Zobrazeno 1 - 10 of 48 pro vyhledávání: '"Thomas J. Piggot"'
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Akademický článek
Overlay databank unlocks data-driven analyses of biomolecules for all
Autor: Anne M. Kiirikki, Hanne S. Antila, Lara S. Bort, Pavel Buslaev, Fernando Favela-Rosales, Tiago Mendes Ferreira, Patrick F. J. Fuchs, Rebeca Garcia-Fandino, Ivan Gushchin, Batuhan Kav, Norbert Kučerka, Patrik Kula, Milla Kurki, Alexander Kuzmin, Anusha Lalitha, Fabio Lolicato, Jesper J. Madsen, Markus S. Miettinen, Cedric Mingham, Luca Monticelli, Ricky Nencini, Alexey M. Nesterenko, Thomas J. Piggot, Ángel Piñeiro, Nathalie Reuter, Suman Samantray, Fabián Suárez-Lestón, Reza Talandashti, O. H. Samuli Ollila
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their applications are often limited by the lack of suitable training data in programmatically accessible format. Here we propose an effective solutio
Externí odkaz: https://doaj.org/article/acfa193917a24cbab8ffde269f7d7c0d
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3
Akademický článek
Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study.
Autor: Nils A Berglund, Thomas J Piggot, Damien Jefferies, Richard B Sessions, Peter J Bond, Syma Khalid
Publikováno v: PLoS Computational Biology, Vol 11, Iss 4, p e1004180 (2015)
Antimicrobial peptides are small, cationic proteins that can induce lysis of bacterial cells through interaction with their membranes. Different mechanisms for cell lysis have been proposed, but these models tend to neglect the role of the chemical c
Externí odkaz: https://doaj.org/article/02dbca3f73674379a2ad0e0223f8f2a2
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4
Inverse Conformational Selection in Lipid–Protein Binding
Autor: Matti Javanainen, Salla I. Virtanen, Fernando Favela-Rosales, Chris Papadopoulos, Antonio Peón, Amélie Bacle, Anne M. Kiirikki, Patrick F.J. Fuchs, O. H. Samuli Ollila, Pavel Buslaev, Ángel Piñeiro, Rebeca García-Fandiño, Paula Milán Rodríguez, Tiago Mendes Ferreira, Markus S. Miettinen, Jesper J. Madsen, Josef Melcr, Ivan Gushchin, Thomas J. Piggot
Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2021, 143 (34), pp.13701-13709. ⟨10.1021/jacs.1c05549⟩
Journal of the American Chemical Society, 143(34), 13701-13709. AMER CHEMICAL SOC
Journal of the American Chemical Society, American Chemical Society, 2021, 143 (34), pp.13701-13709. ⟨10.1021/jacs.1c05549⟩
International audience; Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example, in carriers of mRNA v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d9345531ed2d3d157ba5bfda9d2f8b
https://hal.sorbonne-universite.fr/hal-03355166/file/jacs.1c05549.pdf
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5
Headgroup Structure and Cation Binding in Phosphatidylserine Lipid Bilayers
Autor: Jesper J. Madsen, Pavel Buslaev, Josef Melcr, Batuhan Kav, Fernando Favela-Rosales, Jukka Määttä, Markus S. Miettinen, O. H. Samuli Ollila, Tiago Mendes Ferreira, Matti Javanainen, Hanne S. Antila, Ricky Nencini, Ivan Gushchin, Thomas J. Piggot
Publikováno v: Journal of Physical Chemistry B, 123(43), 9066-9079. AMER CHEMICAL SOC
Phosphatidylserine (PS) is a negatively charged lipid type commonly found in eukaryotic membranes, where it interacts with proteins via nonspecific electrostatic interactions as well as via specific binding. Moreover, in the presence of calcium ions,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df121a8ec2484c4ce66e6794af1d1ac
https://doi.org/10.1021/acs.jpcb.9b06091
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7
Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR
Autor: John E.H. Tattersall, Max Epstein, Christopher M. Timperley, A. Christopher Green, Isabel Bermudez, Karan Bali, Philip C. Biggin, Thomas J. Piggot, Mike Bird
Publikováno v: Toxicology letters. 340
Organophosphorus nerve agents (NAs) are the most lethal chemical warfare agents and have been used by state and non-state actors since their discovery in the 1930s. They covalently modify acetylcholinesterase, preventing the breakdown of acetylcholin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb7af06bca6490271003744b2f384e4
https://pubmed.ncbi.nlm.nih.gov/33482275
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8
Structural correlates of human muscle nicotinic acetylcholine receptor subunit assembly mediated by δ(+) interface residues
Autor: Max Epstein, Thomas J. Piggot, David Beeson, Isabel Bermudez, Susan Maxwell, Philip C. Biggin
Muscle nicotinic acetylcholine receptors are a class of heteropentameric ligand-gated cation channels with constituent subunits adopting a fixed stoichiometric arrangement. The specific amino acid residues that govern subunit ordering are however, on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8afe53b9b7fb2f2c9a4ee5e3527a12e0
https://doi.org/10.1101/2020.06.11.145466
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9
Braun’s Lipoprotein Facilitates OmpA Interaction with the Escherichia coli Cell Wall
Autor: Firdaus Samsudin, Thomas J. Piggot, Syma Khalid, Alister Boags
Publikováno v: Biophysical Journal. 113:1496-1504
Gram-negative bacteria such as Escherichia coli are protected by a complex cell envelope. The development of novel therapeutics against these bacteria necessitates a molecular level understanding of the structure-dynamics-function relationships of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1759e1da5d937235b6cb6ea33431ba97
https://doi.org/10.1016/j.bpj.2017.08.011
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