Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Thomas J M Michiels"'
Autor:
Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz
Publikováno v:
Vaccines, Vol 8, Iss 4, p 712 (2020)
Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations
Externí odkaz:
https://doaj.org/article/6f84b0f9ce2b4132853060a14e99cd7c
Autor:
Hugo D. Meiring, Madelief A van Veen, Gideon F.A. Kersten, Wim Jiskoot, Bernard Metz, Thomas J M Michiels
Publikováno v:
Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, 32(6), 1490-1497
Journal of the American Society for Mass Spectrometry, 32(6), 1490-1497
Currently, animal tests are being used to confirm the potency and lack of toxicity of toxoid vaccines. In a consistency approach, animal tests could be replaced if production consistency (compared to known good products) can be proven in a panel of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96a7e7c6369fa71c62efaf9d646cb2f
http://europepmc.org/articles/PMC8176455
http://europepmc.org/articles/PMC8176455
Autor:
Hugo D. Meiring, Thomas J M Michiels, Christian Schöneich, Gideon F.A. Kersten, Martin R.J. Hamzink, Bernard Metz, Wim Jiskoot
Publikováno v:
Molecular Pharmaceutics. 17:4375-4385
Formaldehyde-inactivated toxoid vaccines have been in use for almost a century. Despite formaldehyde's deceptively simple structure, its reactions with proteins are complex. Treatment of immunogenic proteins with aqueous formaldehyde results in heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5ca201472bde808daab443f88ace1d
https://doi.org/10.1021/acs.molpharmaceut.0c00851
https://doi.org/10.1021/acs.molpharmaceut.0c00851
Autor:
Wim Jiskoot, Wichard Tilstra, Gideon F.A. Kersten, Maarten Danial, Hugo D. Meiring, Martin R.J. Hamzink, Bernard Metz, Thomas J M Michiels, Justin W. de Ridder
Publikováno v:
Vaccines
Volume 8
Issue 4
Vaccines, Vol 8, Iss 712, p 712 (2020)
Volume 8
Issue 4
Vaccines, Vol 8, Iss 712, p 712 (2020)
Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f376c683e8cecd46b672200b3f35c3
https://doi.org/10.3390/vaccines8040712
https://doi.org/10.3390/vaccines8040712
Autor:
Daan van der Es, Laura H. Heitman, Euan Gordon, Adriaan P. IJzerman, Thomas J M Michiels, Marjolein Soethoudt, Xue Yang, Niek Dekker, Coen de Jong, Mario van der Stelt
Publikováno v:
Journal of Medicinal Chemistry, 61(17), 7892-7901. AMER CHEMICAL SOC
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Using activity-based protein profiling (ABPP), functional proteins can be interrogated in their native environment. Despite their pharmaceutical relevance, G protein-coupled receptors (GPCRs) have been difficult to address through ABPP. In the curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f443b4052b33998d24be7efdee3854
https://hdl.handle.net/1887/67709
https://hdl.handle.net/1887/67709
Autor:
Xue, Yang, Thomas J M, Michiels, Coen, de Jong, Marjolein, Soethoudt, Niek, Dekker, Euan, Gordon, Mario, van der Stelt, Laura H, Heitman, Daan, van der Es, Adriaan P, IJzerman
Publikováno v:
Journal of medicinal chemistry. 61(17)
Using activity-based protein profiling (ABPP), functional proteins can be interrogated in their native environment. Despite their pharmaceutical relevance, G protein-coupled receptors (GPCRs) have been difficult to address through ABPP. In the curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3e37dd9c800194409981404a44975b3
https://pubmed.ncbi.nlm.nih.gov/30080404
https://pubmed.ncbi.nlm.nih.gov/30080404
Autor:
Thomas J M Michiels, Laura H. Heitman, Xue Yang, Julien Louvel, Ad P. IJzerman, Eelke B. Lenselink, Guo Dong
Publikováno v:
Purinergic signalling, 13(2), 191-201
Purinergic Signalling, 13(2), 191-201. SPRINGER
Purinergic Signalling, 13(2), 191-201
Purinergic signalling
Purinergic Signalling, 13(2), 191-201. SPRINGER
Purinergic Signalling, 13(2), 191-201
Purinergic signalling
The structure of the human A2A adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a starting point for the incorporation of reactive mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313d0b8828eaed6bc6f96956526f217f
https://hdl.handle.net/1887/64259
https://hdl.handle.net/1887/64259
Autor:
Xue, Yang, Guo, Dong, Thomas J M, Michiels, Eelke B, Lenselink, Laura, Heitman, Julien, Louvel, Ad P, IJzerman
Publikováno v:
Purinergic Signalling
The structure of the human A2A adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a starting point for the incorporation of reactive mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cb949b42c226f9d6338cbdd6dd0b47c
https://pubmed.ncbi.nlm.nih.gov/27915383
https://pubmed.ncbi.nlm.nih.gov/27915383