Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Thomas J. Jurkiw"'
Autor:
Percy P. Tumbale, Thomas J. Jurkiw, Matthew J. Schellenberg, Amanda A. Riccio, Patrick J O’Brien, R. Scott Williams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. Here the authors present X-ray structures and kinetic analyses of LIG1 complexes with undamaged and oxidatively damaged DNA that unvei
Externí odkaz:
https://doaj.org/article/62d68ef04b744353b518a4b33195cafd
Autor:
Matthew J. Schellenberg, R. Scott Williams, Patrick J. O’Brien, Charlotte Cunningham-Rundles, Thomas J. Jurkiw, Percy P. Tumbale
Publikováno v:
Nucleic Acids Res
Human DNA ligase I (LIG1) is the main replicative ligase and it also seals DNA breaks to complete DNA repair and recombination pathways. Immune compromised patients harbor hypomorphic LIG1 alleles encoding substitutions of conserved arginine residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03a6dc2308856fd853c6bace90197d3
https://europepmc.org/articles/PMC7897520/
https://europepmc.org/articles/PMC7897520/
Autor:
Paul R. Reynolds, Jean-Laurent Casanova, Mohammad S. Ehlayel, Aurélie Cobat, José L. Chávez, Erwin W. Gelfand, Patrick Maffucci, Patrick J. O’Brien, Chitra Dinakar, Lin Radigan, Charlotte Cunningham-Rundles, Bertrand Boisson, Luigi D. Notarangelo, Jordan K. Abbott, Patricia Cortes, Thomas J. Jurkiw, Austen Worth, Kerstin Felgentreff, Tawfeg Ben-Omran
Publikováno v:
Journal of Clinical Investigation. 128:5489-5504
We report the molecular, cellular, and clinical features of 5 patients from 3 kindreds with biallelic mutations in the autosomal LIG1 gene encoding DNA ligase 1. The patients exhibited hypogammaglobulinemia, lymphopenia, increased proportions of circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c62bb6b1454ad7500ee97d4d600dae
https://doi.org/10.1172/jci99629
https://doi.org/10.1172/jci99629
Publikováno v:
Biochemistry. 56(8)
DNA ligases, essential to both in vivo genome integrity and in vitro molecular biology, catalyze phosphodiester bond formation between adjacent 3'-OH and 5'-phosphorylated termini in dsDNA. This reaction requires enzyme self-adenylylation, using ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903b61ac3cc3fc15b231b08c95a0095c
https://pubmed.ncbi.nlm.nih.gov/28165732
https://pubmed.ncbi.nlm.nih.gov/28165732
Autor:
David L. Akey, Georgios Skiniotis, Craig M. Ogata, Thomas J. Jurkiw, Richard J. Kuhn, Joyce Jose, Somnath Dutta, Jamie R. Konwerski, W. Clay Brown, Janet L. Smith, James Delproposto
Publikováno v:
Science (New York, N.Y.). 343(6173)
Two-Faced Viral Protein Flaviviruses cause human diseases such as West Nile fever and dengue fever. The flavivirus nonstructural protein 1 (NS1) has multiple functions in flavivirus biology and is a target for vaccine development. Dimeric NS1 is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e043c8a916543bffdd926a9da504fa9f
https://pubmed.ncbi.nlm.nih.gov/24558152
https://pubmed.ncbi.nlm.nih.gov/24558152