Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Thomas J. Hannan"'
Autor:
Anne L. Rosen, Michael A. Lint, Dayne H. Voelker, Nicole M. Gilbert, Christopher P. Tomera, Jesús Santiago-Borges, Meghan A. Wallace, Thomas J. Hannan, Carey-Ann D. Burnham, Scott J. Hultgren, Andrew L. Kau
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic Escherichia coli (UPEC) causes most of these primary infections and leads to 25% becoming recurrent or c
Externí odkaz:
https://doaj.org/article/5c84f1d8c4d040709e2dde682964be86
Autor:
Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren
Publikováno v:
EBioMedicine, Vol 1, Iss 1, Pp 46-57 (2014)
The spread of multidrug-resistant microorganisms globally has created an urgent need for novel therapeutic strategies to combat urinary tract infections (UTIs). Immunomodulatory therapy may provide benefit, as treatment of mice with dexamethasone dur
Externí odkaz:
https://doaj.org/article/06a88a77574746e8a4a2cabcd13ca808
Autor:
Lee W. Goneau, Thomas J. Hannan, Roderick A. MacPhee, Drew J. Schwartz, Jean M. Macklaim, Gregory B. Gloor, Hassan Razvi, Gregor Reid, Scott J. Hultgren, Jeremy P. Burton
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT The capacity of subinhibitory levels of antibiotics to modulate bacterial virulence in vitro has recently been brought to light, raising concerns over the appropriateness of low-dose therapies, including antibiotic prophylaxis for recurrent
Externí odkaz:
https://doaj.org/article/71cdc9b505b747b28355f83dc166f593
Autor:
Lu Yu, Valerie P O'Brien, Jonathan Livny, Denise Dorsey, Nirmalya Bandyopadhyay, Marco Colonna, Michael G Caparon, Elisha DO Roberson, Scott J Hultgren, Thomas J Hannan
Publikováno v:
eLife, Vol 8 (2019)
A mucosal infectious disease episode can render the host either more or less susceptible to recurrent infection, but the specific mechanisms that tip the balance remain unclear. We investigated this question in a mouse model of recurrent urinary trac
Externí odkaz:
https://doaj.org/article/b0c8e96f899e42328c14402806c5bb7b
Autor:
Colin J. Worby, Henry L. Schreiber, Timothy J. Straub, Lucas R. van Dijk, Ryan A. Bronson, Benjamin S. Olson, Jerome S. Pinkner, Chloe L. P. Obernuefemann, Vanessa L. Muñoz, Alexandra E. Paharik, Philippe N. Azimzadeh, Bruce J. Walker, Christopher A. Desjardins, Wen-Chi Chou, Karla Bergeron, Sinéad B. Chapman, Aleksandra Klim, Abigail L. Manson, Thomas J. Hannan, Thomas M. Hooton, Andrew L. Kau, H. Henry Lai, Karen W. Dodson, Scott J. Hultgren, Ashlee M. Earl
Publikováno v:
Nature Microbiology. 7:630-639
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d5ca8ef67bcf11c4e13ee2d5ffd68f
https://doi.org/10.1038/s41564-022-01107-x
https://doi.org/10.1038/s41564-022-01107-x
Autor:
Alexandra E. Paharik, Karla Bergeron, Thomas J. Hannan, Timothy J. Straub, Ashlee M. Earl, Scott J. Hultgren, Wen-Chi Chou, Henry L. Schreiber, Andrew L. Kau, Christopher A. Desjardins, Abigail L. Manson, Ryan A. Bronson, Lucas R. van Dijk, Karen W. Dodson, Aleksandra Klim, Sinéad B. Chapman, Vanessa L. Muñoz, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Colin J. Worby, Bruce J. Walker, H. Henry Lai, Benjamin Olson, Thomas M. Hooton
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c2ec320be5191412a9b591cb5e5f7f
https://doi.org/10.1101/2021.11.15.21266268
https://doi.org/10.1101/2021.11.15.21266268
Autor:
Shady Estfanous, Jonathan Livny, Amal O. Amer, Ting Wang, Marco Colonna, Scott J. Hultgren, Seongmi Russell, Thomas J. Hannan, Lu Yu, Valerie P. O’Brien, Thaddeus S. Stappenbeck, Hyung Joo Lee, Elisha D.O. Roberson, Benjamin Olson
Recurrent bacterial infections are a major health burden worldwide, yet the mechanisms dictating host susceptibility to recurrence are poorly understood. Here we demonstrate that an initial bacterial infection of the urinary bladder with uropathogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed43c59c7d480adc92b89c0b33f7e3a7
https://doi.org/10.21203/rs.3.rs-842556/v1
https://doi.org/10.21203/rs.3.rs-842556/v1
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004599 (2015)
Urinary tract infections (UTIs) afflict over 9 million women in America every year, often necessitating long-term prophylactic antibiotics. One risk factor for UTI is frequent sexual intercourse, which dramatically increases the risk of UTI. The mech
Externí odkaz:
https://doaj.org/article/8342e70046c04952b2ac317057909587
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001042 (2010)
Chronic infections are an increasing problem due to the aging population and the increase in antibiotic resistant organisms. Therefore, understanding the host-pathogen interactions that result in chronic infection is of great importance. Here, we inv
Externí odkaz:
https://doaj.org/article/62c16bc114f34ac589de385d922ec0ea
Publikováno v:
Expert Opinion on Drug Discovery. 12:711-731
The bacterial adhesin FimH is a virulence factor and an attractive therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type 1 pili of uropathogenic E. coli (UPEC), the FimH adhesin plays an integral role in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbac79549c3a2bd8a388e4c97a01c49
https://doi.org/10.1080/17460441.2017.1331216
https://doi.org/10.1080/17460441.2017.1331216