Výsledky vyhledávání - "Thomas J. M. Michiels"

Akademický článek

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Autor: Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz

Publikováno v: Vaccines, Vol 8, Iss 4, p 712 (2020)

Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations

Externí odkaz: https://doaj.org/article/6f84b0f9ce2b4132853060a14e99cd7c

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Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid

Autor: Hugo D. Meiring, Madelief A van Veen, Gideon F.A. Kersten, Wim Jiskoot, Bernard Metz, Thomas J M Michiels

Publikováno v: Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, 32(6), 1490-1497

Currently, animal tests are being used to confirm the potency and lack of toxicity of toxoid vaccines. In a consistency approach, animal tests could be replaced if production consistency (compared to known good products) can be proven in a panel of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96a7e7c6369fa71c62efaf9d646cb2f
http://europepmc.org/articles/PMC8176455

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Novel Formaldehyde-Induced Modifications of Lysine Residue Pairs in Peptides and Proteins: Identification and Relevance to Vaccine Development

Autor: Hugo D. Meiring, Thomas J M Michiels, Christian Schöneich, Gideon F.A. Kersten, Martin R.J. Hamzink, Bernard Metz, Wim Jiskoot

Publikováno v: Molecular Pharmaceutics. 17:4375-4385

Formaldehyde-inactivated toxoid vaccines have been in use for almost a century. Despite formaldehyde's deceptively simple structure, its reactions with proteins are complex. Treatment of immunogenic proteins with aqueous formaldehyde results in heter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5ca201472bde808daab443f88ace1d
https://doi.org/10.1021/acs.molpharmaceut.0c00851

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Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S

Autor: Wim Jiskoot, Hugo D. Meiring, Bernard Metz, Thomas J M Michiels, Gideon F.A. Kersten

Publikováno v: Scientific Reports, 10(1), 11535
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Enzymatic degradation of protein antigens by endo-lysosomal proteases in antigen-presenting cells is crucial for achieving cellular immunity. Structural changes caused by vaccine production process steps, such as formaldehyde inactivation, could affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cbab4c86105ab032338d0ba458f59d
http://hdl.handle.net/1887/136374

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Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Autor: Wim Jiskoot, Wichard Tilstra, Gideon F.A. Kersten, Maarten Danial, Hugo D. Meiring, Martin R.J. Hamzink, Bernard Metz, Thomas J M Michiels, Justin W. de Ridder

Publikováno v: Vaccines
Volume 8
Issue 4
Vaccines, Vol 8, Iss 712, p 712 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f376c683e8cecd46b672200b3f35c3
https://doi.org/10.3390/vaccines8040712

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An Affinity-Based Probe for the Human Adenosine A(2A) Receptor

Autor: Daan van der Es, Laura H. Heitman, Euan Gordon, Adriaan P. IJzerman, Thomas J M Michiels, Marjolein Soethoudt, Xue Yang, Niek Dekker, Coen de Jong, Mario van der Stelt

Publikováno v: Journal of Medicinal Chemistry, 61(17), 7892-7901. AMER CHEMICAL SOC
Journal of Medicinal Chemistry

Using activity-based protein profiling (ABPP), functional proteins can be interrogated in their native environment. Despite their pharmaceutical relevance, G protein-coupled receptors (GPCRs) have been difficult to address through ABPP. In the curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f443b4052b33998d24be7efdee3854
https://hdl.handle.net/1887/67709

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An Affinity-Based Probe for the Human Adenosine A

Autor: Xue, Yang, Thomas J M, Michiels, Coen, de Jong, Marjolein, Soethoudt, Niek, Dekker, Euan, Gordon, Mario, van der Stelt, Laura H, Heitman, Daan, van der Es, Adriaan P, IJzerman

Publikováno v: Journal of medicinal chemistry. 61(17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3e37dd9c800194409981404a44975b3
https://pubmed.ncbi.nlm.nih.gov/30080404

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A covalent antagonist for the human adenosine A2A receptor

Autor: Thomas J M Michiels, Laura H. Heitman, Xue Yang, Julien Louvel, Ad P. IJzerman, Eelke B. Lenselink, Guo Dong

Publikováno v: Purinergic signalling, 13(2), 191-201
Purinergic Signalling, 13(2), 191-201. SPRINGER
Purinergic Signalling, 13(2), 191-201
Purinergic signalling

The structure of the human A2A adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a starting point for the incorporation of reactive mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313d0b8828eaed6bc6f96956526f217f
https://hdl.handle.net/1887/64259

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A covalent antagonist for the human adenosine A

Autor: Xue, Yang, Guo, Dong, Thomas J M, Michiels, Eelke B, Lenselink, Laura, Heitman, Julien, Louvel, Ad P, IJzerman

Publikováno v: Purinergic Signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cb949b42c226f9d6338cbdd6dd0b47c
https://pubmed.ncbi.nlm.nih.gov/27915383

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