Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas J. Porter"'
Publikováno v:
Analytical Biochemistry. 546:23-27
N-glycan profiling is commonly accomplished by the derivatization of the enzymatically released oligosaccharides with a fluorophore, thereby facilitating their analysis by hydrophilic-interaction liquid chromatography (HILIC). These fluorescent dyes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b8514320c8103a6bfb5e14d4b6b778
https://doi.org/10.1016/j.ab.2018.01.012
https://doi.org/10.1016/j.ab.2018.01.012
Autor:
Weibin Chen, Thomas J. Porter, Robert E. Birdsall, Henry Shion, Frank W. Kotch, Reiko Iizuka, April Xu
Publikováno v:
YAKUGAKU ZASSHI. 137:525-528
Hydrophobic interaction chromatography (HIC) and MS are leading techniques for the characterization of the critical quality attributes (CQA) of antibody-drug conjugates (ADCs). This includes the average drug-to-antibody ratio (DAR) and drug loading d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baf8da3fab64cc83a0dddaae82483d5
https://doi.org/10.1248/yakushi.16-00255-1
https://doi.org/10.1248/yakushi.16-00255-1
Autor:
Thomas J. Porter, Justine P. Mayo, Laura M. Norman, Alissa L. Coes, Nicholas V. Paretti, Edyth Hermosillo, Bruce Gungle, Jay R. Cederberg, Rachel S. Tucci, Christopher M. Kephart
Publikováno v:
Scientific Investigations Report.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d82697525f3995ba5d92e7ad67c0d9
https://doi.org/10.3133/sir20195108
https://doi.org/10.3133/sir20195108
Publikováno v:
mAbs
Cysteine-conjugated antibody-drug conjugates (ADCs) are manufactured using controlled partial reduction and conjugation chemistry with drug payloads that typically occur in intervals of 0, 2, 4, 6, and 8. Control of heterogeneity is of particular imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd390f7b5d318bb3687390cacdf4de7
https://doi.org/10.1080/19420862.2015.1083665
https://doi.org/10.1080/19420862.2015.1083665
Publikováno v:
Analytical Biochemistry. 360:75-83
A unique, late-eluting "basic peak" (relative to the "main peak") was observed by weak cation exchange-HPLC (WCX) for a recombinant monoclonal antibody (mAb) sample. Peak fractions were collected, desalted, and analyzed by high-resolution MS using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d992a2b474c19984d35025f9eef3e1
https://doi.org/10.1016/j.ab.2006.10.012
https://doi.org/10.1016/j.ab.2006.10.012
Autor:
Jason C. Rouse, Heyi Li, Toni Duffy, Jianming Mo, Kelly N. Toler, Thomas J. Porter, Chee-Keng Ng, Andrew Saati, Tonya Matlosz, Tanya Q. Shang, Xi Lin, Jennifer Schenk
Publikováno v:
Journal of pharmaceutical sciences. 103(7)
A highly robust hydrophilic interaction liquid chromatography (HILIC) method that involves both fluorescence and mass spectrometric detection was developed for profiling and characterizing enzymatically released and 2‐aminobenzamide (2‐AB)‐deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c187164acfaf4b9c15afdfdbc196c9
https://pubmed.ncbi.nlm.nih.gov/24840237
https://pubmed.ncbi.nlm.nih.gov/24840237
Autor:
Tanya Shang, Yin Luo, Jason C. Rouse, Stephen W. Raso, Thomas J. Porter, Chee-Keng Ng, John Steckert, Tatjana Matejic, Brian Nunnally
Appropriate and complete analysis and characterization of biopharmaceutical proteins are important to the control of their safety, purity, potency, stability, and overall quality. This chapter reviews the methodologies that are used to characterize i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6736f9654517223b0264d81562092121
https://doi.org/10.1016/b978-0-12-375680-0.00008-5
https://doi.org/10.1016/b978-0-12-375680-0.00008-5
Autor:
Joseph G. Kehoe, Thomas J. Porter
Publikováno v:
National Productivity Review. 13:115-125
Activity-based costing is ideally suited to downsizing and restructuring support departments that handle functions such as personnel, accounting, administration, and materials management. Using the Charleston, South Carolina, Naval Shipyard as an exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f48c8a79e72a9984efaae72e63d2ea42
https://doi.org/10.1002/npr.4040130113
https://doi.org/10.1002/npr.4040130113
Autor:
Jin Xu, Boris Tchernychev, Gray D. Shaw, Qinheng Huang, Thomas J. Porter, Qin Wang, Robert G. Schaub, Michael Wadanoli, Sako Dianne S
Publikováno v:
Thrombosis and haemostasis. 98(2)
SummaryThe interaction between von Willebrand factor (VWF) and platelet glycoprotein Ibα (GPIbα) is a critical step that allows platelet adhesion, activation and subsequent thrombus formation to the injured vessel wall under high-shear conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023e80cc2510d8402bdcd5b401efd2f6
https://pubmed.ncbi.nlm.nih.gov/17721623
https://pubmed.ncbi.nlm.nih.gov/17721623
Autor:
Jason C, Rouse, Joseph E, McClellan, Himakshi K, Patel, Michael A, Jankowski, Thomas J, Porter
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19c9587ce1da7fa7ff5fe9e58f7b0fa1
https://pubmed.ncbi.nlm.nih.gov/16082054
https://pubmed.ncbi.nlm.nih.gov/16082054