Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Thomas J. Moehring"'
Publikováno v:
Biochemical Journal. 339:639-647
PACE4 is a member of the eukaryotic subtilisin-like endoprotease family. The expression of human PACE4 in RPE.40 cells (furin-null mutants derived from Chinese hamster ovary K1 cells) resulted in the rescue of a number of wild-type characteristics, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e1d5cf0dc5e9e5e23fed9a36ab28e50
https://doi.org/10.1042/bj3390639
https://doi.org/10.1042/bj3390639
Publikováno v:
Somatic Cell and Molecular Genetics. 24:75-90
The fur gene encodes the endoprotease, furin. We recently demonstrated mutations in both fur alleles in the mutant Chinese hamster ovary (CHO)-K1 strain, RPE.40, and hypothesized that these mutations were responsible for the endoprotease-deficient ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f230a6677a4e3575b26456d1a147855
https://doi.org/10.1023/b:scam.0000007111.46513.70
https://doi.org/10.1023/b:scam.0000007111.46513.70
Publikováno v:
Journal of Biological Chemistry. 272:1344-1348
We addressed the question of whether furin is the endoprotease primarily responsible for processing the human immunodeficiency virus type I (HIV-I) envelope protein gp160 in mammalian cells. The furin-deficient Chinese hamster ovary (CHO)-K1 strain R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1c3f962a94a08ffa738269df369d68
https://doi.org/10.1074/jbc.272.2.1344
https://doi.org/10.1074/jbc.272.2.1344
Publikováno v:
Biochemical Journal. 313:71-76
The low-density-lipoprotein receptor-related protein (LRP) is a multifunctional receptor involved in the clearance of a large number of diverse ligands, including proteases, protease-inhibitor complexes and lipoproteins. The mature receptor is compos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5aeace84b73212b42c8cbda3f120657
https://doi.org/10.1042/bj3130071
https://doi.org/10.1042/bj3130071
Publikováno v:
Journal of Biological Chemistry. 270:23218-23225
Both diphtheria toxin and Pseudomonas exotoxin A inhibit eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in the elongation factor 2 (EF-2) protein. Elongation factor 2 cannot be A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4590f177cafe08140bba5ecfb1c00823
https://doi.org/10.1074/jbc.270.39.23218
https://doi.org/10.1074/jbc.270.39.23218
Publikováno v:
Somatic Cell and Molecular Genetics. 21:1-18
RPE. 40 mutant cells differ from wild-type Chinese hamster ovary (CHO-K1) cells in their increased resistance toPseudomonas exotoxin A and their inability to process the insulin proreceptor and certain viral envelope proproteins. Northern analysis re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489945e2dead8f2cb79434c4abe79206
https://doi.org/10.1007/bf02255818
https://doi.org/10.1007/bf02255818
Publikováno v:
Journal of Biological Chemistry. 269:31831-31835
We have demonstrated that the native proenzymatic form of Pseudomonas exotoxin A can be cleaved at its specific activation site by furin in intact Chinese hamster ovary cells or in vitro by furin in isolated membrane fractions from these cells. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d01c75b8e622e7825f76732e68b908
https://doi.org/10.1016/s0021-9258(18)31770-8
https://doi.org/10.1016/s0021-9258(18)31770-8
Publikováno v:
Journal of Biological Chemistry. 268:24274-24277
Characterization of an endoprotease-deficient mutant Chinese hamster ovary (CHO) cell, designated RPE.40, revealed that it bound less than 10% as much insulin as did its parent, CHO-K1. We examined processing of the endogenous insulin receptor in CHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac2eadc00b56f94109d3c5208e65cac5
https://doi.org/10.1016/s0021-9258(20)80521-3
https://doi.org/10.1016/s0021-9258(20)80521-3
Publikováno v:
Journal of Biological Chemistry. 268:2590-2594
RPE.40 is a strain of mutated CHO-K1 cells with elevated resistance to Pseudomonas exotoxin A, Sindbis virus, and Newcastle disease virus. Virus resistance is due to an inability to cleave precursor viral membrane glycoproteins and produce infectious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d57dfa814298bf78140adab2528dc21b
https://doi.org/10.1016/s0021-9258(18)53815-1
https://doi.org/10.1016/s0021-9258(18)53815-1
Publikováno v:
Somatic Cell and Molecular Genetics. 18:227-231
The histidine residue at position 715 of elongation factor 2 (EF-2) is posttranslationally modified in a series of enzymatic reactions to 2-[3-carboxyamido-3-(trimethylammonio)-propyl]histidine, which has been given the trivial name diphthamide. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f98d82fff5101cc27a0cade188469d
https://doi.org/10.1007/bf01233859
https://doi.org/10.1007/bf01233859