Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Thomas J. Daly"'
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223899 (2019)
Post-translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) are important product quality attributes (PQAs) that can potentially impact drug stability, safety, and efficacy. The PTMs of a mAb may change remarkably in the blood
Externí odkaz:
https://doaj.org/article/bc935669684443b8831af144eecc7e51
Publikováno v:
Analytical Chemistry. 92:3751-3757
Host cell proteins (HCPs) are process-related impurities that are generated by the host organism and are typically present at low levels in recombinant biopharmaceutical products, such as therapeutic antibodies. While overall HCP levels are usually m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff79f299f66d543336f3f931852f4848
https://doi.org/10.1021/acs.analchem.9b05081
https://doi.org/10.1021/acs.analchem.9b05081
Autor:
May E, Montasser, Cristopher V, Van Hout, Lawrence, Miloscio, Alicia D, Howard, Avraham, Rosenberg, Myrasol, Callaway, Biao, Shen, Ning, Li, Adam E, Locke, Niek, Verweij, Tanima, De, Manuel A, Ferreira, Luca A, Lotta, Aris, Baras, Thomas J, Daly, Suzanne A, Hartford, Wei, Lin, Yuan, Mao, Bin, Ye, Derek, White, Guochun, Gong, James A, Perry, Kathleen A, Ryan, Qing, Fang, Gannie, Tzoneva, Evangelos, Pefanis, Charleen, Hunt, Yajun, Tang, Lynn, Lee, Carole, Sztalryd-Woodle, Braxton D, Mitchell, Matthew, Healy, Elizabeth A, Streeten, Simeon I, Taylor, Jeffrey R, O'Connell, Aris N, Economides, Giusy, Della Gatta, Alan R, Shuldiner
Publikováno v:
Science (New York, N.Y.). 374(6572)
Increased blood levels of low-density lipoprotein cholesterol (LDL-C) and fibrinogen are independent risk factors for cardiovascular disease. We identified associations between an Amish-enriched missense variant (p.Asn352Ser) in a functional domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b73b02316e34823aaf3cad8f3182e065
https://pubmed.ncbi.nlm.nih.gov/34855475
https://pubmed.ncbi.nlm.nih.gov/34855475
Publikováno v:
Analytical Chemistry. 91:11417-11424
Detection and quantitation of homodimer impurities in therapeutic bispecific antibody (bsAb) drug products is essential to support development and quality control (QC) release. LC-MS-based techniques have been frequently applied for this analysis. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fc9e21defc3a15419ff180477e9cec
https://doi.org/10.1021/acs.analchem.9b02793
https://doi.org/10.1021/acs.analchem.9b02793
Publikováno v:
mAbs
Growth in the pharmaceutical industry has led to an increasing demand for rapid characterization of therapeutic monoclonal antibodies. The current methods for antibody sequence confirmation (e.g., N-terminal Edman sequencing and traditional peptide m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c1fb004ec0a2120207056018e607c2
https://doi.org/10.1080/19420862.2019.1599633
https://doi.org/10.1080/19420862.2019.1599633
Autor:
Thomas DiCioccio, Nicholas J. Papadopoulos, Albert Torri, Thomas J. Daly, Giane Sumner, Camille Georgaros, Joel H. Martin, Ashique Rafique
Publikováno v:
Bioanalysis. 11:381-392
Aim: To evaluate the accuracy of the Quantikine Human VEGF Immunoassay (R&D Systems) in the presence of VEGF inhibitors. Materials & Methods: Quantikine VEGF ELISA (R&D), anti-VEGF165 mAb (R&D), VEGF165 and aflibercept (Regeneron), ranibizumab and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222f287dc262a8281e03fafa9f263179
https://doi.org/10.4155/bio-2018-0096
https://doi.org/10.4155/bio-2018-0096
Autor:
Simeon I. Taylor, Rebecca McFarland, James A. Perry, Thomas J. Daly, Lawrence Miloscio, Norann A. Zaghloul, Carole Sztalryd-Woodle, Alicia D. Howard, Nhlbi TOPMed Program, Rosenberg Avraham Z, Elizabeth A. Streeten, Braxton D. Mitchell, Wei Lin, Jeffrey R. O'Connell, Ning Li, Myrasol Callaway, Giusy Della Gatta, Biao Shen, Bin Ye, May E. Montasser, Alan R. Shuldiner, Kathleen A. Ryan, Gannie Tzoneva, Cristopher V. Van Hout, Matthew Healy, Yuan Mao, Aris N. Economides
Increased LDL-cholesterol (LDL-C) and fibrinogen are independent risk factors for cardiovascular disease (CVD). We identified novel associations between an Amish-enriched missense variant (p.Asn352Ser) in a functional domain of beta-1,4-galactosyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187acb93db33685591bee35472812bea
https://doi.org/10.1101/721704
https://doi.org/10.1101/721704
Publikováno v:
Analytical chemistry. 91(4)
LC-MS based analysis of protein biopharmaceuticals could benefit from improved data quality, which can subsequently lead to improved drug characterization with higher confidence and less ambiguity. In this study, we created a simple device to modify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a138d4ef5139b40a629da005bc30e4
https://pubmed.ncbi.nlm.nih.gov/30682238
https://pubmed.ncbi.nlm.nih.gov/30682238
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 186:113313
Native mass spectrometry (native MS) has seen tremendous development and an increase in application over the past decade for the study of proteins and protein complexes. Although conventionally performed using a static nanospray emitter in an offline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c95de3ccd311c899fc13453bed75f5
https://doi.org/10.1016/j.jpba.2020.113313
https://doi.org/10.1016/j.jpba.2020.113313
Publikováno v:
Analytical chemistry. 90(21)
In therapeutic monoclonal antibody (mAb) development, charge heterogeneity of a mAb molecule is often associated with critical quality attributes and is therefore monitored throughout development and during QC release to ensure product and process co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0757936212e0cddde1a6b7a3e1cbace1
https://pubmed.ncbi.nlm.nih.gov/30280893
https://pubmed.ncbi.nlm.nih.gov/30280893