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pro vyhledávání: '"Thomas J. Carew"'
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Two-trial learning in Aplysia reveals nonlinear interactions between training trials: A single trial has no effect, but two precisely spaced trials induce long-term memory. Extracellularly regulated kinase (ERK) activity is essential for intertrial i
Autor:
Thomas J. Carew
Publikováno v:
J Neurosci
Some of us fortunate enough to have published a paper in The Journal of Neuroscience in its inaugural year (1981) have been asked to write a Progressions article addressing our views on the significance of the original work and how ideas about the to
Publikováno v:
J Neurosci
Long-term memory (LTM) formation is a critical survival process by which an animal retains information about prior experiences to guide future behavior. In the experimentally advantageous marine molluskAplysia, LTM for sensitization can be induced by
Autor:
Mani Ramaswami, Thomas J. Carew
Publikováno v:
Neuron. 108:590-593
Neuroscience has an extraordinary opportunity to investigate issues historically addressed by the arts, humanities, and social sciences. As a guide, we suggest three features of meaningful progress in the collaborative field, the neurohumanities, whi
Autor:
Anamaria Alexandrescu, Thomas J. Carew
Publikováno v:
Learn Mem
The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of Aplysia cysteine-rich neurotrophic fac
Long-term memory (LTM) formation is a critical survival process by which an animal retains information about prior experiences in order to guide future behavior. In the experimentally advantageous marine mollusk Aplysia, LTM for sensitization can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ed311f8d7ea2f35a863ceb4664f69d4
https://doi.org/10.1101/2020.08.14.251389
https://doi.org/10.1101/2020.08.14.251389
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Insulin-like growth factor II (IGF2) enhances memory in rodents via the mannose-6-phosphate receptor (M6PR), but the underlying mechanisms remain poorly understood. We found that human IGF2 produces an enhancement of both synaptic transmission and ne
Autor:
Thomas J. Carew, Anastasios A. Mirisis
Publikováno v:
Neurobiol Learn Mem
The mechanisms of de novo gene expression and translation of specific gene transcripts have long been known to support long-lasting changes in synaptic plasticity and behavioral long-term memory. In recent years, it has become increasingly apparent t
Publikováno v:
Learning & Memory. 23:182-188
In this study, we explore the mechanistic relationship between growth factor signaling and kinase activity that supports the protein synthesis-dependent phase of long-term memory (LTM) consolidation for sensitization of Aplysia. Specifically, we exam
Publikováno v:
AIMS neuroscience
The ability to form long-lasting memories is critical to survival and thus is highly conserved across the animal kingdom. By virtue of its complexity, this same ability is vulnerable to disruption by a wide variety of neuronal traumas and pathologies