Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas J. Novak"'
Autor:
P. Charukeshi Chandrasekera, George Perry, Robin S.B. Williams, Ann Lam, Alex E. Roher, Martha Clare Morris, Thomas Hartung, David Pamies, Ryan Merkley, Francesca Pistollato, Neal D. Barnard, Thomas J. Novak, Mei-Chun Lai, Gillian R. Langley, Elan L. Ohayon, Eugenia Trushina, Stevan Harnad
Publikováno v:
Oncotarget
Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b808a704c1a414db36dce71b0696b3
https://doi.org/10.18632/oncotarget.9175
https://doi.org/10.18632/oncotarget.9175
Autor:
Lisa DiMichele, Thomas J. Novak
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 37:2756-2771
The reaction of chiral methylbenzyl and napthylethyl isocyanates with a β-adrenoceptor agent having two stereogenic centers and multiple reaction sites was investigated as a means of ascertaining the stereochemical composition of an individual enant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f265b1199b90e6397de208969781cab7
https://doi.org/10.1080/10826076.2013.864978
https://doi.org/10.1080/10826076.2013.864978
Autor:
Thomas J. Novak
Publikováno v:
Stem Cells in Regenerative Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6019f84f09486e564b5f0fb3d4f057
https://doi.org/10.1002/9781118846193.ch10
https://doi.org/10.1002/9781118846193.ch10
Autor:
Thomas J. Novak, Luca Santarelli, Melissa Works, Jos Prickaerts, Dinah Misner, Tanya L. Wallace, Kris Rutten, Arjan Blokland
Publikováno v:
Neuropharmacology, 61(1-2), 138-147. Elsevier Science
3'-5'-Cyclic adenosine monophosphate (cAMP) is known to be an important regulator of synaptic plasticity. The effects of cAMP are mediated through downstream effectors such as protein kinase A (PKA), Ca2+ and cAMP-response element binding protein (CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e416502bed9dec50adcf0a48ea8c7155
https://cris.maastrichtuniversity.nl/en/publications/cc4bc7a1-91d0-4bb8-bbfe-378e39a1b06f
https://cris.maastrichtuniversity.nl/en/publications/cc4bc7a1-91d0-4bb8-bbfe-378e39a1b06f
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 51:78-83
LCMS incorporating a quadrupole time of flight mass spectrometer was used to identify impurities found in a chemical process development sample of a novel integrase inhibitor, raltegravir. The combination of accurate mass measurement in full scan mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9665b0cd16da0df7c6f0ce5a111c0ecd
https://doi.org/10.1016/j.jpba.2009.08.007
https://doi.org/10.1016/j.jpba.2009.08.007
Autor:
Yong Liu, Yadan W. Chen, Artis Klapars, Thomas J. Novak, Lisa F. Frey, Brain Phenix, Kevin R. Campos, Cheng-yi Chen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 49:702-710
Taranabant (MK-0364) is a highly potent and selective cannabinoid-1 receptor (CB-1R) inverse agonist. It is being developed at MerckCompany to treat obesity. The chemical synthesis of MK-0364 drug substance involved the direct coupling of chiral amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d661fdd37309598fd5492cae613c34
https://doi.org/10.1016/j.jpba.2009.01.003
https://doi.org/10.1016/j.jpba.2009.01.003
Autor:
Thomas J. Novak, Arjan Blokland, Kris Rutten, Dinah Misner, Tanya L. Wallace, Luca Santarelli, Melissa Works
Publikováno v:
European Journal of Neuroscience, 28(3), 625-632. Wiley
Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through phosphorylation of cAMP-responsive element binding protein (CREB) is hypothesized to underlie the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80036c68001057bdc5a0f85216224d3c
https://doi.org/10.1111/j.1460-9568.2008.06349.x
https://doi.org/10.1111/j.1460-9568.2008.06349.x
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 44:421-429
Tracking the impurity profile of an active pharmaceutical ingredient (API) is a very important task for all stages of drug development. A systematic approach for tracking impurity profile of API is described. Various real pharmaceutical applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9354e5c4cad72a9d977522f6e37cdc2e
https://doi.org/10.1016/j.jpba.2006.11.004
https://doi.org/10.1016/j.jpba.2006.11.004
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 28:3131-3142
Trifluorophenylacetic acid (TFPAA) was synthesized from 2,4,5‐trifluorophenyl bromide and malonic acid starting materials as part of process development for a pharmaceutical intermediate. Impurity profile methods, sensitive to positional isomers, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf75c80618c6ea899c77a11fa4adc3b
https://doi.org/10.1080/10826070500295278
https://doi.org/10.1080/10826070500295278
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 24:15-28
A rapid and facile carbon dioxide derivatization procedure was developed to stabilize Grignard reagents for reversed-phase liquid chromatographic analysis. Derivatization of the neat Grignard reagent was performed in a septum-sealed vial at 0°C unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dffde61c04ab51cf092f69f8f2be5b2
https://doi.org/10.1081/jlc-100000323
https://doi.org/10.1081/jlc-100000323