Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Thomas J. Begley"'
Autor:
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Publikováno v:
Epigenetics, Vol 15, Iss 10, Pp 1121-1138 (2020)
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alk
Externí odkaz:
https://doaj.org/article/d464ab1c8bef4c1bb173527d6328c626
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and
Externí odkaz:
https://doaj.org/article/a293763e26db4303bfaea6bace763753
Autor:
Shruti Nagaraja, Maggi W. Cai, Jingjing Sun, Hugo Varet, Lotem Sarid, Meirav Trebicz-Geffen, Yana Shaulov, Mohit Mazumdar, Rachel Legendre, Jean-Yves Coppée, Thomas J. Begley, Peter C. Dedon, Samudrala Gourinath, Nancy Guillen, Yumiko Saito-Nakano, Chikako Shimokawa, Hajime Hisaeda, Serge Ankri
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT Queuosine is a naturally occurring modified ribonucleoside found in the first position of the anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to synthesize queuine, the nucleobase precursor to queuosine, a
Externí odkaz:
https://doaj.org/article/497ef5cb0f7e4ff8a51086e7aee30122
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Critically important to the maintenance of the glutathione (GSH) redox cycle are the activities of many selenocysteine-containing GSH metabolizing enzymes whose translation is controlled by the epitranscriptomic writer alkylation repair homolog 8 (AL
Externí odkaz:
https://doaj.org/article/82092cb9d7954b5697f7e9f87c9ba9c2
Autor:
Daniel A. Rothenberg, J. Matthew Taliaferro, Sabrina M. Huber, Thomas J. Begley, Peter C. Dedon, Forest M. White
Publikováno v:
iScience, Vol 9, Iss , Pp 367-381 (2018)
Summary: To quantify dynamic protein synthesis rates, we developed MITNCAT, a method combining multiplexed isobaric mass tagging with pulsed SILAC (pSILAC) and bio-orthogonal non-canonical amino acid tagging (BONCAT) to label newly synthesized protei
Externí odkaz:
https://doaj.org/article/944a04c5a2954b2c94e120526e239a86
Autor:
Yok Hian Chionh, Megan McBee, I. Ramesh Babu, Fabian Hia, Wenwei Lin, Wei Zhao, Jianshu Cao, Agnieszka Dziergowska, Andrzej Malkiewicz, Thomas J. Begley, Sylvie Alonso, Peter C. Dedon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use
Externí odkaz:
https://doaj.org/article/ef49a7068372488eae9591272d451d23
Autor:
Leticia Pollo-Oliveira, Roland Klassen, Nick Davis, Akif Ciftci, Jo Marie Bacusmo, Maria Martinelli, Michael S. DeMott, Thomas J. Begley, Peter C. Dedon, Raffael Schaffrath, Valérie de Crécy-Lagard
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 322 (2020)
Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t6A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm5s2U34) are critical ASL modificatio
Externí odkaz:
https://doaj.org/article/90c9417bfa2d491abf840ab456cc3ab7
Publikováno v:
Toxics, Vol 7, Iss 1, p 17 (2019)
Living organisms respond to environmental changes and xenobiotic exposures by regulating gene expression. While heat shock, unfolded protein, and DNA damage stress responses are well-studied at the levels of the transcriptome and proteome, tRNA-media
Externí odkaz:
https://doaj.org/article/8e313cdad0a3457b89ee77cb6df667ae
Publikováno v:
Biomolecules, Vol 7, Iss 3, p 65 (2017)
There are over 100 enzyme-catalyzed modifications on transfer RNA (tRNA) molecules. The levels and identity of wobble uridine (U) modifications are affected by environmental conditions and diseased states, making wobble U detection a potential biomar
Externí odkaz:
https://doaj.org/article/b06a4b3340dc4cee9a3864017c97a8a4
Autor:
Clement T. Y. Chan, Madhu Dyavaiah, Michael S. DeMott, Koli Taghizadeh, Peter C. Dedon, Thomas J. Begley
Publikováno v:
PLoS Genetics, Vol 7, Iss 2 (2011)
Externí odkaz:
https://doaj.org/article/f7322e4e96e8428390b73fee6b6c0610