Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Thomas J. Schuetz"'
Autor:
Diana I. Albu, Benjamin J. Wolf, Yan Qin, Xianzhe Wang, Amy Daniel Ulumben, Mei Su, Vivian Li, Eirene Ding, Jose Angel Gonzalo, Jason Kong, Ruturaj Jadhav, Nelly Kuklin, Alberto Visintin, Bing Gong, Thomas J. Schuetz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTCombinatorial strategies, such as targeting different immune checkpoint receptors, hold promise to increase the breadth and duration of the response to cancer therapy. Here we describe the preclinical evaluation of CTX-8371, a protein constru
Externí odkaz:
https://doaj.org/article/5e1ca35cffdd474daf5caef1c125a47e
Autor:
David Monteith, Emily C. Collins, Corinne Vandermeulen, Anne Van Hecken, Eyas Raddad, Joel C. Scherer, David Grayzel, Thomas J. Schuetz, Jan de Hoon
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Background: Calcitonin gene-related peptide (CGRP) is pivotal in the pathophysiology of migraine headaches and represents a promising target for migraine treatment. The humanized monoclonal antibody galcanezumab (LY2951742) binds to CGRP and may be e
Externí odkaz:
https://doaj.org/article/575cfbd32890489aa7734d36b48339e5
Targeting the DLL/Notch Signaling Pathway in Cancer: Challenges and Advances in Clinical Development
Publikováno v:
Molecular cancer therapeutics. 22(1)
The DLL/Notch signaling pathway plays an important role in cancer as a key driver in maintaining cancer stemness and inducing tumor angiogenesis. Many different types of DLL/Notch inhibitors have been developed and explored in clinical trials for can
A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function
Publikováno v:
Molecular and Cellular Biology. 15:3354-3362
Human heat shock factor 1 (HSF1) stimulates transcription from heat shock protein genes following stress. We have used chimeric proteins containing the GAL4 DNA binding domain to identify the transcriptional activation domains of HSF1 and a separate
Publikováno v:
Biochemistry. 34:1902-1911
A major regulatory step in the heat-induced transcription of heat shock protein (hsp) genes in eukaryotes is the activation of heat shock factor (HSF). In metazoans and Schizosaccharomyces pombe, HSF is present in unstressed cells but is unable to bi
Publikováno v:
Genes & Development. 5:1285-1298
Regulatory factors must contend with chromatin structure to function. Although nucleosome structure and position on promoters can be important in determining factor access, the intrinsic ability of factors to bind to nucleosomal DNA might also play a
Publikováno v:
Molecular and Cellular Biology. 11:281-288
The heat shock response appears to be universal. All eucaryotes studied encode a protein, heat shock factor (HSF), that is believed to regulate transcription of heat shock genes. This protein binds to a regulatory sequence, the heat shock element, th
Publikováno v:
Molecular and Cellular Biology. 7:1530-1534
A factor found in nuclear extracts of human cells bound to the heat shock element of a human heat shock protein 70 gene. The level of this factor was significantly increased after heat shock. This induction was rapid and was not blocked by cyclohexim
Publikováno v:
Nature. 335:372-375
The human heat-shock factor (HSF) regulates heat-shock genes in response to elevated temperature. When human cells are heated to 43 degrees C, HSF is modified post-translationally from a form that does not bind DNA to a form that binds to a specific
Publikováno v:
Nature. 336:184-184