Výsledky vyhledávání - "Thomas J. Hoeffel"

Oriented substituent pharmacophore PRopErtY space (OSPPREYS): a substituent-based calculation that describes combinatorial library products better than the corresponding product-based calculation

Autor: Eric J. Martin, Thomas J. Hoeffel

Publikováno v: Journal of molecular graphicsmodelling. 18(4-5)

Initial combinatorial library designs were based on 2D substituent properties. Subsequently, two important extensions were introduced to improve the approach: use of pharmacophores to introduce 3D information, and performing calculations on the enume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2190b1386bb830ae9fa9a5a4dfe4b3c
https://pubmed.ncbi.nlm.nih.gov/11143557

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NMR structure of human erythropoietin and a comparison with its receptor bound conformation

Autor: Rashid Syed, Thomas J. Hoeffel, Joan C. Egrie, Duncan M. Smith, Timothy S. Harvey, Janet Cheetham, Kenneth H. Aoki, Janice L. Stevenson

Publikováno v: Nature structural biology. 5(10)

The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05cbe16010d52eb27cb42dde05fcb67
https://pubmed.ncbi.nlm.nih.gov/9783743

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