Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thomas J Utley"'
Autor:
Fyza Y Shaikh, Thomas J Utley, Ryan E Craven, Meredith C Rogers, Lynne A Lapierre, James R Goldenring, James E Crowe
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40826 (2012)
Respiratory syncytial virus (RSV) is a single-stranded RNA virus that assembles into viral filaments at the cell surface. Virus assembly often depends on the ability of a virus to use host proteins to accomplish viral tasks. Since the fusion protein
Externí odkaz:
https://doaj.org/article/974d60faea5648759a990536d9eda991
Autor:
Zixiu Xiang, Corey R. Hopkins, Craig W. Lindsley, Michael R. Wood, Emily Days, Sean R. Bollinger, Karen J. Gregory, Francine Acher, L. Michelle Lewis, Darren W. Engers, P. Jeffrey Conn, Julie R. Field, Colleen M. Niswender, Margrith E. Mattmann, Bruce J. Melancon, C. David Weaver, Adam G. Walker, Rocio Zamorano, Rebecca Klar, Miguel A. Hurtado, Nidhi Jalan-Sakrikar, Thomas J. Utley, Delphine Rigault
Publikováno v:
ACS Chemical Neuroscience
Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53054405fa5493f60e9af66a15e0439b
https://doi.org/10.1021/cn500153z
https://doi.org/10.1021/cn500153z
Autor:
Carrie K. Jones, Colleen M. Niswender, Bruce J. Melancon, Thomas M. Bridges, Uyen M. Le, Daryl F. Venable, Douglas J. Sheffler, J. Scott Daniels, Craig W. Lindsley, Atin Lamsal, Paige N. Vinson, Corey R. Hopkins, Alice L. Rodriguez, Thomas J. Utley, P. Jeffrey Conn, Michael R. Wood, Anna L. Blobaum
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:346-350
Herein we report a next generation muscarinic receptor 4 (M(4)) positive allosteric modulator (PAM), ML253 which exhibits nanomolar activity at both the human (EC(50)=56 nM) and rat (EC(50)=176 nM) receptors and excellent efficacy by the left-ward sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090a4193bd9073a7f450747e03798959
https://doi.org/10.1016/j.bmcl.2012.10.073
https://doi.org/10.1016/j.bmcl.2012.10.073
Autor:
Colleen M. Niswender, Michael R. Wood, P.J. Conn, Christian Sevel, Ryan D. Morrison, Craig W. Lindsley, Thomas M. Bridges, Thomas J. Utley, Douglas J. Sheffler, Nathan R. Kett, J. S. Daniels, Michael S. Poslusney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6923-6928
Utilizing a combination of high-throughput and multi-step synthesis, SAR in a novel series of M1 acetylcholine receptor antagonists was rapidly established. The efforts led to the discovery the highly potent M1 antagonists 6 (VU0431263), and 8f (VU04
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb5cea6985279f87de6884870073fab
https://doi.org/10.1016/j.bmcl.2012.09.011
https://doi.org/10.1016/j.bmcl.2012.09.011
Autor:
Gregory J. Digby, Michael R. Wood, P. Jeffrey Conn, Douglas J. Sheffler, Craig W. Lindsley, Evan P. Lebois, Colleen M. Niswender, Atin Lamsal, Christian Sevel, Thomas M. Bridges, Thomas J. Utley
Publikováno v:
ACS Chemical Neuroscience. 3:1025-1036
We previously reported the discovery of VU0364572 and VU0357017 as M(1)-selective agonists that appear to activate M(1) through actions at an allosteric site. Previous studies have revealed that chemical scaffolds for many allosteric modulators conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e865be5e6b7fd4d14f9f5503f9c135e
https://doi.org/10.1021/cn300103e
https://doi.org/10.1021/cn300103e
Autor:
Douglas J. Sheffler, Ryan D. Morrison, Michael R. Wood, Colleen M. Niswender, Gary A. Sulikowski, Meredith J. Noetzel, Bruce J. Melancon, P. Jeffrey Conn, Thomas J. Utley, Thomas M. Bridges, Craig W. Lindsley, J. Scott Daniels, Alexander P. Lamers, Carrie K. Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1044-1048
This Letter describes the continued optimization of an MLPCN probe molecule (ML012) through an iterative parallel synthesis approach. After exploring extensive modifications throughout the parent structure, we arrived at a more highly M(1)-selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0270037b1714f96053eb2fcbd3a3d96f
https://doi.org/10.1016/j.bmcl.2011.11.110
https://doi.org/10.1016/j.bmcl.2011.11.110
Autor:
Aaron W. Lifland, Philip J. Santangelo, Thomas J. Utley, Michael E. Lindquist, James E. Crowe
Publikováno v:
Journal of Virology
Mammalian cell cytoplasmic RNA stress granules are induced during various conditions of stress and are strongly associated with regulation of host mRNA translation. Several viruses induce stress granules during the course of infection, but the exact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f421fa9fdbc51555b228bf1ccd0283
https://doi.org/10.1128/jvi.00260-10
https://doi.org/10.1128/jvi.00260-10
Autor:
Emery Smith, Craig W. Lindsley, Colleen M. Niswender, Mary Acosta, Michael R. Wood, Douglas J. Sheffler, Louis Scampavia, Thomas J. Utley, Peter Chase, P. Jeffrey Conn, Meredith J. Noetzel, Atin Lamsal, Franck Madoux, Timothy P. Spicer, Peter Hodder
Muscarinic acetylcholine receptors (mAChRs) have long been viewed as viable targets for novel therapeutic agents for the treatment of Alzheimer's disease and other disorders involving impaired cognitive function. In an attempt to identify orthosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58167b6c98dec5b4d0a7b8ffb602f17d
https://europepmc.org/articles/PMC4659430/
https://europepmc.org/articles/PMC4659430/
Autor:
Michael R. Wood, Colleen M. Niswender, Ryan D. Morrison, Patrick R. Gentry, Craig W. Lindsley, Peter Chase, J. Scott Daniels, Thomas M. Bridges, P. Jeffrey Conn, Hyekyung P. Cho, Frank W. Byers, Peter Hodder, Thomas J. Utley, Emery Smith, Masaya Kokubo, Anuruddha Rajapakse
Publikováno v:
ChemMedChem.
Of the five G-protein-coupled muscarinic acetylcholine receptors (mAChRs; M1–M5), M5 is the least explored and understood due to a lack of mAChR subtype-selective ligands. We recently performed a high-throughput functional screen and identified a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e25965c9443ce6122b62a6c7a4f77f
https://doi.org/10.1002/cmdc.201402051
https://doi.org/10.1002/cmdc.201402051
Autor:
William R. Schief, Bruno E. Correia, Thomas J. Utley, Christopher J. Keefer, John T. Bates, James E. Crowe
Publikováno v:
The Journal of Immunology
The role of affinity in determining neutralizing potency of monoclonal antibodies directed against viruses is not well understood. We investigated the kinetic, structural, and functional advantage conferred by individual naturally-occurring somatic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade1a623c7f91b941e7b1eb1dfbe8814
https://europepmc.org/articles/PMC3608519/
https://europepmc.org/articles/PMC3608519/