Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas J. Morley"'
Autor:
Andreas Geissner, Lars Baumann, Thomas J. Morley, Andrew K. O. Wong, Lyann Sim, Jamie R. Rich, Pauline P. L. So, Edie M. Dullaghan, Etienne Lessard, Umar Iqbal, Maria Moreno, Warren W. Wakarchuk, Stephen G. Withers
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 345-354 (2021)
Externí odkaz:
https://doaj.org/article/8f8cb4dde1d84b6297a419a849de0783
Autor:
Cristian Constantinescu, David Alagille, Caroline Papin, Eiji Sunahara, Shuhei Ikeda, Tatsuki Koike, Maki Miyamoto, John Seibyl, Gilles Tamagnan, Olivier Barret, Thomas J. Morley, Krista Fowles, Patricia E. Cole, Takanobu Kuroita, Toshiya Nishi
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:1148-1156
Purpose Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being pursued
Autor:
David Alagille, Satoru Matsuda, Rina Baba, Gilles Tamagnan, Thomas J. Morley, Yasushi Hattori, Tatsuki Koike, Caroline Papin, Cristian Constantinescu, Alexandra Gouasmat, Vincent M. Carroll, Shinji Iwasaki, Kouta Matsumiya
Publikováno v:
Journal of Medicinal Chemistry. 64:3780-3793
Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediat
Autor:
Vincent M. Carroll, David Gray, John Seibyl, Olivier Barret, Gilles Tamagnan, Timothy J. McCarthy, Lei Zhang, Jenna M. Sullivan, David Alagille, Caroline Papin, Christine M. Sandiego, Cristian Constantinescu, Jianqing Chen, Anabella Villalobos, Thomas J. Morley, Chewah Lee
Publikováno v:
Journal of Nuclear Medicine. 62:1307-1313
Non–catechol-based high-affinity selective dopamine D1 receptor (D1R) agonists were recently described, and candidate PET ligands were selected on the basis of favorable properties. The objective of this study was to characterize in vivo in nonhuma
Autor:
Lyann Sim, Pauline P L So, Edie M Dullaghan, Jamie R. Rich, Stephen G. Withers, Warren W. Wakarchuk, Lars Baumann, Andrew K O Wong, Etienne Lessard, Maria J. Moreno, Umar Iqbal, Andreas Geissner, Thomas J. Morley
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 345-354 (2021)
ACS Central Science
ACS Central Science
The maintenance of therapeutic glycoproteins within the circulatory system is associated, in large part, with the integrity of sialic acids as terminal sugars on the glycans. Glycoprotein desialylation, either by spontaneous cleavage or through host
Autor:
Xianhong Xiang, Cedric Tresse, Thomas J. Morley, Vijay Gottmukkala, Zhengxin Cai, Tyler Teceno, Shil Patel, Olivier Barret, Stephen Krause, Alexandra Gouasmat, Jan Passchier, Songye Li, Vincent M. Carroll, Yiyun Huang, Ashley Knight, Wenjie Zhang
Publikováno v:
Molecular Imaging and Biology. 22:832-841
Current synaptic vesicle 2A (SV2A) positron emission tomography (PET) imaging agents include the nanomolar affinity probes [11C]UCB-J and [18F]UCB-H derived from the anti-epileptic drug levitaracetam (Keppra®). An industry-utilized “de-risking”
Autor:
Francois Benard, Edouard Asselin, Thomas J. Ruth, Leah Penner, Paul Schaffer, Thomas J. Morley
Publikováno v:
Electrometallurgy 2012
Electrochemistry Communications, Vol 15, Iss 1, Pp 78-80 (2012)
Electrochemistry Communications, Vol 15, Iss 1, Pp 78-80 (2012)
This paper details the electrodeposition of metallic molybdenum from an aqueous electrolyte containing molybdate ions. The deposition is performed in an acetate bath that contains a high (up to 10 M) concentration of acetate. The molybdenum deposits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f79287e60e8e56f8494435e9411161
Autor:
Robert A. Comley, Sandra Sanabria, David Alagille, Edilio Borroni, Caroline Papin, Gilles Tamagnan, John Seibyl, Ken Marek, Olivier Barret, Mark A. Mintun, Thomas J. Morley, Nicholas Seneca, Robby M. Weimer, Danna Jennings
Publikováno v:
Journal of Nuclear Medicine. 58:1124-1131
18F-AV-1451 is currently the most widely used of several experimental tau PET tracers. The objective of this study was to evaluate 18F-AV-1451 binding with full kinetic analysis using a metabolite-corrected arterial input function and to compare para
Autor:
H. Sharon Lee, R. M. Baldwin, David Alagille, Caroline Papin, Christine Vala, Vincent M. Carroll, Adriana Tavares, Thomas J. Morley, Xuechun Zhang, Gilles Tamagnan, Cristian Constantinescu, Olivier Barret
Publikováno v:
ChemMedChem. 11:1936-1943
Imaging agents that target adenosine type 2A (A2A ) receptors play an important role in evaluating new pharmaceuticals targeting these receptors, such as those currently being developed for the treatment of movement disorders like Parkinson's disease
Autor:
Gilles Tamagnan, Cristian Constantinescu, Olivier Barret, David Alagille, Thomas J. Morley, Hsiaoju S. Lee, David Thomae, Caroline Papin, Ronald M. Baldwin
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:205-213
Phosphodiesterase (PDE) 4 is the most prevalent PDE in the central nervous system (CNS) and catalyzes hydrolysis of intracellular cAMP, a secondary messenger. By therapeutic inhibition of PDE4, intracellular cAMP levels can be stabilized, and the sym