Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thomas J. Tull"'
Autor:
Lucia Montorsi, Michael J. Pitcher, Yuan Zhao, Chiara Dionisi, Alicia Demonti, Thomas J. Tull, Pawan Dhami, Richard J. Ellis, Cynthia Bishop, Jeremy D. Sanderson, Sahil Jain, David D’Cruz, Deena L. Gibbons, Thomas H. Winkler, Mats Bemark, Francesca D. Ciccarelli, Jo Spencer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Intestinal homeostasis is maintained by the response of gut-associated lymphoid tissue to bacteria transported across the follicle associated epithelium into the subepithelial dome. The initial response to antigens and how bacteria are handl
Externí odkaz:
https://doaj.org/article/335f7b7096184522be8b2a65d72908f9
Autor:
Yuan Zhao, Mohamed Uduman, Jacqueline H. Y. Siu, Thomas J. Tull, Jeremy D. Sanderson, Yu-Chang Bryan Wu, Julian Q. Zhou, Nedyalko Petrov, Richard Ellis, Katrina Todd, Konstantia-Maria Chavele, William Guesdon, Anna Vossenkamper, Wayel Jassem, David P. D’Cruz, David J. Fear, Susan John, Dagmar Scheel-Toellner, Claire Hopkins, Estefania Moreno, Natalie L. Woodman, Francesca Ciccarelli, Susanne Heck, Steven H. Kleinstein, Mats Bemark, Jo Spencer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despi
Externí odkaz:
https://doaj.org/article/18e17622ab574decbfaad7cce6011bef
Autor:
Chathyan Pararasa, Na Zhang, Thomas J. Tull, Ming H. A. Chong, Jacqueline H. Y. Siu, William Guesdon, Konstantia Maria Chavele, Jeremy D. Sanderson, Louise Langmead, Klaartje Kok, Jo Spencer, Anna Vossenkamper
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The intestinal mucosa in inflammatory bowel disease (IBD) contains increased frequencies of lymphocytes and a disproportionate increase in plasma cells secreting immunoglobulin (Ig)G relative to other isotypes compared to healthy controls. Despite co
Externí odkaz:
https://doaj.org/article/7ee34ccfbf214c5fa8a65952a8f16b71
Autor:
Rebekah L Velounias, Thomas J Tull
Publikováno v:
Clinical and Experimental Immunology. 210:201-216
SummaryOur understanding of the B-cell subsets found in human blood and their functional significance has advanced greatly in the past decade. This has been aided by the evolution of high dimensional phenotypic tools such as mass cytometry and single
Publikováno v:
Immunology Letters. :66-67
Publikováno v:
Clinical and Experimental Immunology. 210:199-200
The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in diff
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood
Autor:
Jacqueline H.Y. Siu, Michael J. Pitcher, Thomas J. Tull, Rebekah L. Velounias, William Guesdon, Lucia Montorsi, Krishnaa T. Mahbubani, Richard Ellis, Pawan Dhami, Katrina Todd, Ulrich D. Kadolsky, Michelle Kleeman, David P. D’Cruz, Kourosh Saeb-Parsy, Mats Bemark, Gavin J. Pettigrew, Jo Spencer
Publikováno v:
Spencer, J, Siu, J, Pitcher, M, Tull, T, Velounias, R, Guesdon, W, Montorsi, L, Mahbubani, K, Ellis, R, kadolsky, U, Kleeman, M, D'Cruz, D, Saeb-Parsy, K, Bemark, M & Pettigrew, G 2022, ' Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood ', Science Immunology, vol. 7, no. 69, pp. eabm9060 . https://doi.org/10.1126/sciimmunol.abm9060
B cells generate antibodies that are essential for immune protection, but their subgroups are poorly defined. Here, we perform undirected deep profiling of B cells in matched human lymphoid tissues from deceased transplant organ donors and blood. In
Autor:
Thomas J Tull, Emma Benton
Publikováno v:
Clin Med (Lond)
Immunobullous diseases are blistering cutaneous disorders that are caused by pathogenic antibodies binding to protein targets within the skin. There are a range of immunobullous disorders with characteristic morphology that relates to the structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fcad8c3ffaeb7c33ec41203f1667a9
https://europepmc.org/articles/PMC8140695/
https://europepmc.org/articles/PMC8140695/
Publikováno v:
Oxford Textbook of Sjögren's Syndrome
Primary Sjögren’s syndrome (SS) is an autoimmune condition characterized by sicca symptoms affecting mucosal surfaces with or without a spectrum of systemic manifestations. The skin acts as a remarkable window for the diagnosis of systemic autoimm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe773db968781b7d52baac79a98fba7
https://doi.org/10.1093/med/9780198806684.003.0015
https://doi.org/10.1093/med/9780198806684.003.0015
Autor:
William Guesdon, Michael J. Pitcher, Yuan Zhao, Cristina Lebrero-Fernández, Richard Groves, Wayel Jassem, Michelle Kleeman, Susanne Heck, Yogesh Kamra, David J. Fear, David D'Cruz, Richard Ellis, Susan D. John, Ulrich D. Kadolsky, Nedyalko Petrov, Pawan Dhami, Jeremy D. Sanderson, Thomas J Tull, Mats Bemark, Jacqueline Hy Siu, Jo Spencer, Michael D. Robson
Publikováno v:
Spencer, J, Tull, T, Pitcher, M, Guesdon, W, Siu, J HY, Lebraro-Fernandez, C, Zhao, Y, Petrov, N, Heck, S, Ellis, R, Dhami, P, kadolsky, U, Kleeman, M, Kamra, Y, Fear, D, John, S, Jassem, W, Groves, R, Sanderson, J D, Robson, M, D’Cruz, D & Bemark, M 2021, ' Human marginal zone B cell development from early T2 progenitors ', Journal of Experimental Medicine, vol. 218, no. 4, e20202001 . https://doi.org/10.1084/jem.20202001
The Journal of Experimental Medicine
The Journal of Experimental Medicine
This study identifies a developmental trajectory from human IgMhi gut homing transitional 2 cells to marginal zone B cells, all stages of which are affected in patients with severe systemic lupus erythematosus.
B cells emerge from the bone marro
B cells emerge from the bone marro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8c2c762c335e87f1bb70f46e6047e
https://doi.org/10.1101/2020.09.24.311498
https://doi.org/10.1101/2020.09.24.311498