Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas J. Pohl"'
Autor:
Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into w
Externí odkaz:
https://doaj.org/article/08adf8bbba7940a8b4cc3c5378c32316
Autor:
Phong Lan Thao Tran, Thomas J. Pohl, Chi-Fu Chen, Angela Chan, Sebastian Pott, Virginia A. Zakian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in prom
Externí odkaz:
https://doaj.org/article/2e8870bb59154364bb030628f649dba0
Publikováno v:
Genetics
Two common features of centromeres are their transcription into noncoding centromere RNAs (cen-RNAs) and their assembly into nucleosomes that contain a centromere-specific histone H3 (cenH3). Here, we show that Saccharomyces cerevisiae cen-RNA was pr
Publikováno v:
Genetics. 211:105-119
Pif1 family helicases are found in virtually all eukaryotes. Saccharomyces cerevisiae (Sc) encodes two Pif1 family helicases, ScPif1 and Rrm3. ScPif1 is multifunctional, required not only for maintenance of mitochondrial DNA but also for multiple dis
Autor:
Virginia A. Zakian, Chi Fu Chen, Phong Lan Thao Tran, Sebastian Pott, Thomas J. Pohl, Angela Chan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3 promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify a new role for the Pif1 helicase: promotion of replication and suppression o
Autor:
Virginia A. Zakian, Thomas J. Pohl
Publikováno v:
DNA Repair (Amst)
An R-loop is a structure that forms when an RNA transcript stays bound to the DNA strand that encodes it and leaves the complementary strand exposed as a loop of single stranded DNA. R-loops accumulate when the processing of RNA transcripts is impair
Publikováno v:
Genetics
Pif1 family helicases are found in virtually all eukaryotes. Saccharomyces cerevisiae (Sc) encodes two Pif1 family helicases, ScPif1 and Rrm3. ScPif1 is multifunctional, required not only for maintenance of mitochondrial DNA but also for multiple dis
Autor:
Bonita J. Brewer, Elizabeth X. Kwan, Thomas J. Pohl, M. K. Raghuraman, Joseph C. Sanchez, Haley M. Amemiya
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 10, p e1007041 (2017)
PLoS Genetics, Vol 13, Iss 10, p e1007041 (2017)
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5). These genes encode components of the pre-replication complex, which assembles at origins
Publikováno v:
G3: Genes|Genomes|Genetics
Eukaryotic origins of DNA replication undergo activation at various times in S-phase, allowing the genome to be duplicated in a temporally staggered fashion. In the budding yeast Saccharomyces cerevisiae, the activation times of individual origins ar
Autor:
Thomas J. Pohl, Leah L. Larkin
Publikováno v:
Journal of the Kansas Entomological Society. 79:107-112
A new species of andrenid bee (Hymenoptera: Andrenidae), Andrena (Callandrena) jazleya Pohl and Larkin, n. sp., is described from southwestern Mexico. The species is closely related to A. brooksi Larkin and A. reflexa Cresson, but can be easily disti