Výsledky vyhledávání - "Thomas J. Novitsky"

Biomedical Implications for Managing the Limulus polyphemus Harvest Along the Northeast Coast of the United States

Autor: Thomas J. Novitsky

Publikováno v: Changing Global Perspectives on Horseshoe Crab Biology, Conservation and Management ISBN: 9783319195414

North American horseshoe crabs (Limulus polyphemus) have been continuously harvested in Massachusetts for the production of Limulus amebocyte lysate (LAL); since the mid 1970s as bait for American eel (Anguilla rostrata); and since the mid 1990s as b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a223e045d9c5a89819fe8ff9180d3
https://doi.org/10.1007/978-3-319-19542-1_28

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Production of recombinant endotoxin neutralizing protein in Pichia pastoris and methods for its purification

Autor: Malcolm A. Finkelman, Charles R Legg, Erik J. Paus, Paul A. Ketchum, Joanne M. Willey, Richard J. Ridge, Thomas J. Novitsky

Publikováno v: Protein Expression and Purification. 26:202-210

Production of recombinant Limulus endotoxin neutralizing protein (rENP) was attained with the GS115 methylotrophic strain of Pichia pastoris transformed with a plasmid, bearing multiple ENP gene copies. The synthetic gene for Limulus ENP was cloned i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac818fd96e59b1c1cc0d102d12e4839
https://doi.org/10.1016/s1046-5928(02)00508-9

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Reversible binding of heparin to the loop peptide of endotoxin neutralizing protein

Autor: Erik J. Paus, Paul A. Ketchum, Thomas J. Novitsky, Richard J. Ridge

Publikováno v: Journal of Endotoxin Research. 6:17-23

Endotoxin neutralizing protein (ENP) from Limulus polyphemus is an amphipathic, 11.8 kDa protein with an isoelectric point of 10.2. ENP neutralizes lipopolysaccharide (LPS) and possesses antibacterial activity against Gram-negative bacteria. Heparin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5f12c59cfd3a0057c12633f5c1c2e7
https://doi.org/10.1177/09680519000060010301

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Limulus Amebocyte Lysate Assay for Detection of Endotoxin in Patients with Sepsis Syndrome

Autor: Paul S. Graman, Edgar R. Black, Patricia L. Hibberd, Elizabeth B. Miller, Paul A. Ketchum, Richard D. Moore, David R. Snydman, Paul N. Lanken, Kenneth Sands, Jeffrey Parsonnet, J. Sanford Schwartz, Katherine L. Kahn, Thomas J. Novitsky, David W. Bates

Publikováno v: Clinical Infectious Diseases. 27:582-591

Clinical predictions alone are insufficiently accurate to identify patients with specific types of bloodstream infection; laboratory assays might improve such predictions. Therefore, we performed a prospective cohort study of 356 episodes of sepsis s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f042e6a34c19edb55e4e9f18ee3a2c5a
https://doi.org/10.1086/514713

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A comparison of bactericidal/permeability-versus increasing protein variant recombinant endotoxin-neutralizing protein for the treatment of Escherichia coli sepsis in rats

Autor: Marian N. Marra, Thomas J. Novitsky, Gary R. Fleisher, Richard A. Saladino, Claudette M. Thompson, Anne M. Stack, George R. Siber

Publikováno v: Critical Care Medicine. 25:101-105

Objective: To compare a recombinant bactericidal/permeability-increasing protein variant and a recombinant endotoxin-neutralizing protein. Design: Randomized, blinded, controlled study, using a rat model of sepsis. Setting: Animal research facility.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af4fa2ae5ca53a1d0446c7f63021d5b
https://doi.org/10.1097/00003246-199701000-00020

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High-dose recombinant endotoxin neutralizing protein improves survival in rabbits with Escherichia coli sepsis

Autor: Thomas J. Novitsky, Gary R. Fleisher, Felicia Sattler, Anne M. Stack, Richard A. Saladino, George R. Siber, Claudette M. Thompson

Publikováno v: Critical Care Medicine. 24:1203-1207

Objective To assess the benefit of a recombinant endotoxin neutralizing protein from Limulus polyphemus in treating Gram-negative bacterial sepsis in rabbits. Design Prospective, blinded, controlled, laboratory trial. Setting Animal research laborato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0818d9e114cab87dc34c7966eb4cda5e
https://doi.org/10.1097/00003246-199607000-00023

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Recombinant endotoxin neutralizing protein improves survival from Escherichia coli sepsis in rats

Autor: Andrew B. Onderdonk, Brian K. Hammer, George R. Siber, Jeffrey Parsonnet, Thomas J. Novitsky, Nathan Kuppermann, Douglas S. Nelson, Claudette M. Thompson, Carmen T. Garcia, Gary R. Fleisher, Richard A. Saladino

Publikováno v: Critical Care Medicine. 23:92-98

A recombinant endotoxin neutralizing protein was evaluated for its ability to ameliorate the effects of Escherichia coli sepsis in rats.Prospective, controlled animal trial.Hospital animal research laboratory.Wistar rats, treated with gentamicin 1 hr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9403cca1acd4cc47961f1583b8305c1
https://doi.org/10.1097/00003246-199501000-00017

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