Toward operationalizing deficient emotional self-regulation in newly referred adults with ADHD: A receiver operator characteristic curve analysis

Autor: Joseph Biederman, Maura DiSalvo, K. Yvonne Woodworth, Ronna Fried, Mai Uchida, Itai Biederman, Thomas J. Spencer, Craig Surman, Stephen V. Faraone

Publikováno v: European Psychiatry, Vol 63 (2020)

AbstractBackground.A growing body of research suggests that deficient emotional self-regulation (DESR) is common and morbid among attention-deficit/hyperactivity disorder (ADHD) patients. The main aim of the present study was to assess whether high a

Externí odkaz: https://doaj.org/article/30a1bb099a244585b3029dd6f8300a4a

Attention and working memory deficits in a perinatal nicotine exposure mouse model.

Autor: Lin Zhang, Thomas J Spencer, Joseph Biederman, Pradeep G Bhide

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0198064 (2018)

BACKGROUND:Cigarette smoking by pregnant women is associated with a significant increase in the risk for cognitive disorders in their children. Preclinical models confirm this risk by showing that exposure of the developing brain to nicotine produces

Externí odkaz: https://doaj.org/article/3ed21359736f4b03ae1e311bfd964f68

No rest for the weary: Prevalence, impact and nature of sleep problems among young people at risk of psychosis

Autor: Thomas J. Spencer, Isaac O. Akande, Eleanor Nuzum, Stefania Tognin, Ryan Hammoud

Publikováno v: Early Intervention in Psychiatry. 16:651-658

Aims Sleep problems are common in people with a psychosis-spectrum diagnosis and are associated with worse psychotic symptoms and lower quality of life. Sleep problems are also frequent in individuals at a clinical high risk for psychosis (CHR-P) how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6295bd7d7225757a4549ec4e2fc7d770
https://doi.org/10.1111/eip.13210

Lower speech connectedness linked to incidence of psychosis in people at clinical high risk

Autor: Natália Bezerra Mota, Sarah E. Morgan, Arsime Demjaha, Lucia Valmaggia, Andrea De Micheli, Paolo Fusar-Poli, Kelly M. J. Diederen, Dominic Oliver, Sara Weinstein, Grazia Rutigliano, Bethany Thompson, Thomas J. Spencer, Fern Day, Philip McGuire

Publikováno v: Schizophr Res

Formal thought disorder is a cardinal feature of psychotic disorders, and is also evident in subtle forms before psychosis onset in individuals at clinical high-risk for psychosis (CHR-P). Assessing speech output or assessing expressive language with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741861e13b52f3133f809033f2e3c5b8
https://doi.org/10.1016/j.schres.2020.09.002

Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis

Autor: Graham K. Murray, Hisham Ziauddeen, H.J. Taverne, J. Haarsma, Ian M. Goodyer, Teresa Katthagen, J.D. Griffin, Thomas J. Spencer, Kelly M. J. Diederen, C Miller, Paul C. Fletcher

Publikováno v: Molecular Psychiatry
Haarsma, J, Fletcher, P, Griffin, J, Taverne, H, Ziauddeen, H, Spencer, T, Miller, C, Katthagen, T, Goodyear, I, Diederen, K & Murray, G 2020, ' Precision-weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-14 . https://doi.org/10.1038/s41380-020-0803-8

Recent theories of cortical function construe the brain as performing hierarchical Bayesian inference. According to these theories, the precision of prediction errors plays a key role in learning and decision-making, is controlled by dopamine and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbf3f3bf4dc6c9037e0d05bc58da189
http://europepmc.org/articles/PMC8589669