Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thomas J. Lampert"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28022 (2011)
Although G-protein coupled receptors (GPCRs) are a common element in many chemosensory transduction pathways in eukaryotic cells, no GPCR or regulated G-protein activity has yet been shown in any ciliate. To study the possible role for a GPCR in the
Externí odkaz:
https://doaj.org/article/95d378cfa44f4b8786aa80071bbb1727
Autor:
Peter N. Devreotes, Thomas J. Lampert, Yu Long, Bedri Abubaker-Sharif, Marc Edwards, Huaqing Cai
Cell migration requires the coordination of an excitable signal transduction network involving Ras and PI3K pathways with cytoskeletal activity. We show that expressing activated Ras GTPase-family proteins in cells lacking PTEN or other mutations whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546f8392cbb75330586b3e92eda15d0e
https://europepmc.org/articles/PMC6048533/
https://europepmc.org/articles/PMC6048533/
Autor:
Ayende J. Watson, Marco Tarantola, Jane Borleis, Thomas J. Lampert, Marc Edwards, Peter N. Devreotes, Nadine Kamprad
Publikováno v:
Proceedings of the National Academy of Sciences. 115
We report a forward genetic screen to identify genes involved in cell adhesion and motility. Cells with mutations in these genes have increased adhesion, flattened morphology, and decreased motility. The mutants display increased cytoskeletal and sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e8a13c7df30a950eeb3c925ba88054
https://doi.org/10.1073/pnas.1809927115
https://doi.org/10.1073/pnas.1809927115
Autor:
Yu Long, Huaqing Cai, Marc Edwards, Thomas J. Lampert, Peter N. Devreotes, Bedri Abubaker-Sharif
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Directed cell migration is at the center of the pathophysiology of many diseases such as cancer. It requires the coordination of a signal transduction network and an underlying cytoskeleton. Understanding the composition of these network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626907711f8dec0904221e535ca657e2
https://doi.org/10.1073/pnas.1710480115
https://doi.org/10.1073/pnas.1710480115
Autor:
Jane Borleis, Nadine Kamprad, Marco Tarantola, Marc Edwards, Ayende J. Watson, Thomas J. Lampert, Peter N. Devreotes
Publikováno v:
Proceedings of the National Academy of Sciences. 114
The model organism Dictyostelium discoideum has greatly facilitated our understanding of the signal transduction and cytoskeletal pathways that govern cell motility. Cell–substrate adhesion is downstream of many migratory and chemotaxis signaling e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86be269ba0ebaa254114d974ad81254
https://doi.org/10.1073/pnas.1616600114
https://doi.org/10.1073/pnas.1616600114
Autor:
Thomas J. Lampert, Pablo A. Iglesias, Peter N. Devreotes, Marc Edwards, Sayak Bhattacharya, Yuchuan Miao
Although directed migration of eukaryotic cells may have evolved to escape nutrient depletion, it has been adopted for an extensive range of physiological events during development and in the adult organism. The subversion of these movements results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93648b51bbda156be34d883f0983a238
https://europepmc.org/articles/PMC5792054/
https://europepmc.org/articles/PMC5792054/
Publikováno v:
Cellular and Molecular Life Sciences. 71:3711-3747
Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated process that involves gradient sensing, motility, and polarity. Most of our understanding of chemotaxis comes from studies of cells undergoing amoeboid-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975cb98ed2d1bff33a8cab2bcaddd962
https://doi.org/10.1007/s00018-014-1638-8
https://doi.org/10.1007/s00018-014-1638-8
Publikováno v:
International Journal of Peptides
Tetrahymena thermophila are free-living, ciliated eukaryotes. Their behavioral response to stimuli is well characterized and easily observable, since cells swim toward chemoattractants and avoid chemorepellents. Chemoattractant responses involve incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace549f41efeb9da473ed2a6c01841e
https://doi.org/10.1155/2013/573716
https://doi.org/10.1155/2013/573716
Autor:
Thomas J. Lampert, Peter N. Devreotes
Publikováno v:
Biophysical Journal. 108(2)
The model organism Dictyostelium has greatly facilitated our understanding of the signal transduction and cytoskeletal pathways that govern cell motility. Cell-substrate adhesion is a target of many chemotaxis signaling events and it can be used to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f649e88bcf3f8b3cfbdbe28732f1b2a
Autor:
Todd M, Hennessey, Thomas J, Lampert
Publikováno v:
Methods in cell biology. 109
The swimming behaviors of Tetrahymena can be used in sensitive behavioral bioassays for estimating the effects of drugs, mutations, and other conditions on the physiological state of the cell. These assays can be used in both forward and reverse gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b14d15114d6640a37bc2cab34a8184e7
https://pubmed.ncbi.nlm.nih.gov/22444154
https://pubmed.ncbi.nlm.nih.gov/22444154