Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Thomas J. Tucker"'
Autor:
Bethany Algayer, Ann O’Brien, Aaron Momose, Dennis J. Murphy, William Procopio, David M. Tellers, Thomas J. Tucker
Publikováno v:
Molecules, Vol 24, Iss 11, p 2079 (2019)
Delivery of macromolecular cargos such as siRNA to the cytosol after endocytosis remains a critical challenge. Numerous approaches including viruses, lipid nanoparticles, polymeric constructs, and various peptide-based approaches have yet to yield a
Externí odkaz:
https://doaj.org/article/5240c8215b514217a9d43fa17ba1d6bd
Autor:
Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood
Publikováno v:
Circulation.
Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering RNA lowers plasma low density lipoprotein-cholesterol, but despite
Autor:
Thomas J. Tucker, Nianyu Li, Scott P. Salowe, Harold B. Wood, Danila Branca, Alan S. Bass, Rupesh P. Amin, BethAnn Murphy, Aurash Shahripour, Angela Kerekes, Abbas Walji, Nicole Buist, Jeffrey T. Kuethe, Huaibing He, Rodger Tracy, Kenneth A. Koeplinger, Weixun Wang, Bhavana Bhatt, Candice Alleyne, Sookhee Ha, Douglas G. Johns, Elisabetta Bianchi, Chengwei Wu, Peter Orth, Tjerk Bueters, Yusheng Xiong, Hratch J. Zokian, Michael J. Hafey, Mark W. Embrey, John Higgins
Publikováno v:
Journal of Medicinal Chemistry. 64:16770-16800
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a key regulator of plasma LDL-cholesterol (LDL-C) and a clinically validated target for the treatment of hypercholesterolemia and coronary artery disease. Starting from second-generation l
Publikováno v:
Transactions of the American Mathematical Society. 374:733-752
Let $K$ be the function field of a smooth, irreducible curve defined over $\overline{\mathbb{Q}}$. Let $f\in K[x]$ be of the form $f(x)=x^q+c$ where $q = p^{r}, r \ge 1,$ is a power of the prime number $p$, and let $\beta\in \overline{K}$. For all $n
Autor:
Thomas J. Tucker, Dragos Ghioca
Publikováno v:
Bulletin of the Australian Mathematical Society. 103:154-161
We advance a new conjecture in the spirit of the dynamical Manin–Mumford conjecture. We show that our conjecture holds for all polarisable endomorphisms of abelian varieties and for all polarisable endomorphisms of $(\mathbb{P}^{1})^{N}$. Furthermo
Autor:
Patrick Ingram, Thomas J. Tucker, Joseph H. Silverman, Rafe Jones, Robert L. Benedetto, Michelle Manes
Publikováno v:
Bulletin of the American Mathematical Society. 56:611-685
Arithmetic dynamics is the study of number theoretic properties of dynamical systems. A relatively new field, it draws inspiration partly from dynamical analogues of theorems and conjectures in classical arithmetic geometry and partly from p p -adic
Publikováno v:
Mathematical Research Letters. 26:949-971
Autor:
Abbas Walji, Sonia DelRizzo, Elisabetta Bianchi, Jonathan D. Mortison, Vladimir Simov, Yingzi Yue, Thomas J. Tucker, Peter Goldenblatt, Alexander Stoeck, Raffaele Ingenito, Edward DiNunzio, Christopher Sondey, Hui Wan, Erin F. DiMauro, Venkat Sriraman, Victor Serebrov, My Sam Mansueto, Scott A. Johnson, Todd Mayhood, Guo Feng, Michael D. Altman
Publikováno v:
European journal of medicinal chemistry. 224
Pathway activating mutations of the transcription factor NRF2 and its negative regulator KEAP1 are strongly correlative with poor clinical outcome with pemetrexed/carbo(cis)platin/pembrolizumab (PCP) chemo-immunotherapy in lung cancer. Despite the st
Autor:
Thomas J. Tucker, Andrew Bridy
Publikováno v:
Mathematische Annalen. 373:37-72
Let $K$ be a number field or a function field. Let $f\in K(x)$ be a rational function of degree $d\geq 2$, and let $\beta\in\mathbb{P}^1(K)$. For all $n\in\mathbb{N}\cup\{\infty\}$, the Galois groups $G_n(\beta)=\text{Gal}(K(f^{-n}(\beta))/K)$ embed
Publikováno v:
Pacific Journal of Mathematics. 295:1-15
Given a smooth projective curve C defined over a number field and given two elliptic surfaces E_1/C and E_2/C along with sections P_i and Q_i of E_i (for i = 1,2), we prove that if there exist infinitely many algebraic points t on C such that for som