Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Thomas J. Diefenbach"'
Autor:
Naoki Kaneko, Hu Chen, Cory A. Perugino, Takashi Maehara, Ryusuke Munemura, Shiho Yokomizo, Junsei Sameshima, Thomas J. Diefenbach, Katherine R. Premo, Akira Chinju, Yuka Miyahara, Mizuki Sakamoto, Masafumi Moriyama, John H. Stone, Seiji Nakamura, Shiv Pillai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis is poorly understood and that lacks effective therapies. Detailed quantitative and spatial analyses of tissues affected by Sjögren’s syndrome were undertaken, inclu
Externí odkaz:
https://doaj.org/article/6813e2fa2bbf4c22b51356c495070222
Autor:
Abigail E. Schiff, Alice H. Linder, Shillah N. Luhembo, Stephanie Banning, Martin J. Deymier, Thomas J. Diefenbach, Amy K. Dickey, Athe M. Tsibris, Alejandro B. Balazs, Josalyn L. Cho, Benjamin D. Medoff, Gerhard Walzl, Robert J. Wilkinson, Wendy A. Burgers, Björn Corleis, Douglas S. Kwon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Alveolar macrophages (AMs) are critical for defense against airborne pathogens and AM dysfunction is thought to contribute to the increased burden of pulmonary infections observed in individuals living with HIV-1 (HIV). While HIV nucleic aci
Externí odkaz:
https://doaj.org/article/0c180a3a227b47598d0db0a78f5b3e8a
Autor:
David R. Collins, Julia Hitschfel, Jonathan M. Urbach, Geetha H. Mylvaganam, Ngoc L. Ly, Umar Arshad, Zachary J. Racenet, Adrienne G. Yanez, Thomas J. Diefenbach, Bruce D. Walker
Publikováno v:
Science Immunology. 8
Follicular CD8 + T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers against lymphotropic infections and cancers, but the precise mechanisms by which these cells mediate immune control remain incompletely resolved. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24786fe050f8432912dc35214ab5c98f
https://doi.org/10.1126/sciimmunol.ade5872
https://doi.org/10.1126/sciimmunol.ade5872
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
This file contains Supplementary Figure 1. Supplementary Figure 1 shows the staining pattern of tumoral PD-L1 staining.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd0c4d805e8ea8412fca3768cb7cf68
https://doi.org/10.1158/0008-5472.22414184.v1
https://doi.org/10.1158/0008-5472.22414184.v1
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
This file contains Supplementary Figure 2. Supplementary Figure 2 shows tumoral PD-L1 staining in association with PD-1, CD8, and CD4 TILs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44728a672f7d8debc0e53ba3a72bee19
https://doi.org/10.1158/0008-5472.22414181.v1
https://doi.org/10.1158/0008-5472.22414181.v1
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
This file contains Supplementary Figures 3-9. Supplementary Figure 3. Representative multi-color immunofluorescence staining shows that PD-1+CD4+ T cells demonstrate greater PD-1 expression than PD1+CD8+ T cells. Supplementary Figure 4. Representativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fb93b9ec738e6719c7d8ffd4484fab
https://doi.org/10.1158/0008-5472.22414172
https://doi.org/10.1158/0008-5472.22414172
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
This file contains Supplementary Table 1. Supplementary Table 1 shows the immunohistochemical staining for PD-L1, PD-1, CD4, and CD8 in the samples analyzed in the manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1d1ac6d8cea43466b87a952dbda2c4
https://doi.org/10.1158/0008-5472.22414169.v1
https://doi.org/10.1158/0008-5472.22414169.v1
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
This file contains Supplementary Table 2. Supplementary Table 2 shows that the proliferative capacity of PD-1 expressing CD8, CD4, and FoxP3+ TILs are decreased compared to non-PD-1 expressing TILs in OTSCC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcbba9c3692117af376c435db5ff81a
https://doi.org/10.1158/0008-5472.22414166
https://doi.org/10.1158/0008-5472.22414166
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
This file contains the figure legends for supplementary figures 1-9. Supplementary Figure 1. Staining pattern of tumoral PD-L1 staining. Supplementary Figure 2. Tumoral PD-L1 staining in association with PD-1, CD8, and CD4 TILs. Supplementary Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44411b3744c2c7a9bddd6e9c403803ca
https://doi.org/10.1158/0008-5472.22414178.v1
https://doi.org/10.1158/0008-5472.22414178.v1
Autor:
Sara I. Pai, Neil M. Iyengar, Mark C. Poznansky, Huabiao Chen, Yang C. Zeng, Lauren Johnson, Patrick D. Chakravarty, Eiichi Ishida, Armida Lefranc-Torres, Lori J. Wirth, Derrick T. Lin, Luc G. Morris, Thomas J. Diefenbach, William C. Faquin, Ronald Ghossein, Robert H. Pierce, William H. Westra, Jina Lee, Austin K. Mattox
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined the basis for the activity of programmed cell death protein (PD-1)-based immune checkpoint therapy that is being explored widely in head and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ead1b923750aef381109cb47ee27b89
https://doi.org/10.1158/0008-5472.c.6508904.v1
https://doi.org/10.1158/0008-5472.c.6508904.v1