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pro vyhledávání: '"Thomas J. Snowden"'
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 45:537-555
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales. To address the issue of mo
Publikováno v:
Bulletin of Mathematical Biology
Complex models of biochemical reaction systems have become increasingly common in the systems biology literature. The complexity of such models can present a number of obstacles for their practical use, often making problems difficult to intuit or co