Deng, Yvonne S. L. Mak, Zea Melton, Theodore O. Johnson, Regina Lin, Bijan Boldajipour, Robert T. Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J. Van Blarcom, Javier Chaparro-Riggers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.
Externí odkaz:
https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec
Autor:
Javier Chaparro-Riggers, Barbra J. Sasu, Siler H. Panowski, Thomas J. Van Blarcom, Bijan Boldajipour, Yi Zhang, Zea Melton, Cecilia Lay, Janette Sutton, Spencer Park, Andrew R. Nager, Regina J. Lin
Supplementary Data from Design and Validation of Inducible TurboCARs with Tunable Induction and Combinatorial Cytokine Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1884a4084a106e78725cbd7dac8cc
https://doi.org/10.1158/2326-6066.22545443
https://doi.org/10.1158/2326-6066.22545443
Autor:
Javier Chaparro-Riggers, Barbra J. Sasu, Siler H. Panowski, Thomas J. Van Blarcom, Bijan Boldajipour, Yi Zhang, Zea Melton, Cecilia Lay, Janette Sutton, Spencer Park, Andrew R. Nager, Regina J. Lin
Although cytokine support can enhance CAR T-cell function, coadministering cytokines or engineering CAR T cells to secrete cytokines can result in toxicities. To mitigate these safety risks, we engineered iTurboCAR T cells that coexpress a novel indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d748d06d80b487e1308b2a261e5e9f
https://doi.org/10.1158/2326-6066.c.6550943.v1
https://doi.org/10.1158/2326-6066.c.6550943.v1
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Pavel Strop, Arvind Rajpal, David Shelton, Jeffrey L. Wolf, Thomas G. Martin, Bernard Buetow, Ingrid Pardo, Michael Mirsky, Bora Han, Bing Kuang, Allison G. Chunyk, Kevin C. Lindquist, Yik Andy Yeung, Thomas J. Van Blarcom, Sherman M. Chin, Russell G. Dushin, Marjorie Bateman, Santiago Farias, Kathy Delaria, Wei Chen, Edward Pascua, Cris Kamperschroer, Laura Aschenbrenner, Tao Geng, Amy Chen, Yi Zhang, Tracy C. Kuo, Siler H. Panowski
BCMA bispecific is highly active in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b3e6c190c08ac317b01e7ce3f2069
https://doi.org/10.1158/1535-7163.22510278
https://doi.org/10.1158/1535-7163.22510278
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Pavel Strop, Arvind Rajpal, David Shelton, Jeffrey L. Wolf, Thomas G. Martin, Bernard Buetow, Ingrid Pardo, Michael Mirsky, Bora Han, Bing Kuang, Allison G. Chunyk, Kevin C. Lindquist, Yik Andy Yeung, Thomas J. Van Blarcom, Sherman M. Chin, Russell G. Dushin, Marjorie Bateman, Santiago Farias, Kathy Delaria, Wei Chen, Edward Pascua, Cris Kamperschroer, Laura Aschenbrenner, Tao Geng, Amy Chen, Yi Zhang, Tracy C. Kuo, Siler H. Panowski
Tables show PK kinetics, plasma cell numbers, and patient data. Methods include all supplemental methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f21b0175c33170d2642c58ea1c4072b
https://doi.org/10.1158/1535-7163.22510263
https://doi.org/10.1158/1535-7163.22510263
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Pavel Strop, Arvind Rajpal, David Shelton, Jeffrey L. Wolf, Thomas G. Martin, Bernard Buetow, Ingrid Pardo, Michael Mirsky, Bora Han, Bing Kuang, Allison G. Chunyk, Kevin C. Lindquist, Yik Andy Yeung, Thomas J. Van Blarcom, Sherman M. Chin, Russell G. Dushin, Marjorie Bateman, Santiago Farias, Kathy Delaria, Wei Chen, Edward Pascua, Cris Kamperschroer, Laura Aschenbrenner, Tao Geng, Amy Chen, Yi Zhang, Tracy C. Kuo, Siler H. Panowski
The restricted expression pattern of B-cell maturation antigen (BCMA) makes it an ideal tumor-associated antigen (TAA) for the treatment of myeloma. BCMA has been targeted by both CD3 bispecific antibody and antibody–drug conjugate (ADC) modalities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e53d5a22469996870b78467034a668
https://doi.org/10.1158/1535-7163.c.6539562.v1
https://doi.org/10.1158/1535-7163.c.6539562.v1
Autor:
Yasmina Noubia Abdiche, Adam Miles, Josh Eckman, Davide Foletti, Thomas J Van Blarcom, Yik Andy Yeung, Jaume Pons, Arvind Rajpal
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92451 (2014)
Here, we demonstrate how array-based label-free biosensors can be applied to the multiplexed interaction analysis of large panels of analyte/ligand pairs, such as the epitope binning of monoclonal antibodies (mAbs). In this application, the larger th
Externí odkaz:
https://doaj.org/article/e1995642182a41caada3267f6a733df6
Autor:
Regina J. Lin, Andrew R. Nager, Spencer Park, Janette Sutton, Cecilia Lay, Zea Melton, Yi Zhang, Bijan Boldajipour, Thomas J. Van Blarcom, Siler H. Panowski, Barbra J. Sasu, Javier Chaparro-Riggers
Publikováno v:
Cancer immunology research. 10(9)
Although cytokine support can enhance CAR T-cell function, coadministering cytokines or engineering CAR T cells to secrete cytokines can result in toxicities. To mitigate these safety risks, we engineered iTurboCAR T cells that coexpress a novel indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf1be13b34c656312edf883bd5b1f08
https://pubmed.ncbi.nlm.nih.gov/35881865
https://pubmed.ncbi.nlm.nih.gov/35881865