Výsledky vyhledávání - "Thomas J. Mangner"

Akademický článek

Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain.

Autor: Robin Bonomi, Uday Mukhopadhyay, Aleksandr Shavrin, Hsien-Hsien Yeh, Anjoy Majhi, Sajeewa W Dewage, Amer Najjar, Xin Lu, G Andrés Cisneros, William P Tong, Mian M Alauddin, Ren-Shuan Liu, Thomas J Mangner, Nashaat Turkman, Juri G Gelovani

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133512 (2015)

Histone deacetylases (HDAC's) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa deacetylases possess only minimal deacetylase activit

Externí odkaz: https://doaj.org/article/3ab80ca33b63401587d670592377c586

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Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA

Autor: Thomas J. Mangner, Xin Lu, Maxwell T. Laws, Shreya Potukutchi, Jeremy T Llaniguez, David Gelovani, Robin E. Bonomi, Juri G. Gelovani, Swatabdi Kamal

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

HDAC class IIa enzymes (HDAC4, 5, 7, 9) are important for glioma progression, invasion, responses to TMZ and radiotherapy, and prognosis. In this study, we demonstrated the efficacy of PET/CT/(MRI) with [18F]TFAHA for non-invasive and quantitative im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087b945966379f123b016a373af8411d
http://link.springer.com/article/10.1038/s41598-019-40054-2

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Noninvasive quantification of SIRT1 expression–activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI

Autor: Xin Lu, Thomas J. Mangner, Jeremy T Llaniguez, Maxwell T. Laws, David Gelovani, Robin E. Bonomi, Juri G. Gelovani

Publikováno v: Neuro-Oncology Advances

Background Several studies demonstrated that glioblastoma multiforme progression and recurrence is linked to epigenetic regulatory mechanisms. Sirtuin 1 (SIRT1) plays an important role in glioma progression, invasion, and treatment response and is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f1238b1bf236fb86864028eae18a2c
https://doi.org/10.1093/noajnl/vdaa006

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Akademický článek

Assessment of oxidative metabolism in Brown Fat using PET imaging

Autor: Otto eMuzik, Thomas J Mangner, James G Granneman

Publikováno v: Frontiers in Endocrinology, Vol 3 (2012)

Objective: Although it has been believed that brown adipose tissue (BAT) depots disappear shortly after the perinatal period in humans, PET imaging using the glucose analog FDG has shown unequivocally the existence of functional BAT in humans. The ob

Externí odkaz: https://doaj.org/article/69ef6f84df3c4109b260236d21370834

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Molecular Imaging of Sirtuin1 Expression–Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide

Autor: Xin Lu, Otto Muzik, Thomas J. Mangner, Aleksandr Shavrin, Vadim V. Popov, Maxwell T. Laws, David Gelovani, Robin E. Bonomi, Anjoy Majhi, Renshyan Liu, Juri G. Gelovani, Nashaat Turkman

Publikováno v: Journal of Medicinal Chemistry. 61:7116-7130

Sirtuin 1 (SIRT1) is a class III histone deacetylase that plays significant roles in the regulation of lifespan, metabolism, memory, and circadian rhythms and in the mechanisms of many diseases. However, methods of monitoring the pharmacodynamics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e2d5e67a904b5be243b262d3ede9765
https://doi.org/10.1021/acs.jmedchem.8b00253

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Using Radiolabeled 3′-Deoxy-3′-18F-Fluorothymidine with PET to Monitor the Effect of Dexamethasone on Non–Small Cell Lung Cancer

Autor: Jawana M. Lawhorn-Crews, Shirish M. Gadgeel, Christopher I. McHugh, Thomas J. Mangner, Anthony F. Shields, Monica Thipparthi, Jing Li, Janice Akoury, Lisa Polin, Kirk A. Douglas, Manohar Ratnam

Publikováno v: Journal of Nuclear Medicine. 59:1544-1550

Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality in the United States, and pemetrexed-based therapies are regularly used to treat nonsquamous NSCLC. Despite widespread use, pemetrexed has a modest effect on progression-free s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78633ce8a0d1fea8d7cf421833f26332
https://doi.org/10.2967/jnumed.117.207258

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Assessment of Tryptophan Uptake and Kinetics Using 1-(2-18F-Fluoroethyl)-l-Tryptophan and α-11C-Methyl-l-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts

Autor: Csaba Juhász, Neil V. Klinger, Hancheng Cai, Otto Muzik, Yangchun Xin, Sharon K. Michelhaugh, Sandeep Mittal, Thomas J. Mangner, Shaohui Zhang, Anthony R. Guastella, Lisa Polin

Publikováno v: Journal of Nuclear Medicine. 58:208-213

Abnormal tryptophan metabolism via the kynurenine pathway (KP) is involved in the pathophysiology of a variety of human diseases including cancers. α-[11C]-methyl-L-tryptophan (11C-AMT) positron emission tomography (PET) imaging demonstrated increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c3dff35ca7eee84a0fb6e711f9092
https://doi.org/10.2967/jnumed.116.179994

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Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase

Autor: Kirk A. Douglas, Jawana M. Lawhorn-Crews, Seongho Kim, Anthony F. Shields, Jing Li, Thomas J. Mangner, Christopher I. McHugh, Jianmei Wu, Patricia LoRusso

Publikováno v: The Journal of Clinical Pharmacology. 56:1433-1447

FAU, a pyrimidine nucleotide analogue, is a prodrug bioactivated by intracellular thymidylate synthase to form FMAU, which is incorporated into DNA, causing cell death. This study presents a model-based approach to integrating dynamic positron emissi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02973d0ee862d99f38284cd104b447b1
https://doi.org/10.1002/jcph.751

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Using Radiolabeled 3'-Deoxy-3'

Autor: Christopher I, McHugh, Monica R, Thipparthi, Jawana M, Lawhorn-Crews, Lisa, Polin, Shirish, Gadgeel, Janice, Akoury, Thomas J, Mangner, Kirk A, Douglas, Jing, Li, Manohar, Ratnam, Anthony F, Shields

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 59(10)

Non–small cell lung cancer (NSCLC) is a leading cause of cancer mortality in the United States, and pemetrexed-based therapies are regularly used to treat nonsquamous NSCLC. Despite widespread use, pemetrexed has a modest effect on progression-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c658c466d8c75bf5eab5167d6d77ed1
https://pubmed.ncbi.nlm.nih.gov/29674424

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15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

Autor: Ajay Kumar, Otto Muzik, William R. Leonard, James G. Granneman, Thomas J. Mangner, James Janisse

Publikováno v: Journal of Nuclear Medicine. 54:523-531

Although it has been believed that brown adipose tissue (BAT) depots disappear shortly after the perinatal period in humans, PET imaging using the glucose analog 18F-FDG has shown unequivocally the existence of functional BAT in adult humans, suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a259a0470a6f64f21541bb92b8aa64
https://doi.org/10.2967/jnumed.112.111336

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