Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas J. R. Frith"'
Autor:
Dylan Stavish, Charlotta Böiers, Christopher Price, Thomas J. R. Frith, Jason Halliwell, Ingrid Saldaña-Guerrero, Jason Wray, John Brown, Jonathon Carr, Chela James, Ivana Barbaric, Peter W. Andrews, Tariq Enver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias b
Externí odkaz:
https://doaj.org/article/49cf589d5cb741e6a087de76d2e33465
Autor:
Jonathon Carr, Jason Wray, Chela James, Christopher J. Price, Jason A. Halliwell, Charlotta Böiers, Tariq Enver, John Brown, Dylan Stavish, Thomas J. R. Frith, Peter W. Andrews, Ivana Barbaric, Ingrid Saldaña-Guerrero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explore mesoderm lineage-bias within the human pluripotent stem cell compartment. We ide
Autor:
Oliver J. Bower, Zoe Hewitt, Peter W. Andrews, Sherif F. El-Khamisy, Paul J. Gokhale, Dylan Stavish, Jason A. Halliwell, Christopher J. Price, Thomas J. R. Frith, Owen Laing, Ivana Barbaric
Publikováno v:
Stem Cell Reports
Summary Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage d
Autor:
James O.S. Hackland, Antigoni Gogolou, Conor J. McCann, Alan J. Burns, Anestis Tsakiridis, Nikhil Thapar, Peter W. Andrews, Thomas J. R. Frith, Ivana Barbaric, Harry Moore, Zoe Hewitt
Publikováno v:
Stem Cell Reports, 15(3), 557-565. Cell Press
Stem Cell Reports
Stem Cell Reports
Summary The enteric nervous system (ENS) is derived primarily from the vagal neural crest, a migratory multipotent cell population emerging from the dorsal neural tube between somites 1 and 7. Defects in the development and function of the ENS cause
Autor:
Ilaria Granata, Ichcha Manipur, Thomas J. R. Frith, Matthew Wind, Mario Rosario Guarracino, Alessandro Bertero, Antigoni Gogolou, Florian Halbritter, Anestis Tsakiridis, Maria Guarini, Filip J. Wymeersch, Celine Souilhol, Minoru Takasato, Christoph Bock
The neural crest (NC) is an important multipotent embryonic cell population and its impaired specification leads to various developmental defects, often in an anteroposterior (A-P) axial level-specific manner. The mechanisms underlying the correct A-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe652373bbdbde3c1b2e669fdd76fc62
https://doi.org/10.1101/2021.09.24.461516
https://doi.org/10.1101/2021.09.24.461516
Autor:
Nikhil Thapar, Peter W. Andrews, Thomas J. R. Frith, Ivana Barbaric, Alan J. Burns, Antigoni Gogolou, Conor J. McCann, Anestis Tsakiridis, James O.S. Hackland
SummaryThe enteric nervous system (ENS) is derived primarily from the vagal neural crest, a migratory multipotent cell population emerging from the dorsal neural tube between somites 1-7. Defects in the development and function of the ENS give rise t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874a0cd0e55d1845170ac684c0e3a79b
https://doi.org/10.1101/819748
https://doi.org/10.1101/819748
Autor:
Christopher J. Price, John Brown, Peter W. Andrews, Dylan Stavish, Charlotta Böiers, Tariq Enver, Thomas J. R. Frith, Ivana Barbaric, Chela James, Jason A. Halliwell, Jonathon Carr
We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explored mesoderm lineage-bias within the human pluripotent stem cell compartment. We id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1d6945651ecbb0852de029cb3426d5
Autor:
Patrick B. Shelar, James O.S. Hackland, Maneeshi S. Prasad, Thomas J. R. Frith, Martín I. García-Castro, Rebekah M. Charney, Nabjot Sandhu, Gustavo A. Gomez
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 920-933 (2019)
Summary: The neural crest is a transient embryonic tissue that gives rise to a multitude of derivatives in an axially restricted manner. An in vitro counterpart to neural crest can be derived from human pluripotent stem cells (hPSCs) and can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c349667b723e0aecac6aa866a829e5a7
https://europepmc.org/articles/PMC6524753/
https://europepmc.org/articles/PMC6524753/
Autor:
Amit Chandra, Venkat Pisupati, Lynn Csontos, Jason A. Halliwell, Glyn Stacey, Mark J.S. McCall, Zoe Hewitt, Malin Parmar, Giulio Cossu, M Beatrice Panico, Ravenska Wagey, Harry Moore, Oliver Thompson, Peter W. Andrews, Valentin P. Shichkin, Thomas J. R. Frith, Ivana Barbaric, Francesco Tedesco, Alison Stacey, Charlotta Böiers
Publikováno v:
Stacey, G N, Andrews, P W, Barbaric, I, Boiers, C, Chandra, A, Cossu, G, Csontos, L, Frith, T J, Halliwell, J A, Hewitt, Z, McCall, M, Moore, H D, Parmar, M, Panico, M B, Pisupati, V, Shichkin, V P, Stacey, A R, Tedesco, F S, Thompson, O & Wagey, R 2019, ' Stem cell culture conditions and stability : A joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform ', Regenerative Medicine, vol. 14, no. 3, pp. 243-255 . https://doi.org/10.2217/rme-2019-0001
Regenerative medicine
Regenerative Medicine
Regenerative medicine
Regenerative Medicine
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18eff64c36c3388d3bb4bde8756340e0
https://www.research.manchester.ac.uk/portal/en/publications/stem-cell-culture-conditions-and-stability(952cea45-8afc-4e69-a2ba-ee8a49560aa5).html
https://www.research.manchester.ac.uk/portal/en/publications/stem-cell-culture-conditions-and-stability(952cea45-8afc-4e69-a2ba-ee8a49560aa5).html
Publikováno v:
Methods in Molecular Biology ISBN: 9781493994113
The neural crest is a transient embryonic tissue that originates from the border of the neural plate prior to delamination and migration throughout the developing embryo, where it contributes to a wide range of different tissues. Defects in neural cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b58d50d4aa4a4b078e7e720b47a28128
https://doi.org/10.1007/978-1-4939-9412-0_4
https://doi.org/10.1007/978-1-4939-9412-0_4