Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas J Sweet"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228730 (2020)
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript
Externí odkaz:
https://doaj.org/article/9b0d297e33144ab3b3aae497350dd684
Autor:
Geneva R. LaForce, Jordan S. Farr, Jingyi Liu, Cydni Akesson, Evren Gumus, Otis Pinkard, Helen C. Miranda, Katherine Johnson, Thomas J. Sweet, Ping Ji, Ai Lin, Jeff Coller, Polyxeni Philippidou, Eric J. Wagner, Ashleigh E. Schaffer
Publikováno v:
Neuron
Tight regulation of mRNA isoform expression is essential for neuronal development, maintenance, and function; however, the repertoire of proteins that govern isoform composition and abundance remains incomplete. Here, we show that the RNA kinase CLP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446f784bc0f3feb6332d1d38d47e4a27
https://pubmed.ncbi.nlm.nih.gov/35447096
https://pubmed.ncbi.nlm.nih.gov/35447096
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Transfer RNAs (tRNA) are quintessential in deciphering the genetic code; disseminating nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an emerging theme is that tRNA abundance and functionality can power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fd82441636ea08e37c5dabe23063cb
https://doi.org/10.1038/s41467-020-17879-x
https://doi.org/10.1038/s41467-020-17879-x
Autor:
Yoshitaka Matsuo, Robert Buschauer, Andrea Gilmozzi, Toshifumi Inada, Roland Beckmann, Petr Tesina, Najwa Alhusaini, Jingdong Cheng, Jeff Coller, Risa Nobuta, Otto Berninghausen, Yasuko Matsuki, Ying Hsin Chen, Thomas J. Sweet, Thomas Becker, Ken Ikeuchi, Takato Sugiyama
Publikováno v:
Science
INTRODUCTION: The tightly controlled process of gene expression requires messenger RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated by the protein-producing machinery of the cell, the ribosomes. Therefore, prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbc9be3fc634be9d1735b77ca375e69
https://doi.org/10.1126/science.aay6912
https://doi.org/10.1126/science.aay6912
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 2, p e0228730 (2020)
PLoS ONE, Vol 15, Iss 2, p e0228730 (2020)
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4613593cdfcd9514ee371c73902d9e80
https://pubmed.ncbi.nlm.nih.gov/32053646
https://pubmed.ncbi.nlm.nih.gov/32053646
Autor:
Andrea Gilmozzi, Thomas J. Sweet, Jingdong Cheng, Robert Buschauer, Otto Berninghausen, Najwa Alhusaini, Roland Beckmann, Takato Sugiyama, Yasuko Matsuki, Toshifumi Inada, Yoshitaka Matsuo, Thomas Becker, Ken Ikeuchi, Jeff Coller, Ying Hsin Chen
Control of mRNA decay rate is intimately connected to translation elongation but the spatial coordination of these events is poorly understood. The Ccr4-Not complex initiates mRNA decay through deadenylation and activation of decapping. Using a combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5935e019f18bf5bcf0b03a52e645373b
Autor:
Daniel Arango, Shalini Oberdoerffer, Ashrut Narula, Thomas J. Sweet, James Ellis, Megan E. Forrest, Gavin Hanson, Jeff Coller, Olivia S. Rissland
mRNA degradation is a critical, yet poorly understood, aspect of gene expression. Previous studies demonstrate that codon content acts as a major determinant of mRNA stability in model organisms. In humans, the importance of open reading frame (ORF)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8380c5fbce93ef2db7dd4948b87984a
https://doi.org/10.1101/488676
https://doi.org/10.1101/488676
Autor:
Thomas J. Sweet, Byron H. Lee, Changjin Hong, Jeffrey M. Bhasin, Srinidhi Singuri, Tae Hyun Hwang, Angela H. Ting, Emily E. Fink, Vishal Nanavaty, Elizabeth W. Abrash, Sunho Park, Zhuangyue Li
Publikováno v:
Mol Cell
Dysregulation of DNA methylation and mRNA alternative cleavage and polyadenylation (APA) are both prevalent in cancer and have been studied as independent processes. We discovered a DNA methylation-regulated APA mechanism when we compared genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e13ec024d249a57940a1c36e98bf337
https://doi.org/10.1016/j.molcel.2020.03.024
https://doi.org/10.1016/j.molcel.2020.03.024
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in eukaryotic cells. Previous work by us and others has shown that codon identity exerts a powerful influence on mRNA stability. InSaccharomyces cerevisiae, studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0669dc3df0f5a4d6d032776d961fa42
https://doi.org/10.1101/300467
https://doi.org/10.1101/300467
Autor:
Raul Jobava, Leah L. Zagore, Chaolin Zhang, Molly M. Hannigan, Maria Hatzoglou, Sebastien M. Weyn-Vanhentenryck, Donny D. Licatalosi, Thomas J. Sweet
Publikováno v:
Cell reports
SUMMARY The RNA binding protein DAZL is essential for gametogenesis, but its direct in vivo functions, RNA targets, and the molecular basis for germ cell loss in Dazl-null mice are unknown. Here, we mapped transcriptome-wide DAZL-RNA interactions in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575482311c1ae449597f0f978ceff275
https://doi.org/10.1101/273292
https://doi.org/10.1101/273292