Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Thomas J. Colatsky"'
Autor:
Vladislav V. Nesterenko, Charles Antzelevitch, Adam L. Muzikant, Thomas J. Colatsky, John Jeremy Rice, Gang Chen
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences. 359:1201-1216
Ventricular myocardium comprises at least three electrophysiologically distinct cell types: epicardial, endocardial and M cells. Epicardial and M cells, but not endocardial cells, display action potentials with a notched or spike–and–dome morphol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb123681508d23e1e3914e1bf6cd336b
https://doi.org/10.1098/rsta.2001.0826
https://doi.org/10.1098/rsta.2001.0826
Autor:
Thomas J Colatsky, Denis Noble
Publikováno v:
Emerging Therapeutic Targets. 4:39-49
Identifying drug targets successfully requires that we understand the functional interactions between the key components of cells, organs and systems, and how these interactions change in disease states. This information does not reside in the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1668c8f887a94daf2a18f938b5695bc6
https://doi.org/10.1517/14728222.4.1.39
https://doi.org/10.1517/14728222.4.1.39
Autor:
DeGennaro Lj, Askew Gr, Jow B, Kulik J, Thomas M. Argentieri, Nieuwenhuijsen B, Bridal Tr, Walter Spinelli, Su Cm, Thomas J. Colatsky, Babij P
Publikováno v:
Circulation Research. 83:668-678
Abstract —Mutations in the HERG gene are linked to the LQT2 form of the inherited long-QT syndrome. Transgenic mice were generated expressing high myocardial levels of a particularly severe form of LQT2-associated HERG mutation (G628S). Hearts from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42dfd4e18b74cb497072bc35ff9fc7a
https://doi.org/10.1161/01.res.83.6.668
https://doi.org/10.1161/01.res.83.6.668
Publikováno v:
Neuron. 16(5):913-919
The vast array of medical conditions potentially amenable to treatment by drugs that act on ion channels makes the pursuit of these investigations attractive and compelling. However, the best route to designing safe and effective agents remains uncer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59edcbf1a9f83d4c32eb8186209a82c
Publikováno v:
Drug Development Research. 33:235-249
Selective prolongation of cardiac repolarization is an effective means of suppressing a variety of cardiac arrhythmias, particularly those arising from a re-entrant mechanism. Over the past several years, a variety of novel compounds have been discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89e887d541a5a8f64317d3bcae4b4463
https://doi.org/10.1002/ddr.430330307
https://doi.org/10.1002/ddr.430330307
Autor:
N. Halaka, Thomas M. Argentieri, D. Zebick, C. Havens, N J Lodge, Richard M. Soll, Thomas J. Colatsky, Paul Jeffrey Dollings, R.J. McCaully, George Oshiro, N.W. Norton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:769-773
N-sulfonamides of the benzopyran-related class of potassium channel openers were found to inhibit KCl-induced contractions of smooth muscle preparations (rat aorta or bladder preparations) in a glyburide insensitive manner or to augment contractions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a684e6f0724049254fe827bd7a0edd69
https://doi.org/10.1016/s0960-894x(01)80198-0
https://doi.org/10.1016/s0960-894x(01)80198-0
Publikováno v:
Cardiovascular Research. 27:1580-1591
Objective: The objectives were (a) to evaluate the effects of WAY-123,398, a new class III antiarrhythmic agent, on the action potential of canine Purkinje fibres in comparison with dofetilide, E-4031, and dl-sotalol, and (b) to characterise the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fde3334722a822f8dab325150cbcb85
https://doi.org/10.1093/cvr/27.9.1580
https://doi.org/10.1093/cvr/27.9.1580
Autor:
D. Hartupee, John D. McCallum, V. White, William A. Kinney, A. Russo, R.J. McCaully, J. Dinish, George Oshiro, Richard M. Soll, C.H. Park, John Primeau, A. Wojdan, L. Garrick, Thomas J. Colatsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:757-760
Application of the novel carboxylic acid bioisostere 3-hydroxy-3-cyclobutene-1,2-dione to the design of a potent, non-peptidic, non-tetrazole angiotensin II antagonist 4 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb88c19ba1545d818804340dcc334f4d
https://doi.org/10.1016/s0960-894x(01)81269-5
https://doi.org/10.1016/s0960-894x(01)81269-5
Autor:
Thomas J, Colatsky
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 11(3)
The goal of biomarker research in drug development is to identify better ways of monitoring the effects of drugs on biological systems. Biomarker data are used to support decision making at various stages in the drug development process, and are also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88bc4d2dda71779928d76fcd09625e2f
https://pubmed.ncbi.nlm.nih.gov/20178038
https://pubmed.ncbi.nlm.nih.gov/20178038
Publikováno v:
Cardiovascular Research. 26:1121-1130
Objective: The aim was to compare the effects of the class Ic antiarrhythmic drugs flecainide, encainide, and recainam on the delayed rectifier current, IK. Methods: Membrane currents were studied using the single suction pipette voltage clamp techni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ede37e1bf8b5232715e97245d4d4a3
https://doi.org/10.1093/cvr/26.11.1121
https://doi.org/10.1093/cvr/26.11.1121