Výsledky vyhledávání - "Thomas J. Thamann"

Determination by NMR of the binding constant for the molecular complex between alprostadil and α-cyclodextrinImplications for a freeze-dried formulation

Autor: Speaker Stanley M, Thomas J. Thamann, Tore Ramstad, Dirk L. Teagarden, Gary E. Martin, Chad E. Hadden

Publikováno v: International Journal of Pharmaceutics. 296:55-63

A binding constant was determined for the complexation reaction between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD). This constant was used to calculate the fraction PGE1 free upon reconstitution of Caverject dual chamber syringe, indicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3d425568cd213e1b8b8907d512c9db
https://doi.org/10.1016/j.ijpharm.2005.02.018

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Solid-State Photodegradation of Bovine Somatotropin (Bovine Growth Hormone): Evidence for Tryptophan-Mediated Photooxidation of Disulfide Bonds

Autor: Hageman Michael J, Brian L. Miller, Lorena B. Barron, Thomas J. Thamann, Christian Schöneich

Publikováno v: Journal of Pharmaceutical Sciences. 92:1698-1709

Lyophilized recombinant bovine somatotropin (rbST; bovine growth hormone) is sensitive to photoinduced degradation. The underlying mechanisms of these processes are identified and presented. Lyophilized rbST was photolyzed with near-ultraviolet (UV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d79847e592d081ccc1566171ffd8e0c
https://doi.org/10.1002/jps.10418

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Structural characterization of a degradation product of tin ethyl etiopurpurin (SnET2): Comparison of the long-range heteronuclear correlations detected using conventional GHMBC and IMPEACH-MBC in conjunction with submicro NMR probe technology

Autor: Kenneth Rosenqvist, Chad E. Hadden, Mako N. Masuno, Gary E. Martin, Thomas J. Thamann, Brian D. Kaluzny, Wayne K. Duholke, Phillip E. Sanders, Byron C. Robinson

Publikováno v: Journal of Heterocyclic Chemistry. 40:389-393

During the terminal heat sterilization of the lipid emulsion final dose formulation of the photodynamic therapeutic (PDT) agent tin ethyl etiopurpurin (SnET2), a new degradant was observed at very low levels. The degradant, which was prone to photo-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67f18e8282f148573bf48e9d94aba013
https://doi.org/10.1002/jhet.5570400233

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Identification of degradants of a complex alkaloid using NMR cryoprobe technology and ACD/structure elucidator

Autor: Bruce A. Stiemsma, Antony J. Williams, Eduard R. Martirosian, Thomas J. Thamann, Sergey G. Molodtsov, Gary E. Martin, David J. Russell, Brian D. Kaluzny, Paul L. Schiff, Chad E. Hadden, Ronald C. Crouch, Kirill A. Blinov, Mikhail E. Elyashberg, Jane E. Guido, Wayne K. Duholke

Publikováno v: Journal of Heterocyclic Chemistry. 39:1241-1250

Identification of degradants of pharmaceuticals is a necessary challenge of the drug development process following the subjection of candidate molecules to a variety of physico-chemical stresses. It would be desirable to be able to conduct such studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e3e43caa8b71528baa159a9d497e9d1
https://doi.org/10.1002/jhet.5570390619

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Vibrational spectroscopic studies of solid recombinant bovine growth hormone and related growth hormone analogs

Autor: Robert S Chao, Thomas J. Thamann

Publikováno v: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 55:2261-2270

Infrared and Raman spectra have been obtained for lyophilized recombinant bovine growth hormone (r-bGH), partially reduced, and completely reduced r-bGH, plus a tryptic digest fragment of r-bGH. Amide I and II data indicate r-bGH to have substantial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556b75854ffa3e39ef2624c3f8a032e1
https://doi.org/10.1016/s1386-1425(99)00047-5

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Characterization of a trace by-product of the synthesis of the protease inhibitor tipranavir (PNU-140690)

Autor: Thomas J. Thamann, Wayne K. Duholke, Brian D. Kaluzny, Russell H. Robins, Jane E. Guido, Bruce A. Pearlman, Frank W. Crow, Chad E. Hadden, Gary E. Martin

Publikováno v: Journal of Heterocyclic Chemistry. 36:1107-1114

TipranavirTM (PNU-140690) is a protease inhibitor under clinical investigation for the treatment of human acquired immunodeficiency syndrome (AIDS). During scale-up synthesis of clinical quantities of the bulk drug, a colored, transient by-product of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3a6cd94e9f57f059ddc9d5eaca9726d
https://doi.org/10.1002/jhet.5570360448

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A vibrational spectroscopic assignment of the disulfide bridges in recombinant bovine growth hormone and growth hormone analogs

Autor: Thomas J. Thamann

Publikováno v: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 55:1661-1666

Disulfide stretching vibrations for bovine growth hormone (bGH) occur in a vibrational envelope centered at 540 cm −1 which spans 480–580 cm −1 . A multitude of vibrational bands present in this envelope, that are not related to disulfide stret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bdfde6e26612236e97c4b93c8fd981
https://doi.org/10.1016/s1386-1425(98)00322-9

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Structural identification of a novel degradant of the antibiotic pirlimycin formed under thermal stress conditions

Autor: Constance G. Chidestere, James R. Blinn, John W. Hallberg, Anne M. Cooper, Wayne K. Duholke, Frank W. Crow, Richard F. Smith, Gary E. Martin, Thomas J. Thamann

Publikováno v: Journal of Heterocyclic Chemistry. 36:1049-1055

The structure of a novel, thermally-induced degradant of the antibiotic pirlimycin is presented. The degradant was discovered during thermal stress stability testing of pirlimycin. The structure was determined using high resolution mass spectrometry,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e16c336ad2575431f412f644f2102e84
https://doi.org/10.1002/jhet.5570360436

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Complete spectroscopic structural characterization of novobiocin, isonovobiocin, decarbamylnovobiocin, 2″-(o-Carbamyl)novobiocin, and novobiocin-2″,3″-carbonate

Autor: Chad E. Hadden, Frank W. Crow, David A. Hahn, Richard F. Smith, Christopher S. Mallory, Kathleen A. Farley, Gary E. Martin, Thomas J. Thamann, Brian D. Kaluzny, Wayne K. Duholke

Publikováno v: Journal of Heterocyclic Chemistry. 36:365-370

The rigorous structural characterization of novobiocin, is reported using mass spectrometric, infrared and nmr spectroscopic analysis. Complete nmr assignments are reported. Previous reports in the literature had left some quaternary carbon resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d087b9699c459d4111e593965aca6978
https://doi.org/10.1002/jhet.5570360206

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Susceptibility of morpholine substituents to photo-oxidative decomposition-identification of photo-oxidative degradants of linezolid (PNU-100766)

Autor: Sims Sandra M, Brian E. Thompson, Thomas J. Thamann, Jane E. Guido, Tsutoma Tahara, Wayne K. Duholke, Yukimi Noro, Kathleen A. Farley, Brian D. Kaluzny, Russell H. Robins, Phil B. Bowman, Gary E. Martin, Toshihide Nishimura

Publikováno v: Journal of Heterocyclic Chemistry. 36:265-270

Parenteral formulations of linezolid (PNU-100766), a novel (S)-3-(4′-fluorophenyl)-5-N-acetamidomethyloxazolidin-2-one antibiotic, were subjected to photo-stability testing as required by ICH guidelines. Direct, reversed phase chromatographic evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72636ad3f1038ee421252fdf4acd3d23
https://doi.org/10.1002/jhet.5570360140

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