Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Thomas J Simpson"'
Publikováno v:
Phytomedicine Plus, Vol 4, Iss 2, Pp 100546- (2024)
Background: Trianthema pentandra is a promising plant with numerous medical applications. Previous studies have confirmed that the plant is strongly cytotoxic in brine shrimp lethality tests and has antibacterial effects. However, the compounds respo
Externí odkaz:
https://doaj.org/article/a250fc17ec5c4161b39fb724a966ab6e
A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.
Autor:
Daisuke Fukuda, Anthony S Haines, Zhongshu Song, Annabel C Murphy, Joanne Hothersall, Elton R Stephens, Rachel Gurney, Russell J Cox, John Crosby, Christine L Willis, Thomas J Simpson, Christopher M Thomas
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18031 (2011)
Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids of two
Externí odkaz:
https://doaj.org/article/f65d8ef4119a44789cb398feeee148db
Publikováno v:
Journal of Natural Products. 85:2236-2250
This Review provides a critical analysis of the literature covering the naturally occurring partially reduced perylenequinones (PQs) from fungi without carbon substituents (which can be named class A perylenequinones) and discusses their structures,
Autor:
Trong-Tuan Dao, Katherine Williams, Kate M. J. de Mattos-Shipley, Zhongshu Song, Yuiko Takebayashi, Thomas J. Simpson, James Spencer, Andrew M. Bailey, Christine L. Willis
Publikováno v:
Dao, T T, Williams, K, de Mattos-Shipley, K M J, Song, Z, Takebayashi, Y, Simpson, T J, Spencer, J, Bailey, A M & Willis, C L 2022, ' Cladobotric acids: Metabolites from cultures of Cladobotryum sp., semi-synthetic analogues and antibacterial activity ', Journal of Natural Products, vol. 85, no. 3, pp. 572-580 . https://doi.org/10.1021/acs.jnatprod.1c01063
Three new polyketide-derived natural products, cladobotric acids G–I (1–3), and six known metabolites (4, 5, 8–11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spect
Autor:
Kate M. J. de Mattos-Shipley, Christine L. Willis, Iman A Y Ghannam, Jonathan C Killen, James W. Marshall, Thomas J. Simpson, Asifa Munawar, Colin M. Lazarus, Russell J. Cox
Publikováno v:
Organic & Biomolecular Chemistry. 19:182-187
Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporatio
Autor:
Thomas J. Simpson, Christine L. Willis
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 70:297-312
Jake MacMillan, although by training and personal acclamation ‘first and foremost an organic chemist’, was one of the UK's most brilliant interdisciplinary scientists. A pioneer in the field of bioorganic chemistry, he was practising what we woul
Autor:
Zhongshu Song, Paul R. Race, Thomas J. Simpson, Christine L. Willis, Luoyi Wang, Matthew P. Crump, James Spencer
Publikováno v:
Chemical Science
Wang, L, Song, Z, Race, P R, Spencer, J, Simpson, T J, Crump, M P & Willis, C L 2020, ' Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics ', Chemical Science, vol. 11, pp. 5221-5226 . https://doi.org/10.1039/C9SC06192D
Wang, L, Song, Z, Race, P R, Spencer, J, Simpson, T J, Crump, M P & Willis, C L 2020, ' Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics ', Chemical Science, vol. 11, pp. 5221-5226 . https://doi.org/10.1039/C9SC06192D
With growing understanding of the underlying pathways of polyketide biosynthesis, along with the continual expansion of the synthetic biology toolkit, it is becoming possible to rationally engineer and fine-tune the polyketide biosynthetic machinery
Autor:
Jozef Anné, Eveline-Marie Lammens, Piet Herdewijn, Thomas Lathouwers, Matthew P. Crump, Michiel Vanmeert, Harry Cuppens, Joleen Masschelein, Ruben Degroote, Eveline Lescrinier, Ling-Jie Gao, Rob Lavigne, Angus N M Weir, Simone Kosol, Thomas J. Simpson, Kristof Vrancken, Christine L. Willis, Christopher D. Fage
Publikováno v:
Fage, C D, Lathouwers, T, Vanmeert, M, Gao, L-J, Vrancken, K, Lammens, E-M, Weir, A N M, Degroote, R, Cuppens, H, Kosol, S, Simpson, T J, Crump, M P, Willis, C L, Herdewijn, P, Lescrinier, E, Lavigne, R, Anné, J & Masschelein, J 2020, ' The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI ', Angewandte Chemie-International Edition, vol. 59, no. 26, pp. 10549-10556 . https://doi.org/10.1002/anie.201915407
The enoyl-acyl carrier protein reductase enzyme FabI is essential for fatty acid biosynthesis in Staphylococcus aureus and represents a promising target for the development of novel, urgently needed anti-staphylococcal agents. Here, we elucidate the
Autor:
Nahida Akter, Matthew T. Rowe, Ashley J. Winter, Christine L. Willis, Christopher Williams, Matthew P. Crump, Thomas J. Simpson, Paul R. Race, Zhongshu Song, Angus N M Weir, Luoyi Wang, Paul D. Walker
Publikováno v:
Walker, P D, Rowe, M T, Winter, A J, Weir, A N M, Akter, N, Wang, L, Race, P R, Williams, C, Song, Z, Simpson, T J, Willis, C L & Crump, M P 2020, ' A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis ', ACS Chemical Biology, vol. 2020 . https://doi.org/10.1021/acschembio.9b00969
Mupirocin, a commercially available antibiotic produced by Pseudomonas fluorescens NCIMB 10586, and thiomarinol, isolated from the marine bacterium Pseudoalteromonas sp. SANK 73390, both consist of a polyketide-derived monic acid homologue esterified
Publikováno v:
Journal of Fungi, Vol 4, Iss 3, p 96 (2018)
Aspergillus oryzae is traditionally used in East Asia for the production of food and brewing. In addition, it has been developed into a suitable host for the heterologous expression of natural product biosynthetic genes and gene clusters, enabling th
Externí odkaz:
https://doaj.org/article/abb258e8f2784694b566ccfd5f884def