Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Thomas J Lynch"'
Autor:
Vitaly Ievlev, Albert C. Pai, Drew S. Dillon, Spencer Kuhl, Thomas J. Lynch, Kyle W. Freischlag, Caitlyn B. Gries, John F. Engelhardt, Kalpaj R. Parekh
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
The field of airway biology research relies primarily on in vitro and in vivo models of disease and injury. The use of ex vivo models to study airway injury and cell-based therapies remains largely unexplored although such models have the potential t
Externí odkaz:
https://doaj.org/article/93e055f61a2548cc8dc2449b72fa86ca
Autor:
Vitaly Ievlev, Thomas J. Lynch, Kyle W. Freischlag, Caitlyn B. Gries, Anit Shah, Albert C. Pai, Bethany A. Ahlers, Soo Park, John F. Engelhardt, Kalpaj R. Parekh
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Keratin expression dynamically changes in airway basal cells (BCs) after acute and chronic injury, yet the functional consequences of these changes on BC behavior remain unknown. In bronchiolitis obliterans (BO) after lung transplantation, BC clonoge
Externí odkaz:
https://doaj.org/article/41b3b376fc304f71ba0d9cc56f256601
Autor:
Albert C. Pai, Anthony M. Swatek, Thomas J. Lynch, Bethany A. Ahlers, Vitaly Ievlev, John F. Engelhardt, Kalpaj R. Parekh
Publikováno v:
Bioengineering, Vol 10, Iss 7, p 777 (2023)
Tracheal grafts may be necessary to bridge long-segment defects after curative resection for airway obstructions. Bioengineered grafts have emerged as an appealing option, given the possibilities of altering the histologic and cellular profile of the
Externí odkaz:
https://doaj.org/article/f0fe2d53991c4de8ad9e85db54e5251a
Autor:
Albert C. Pai, Thomas J. Lynch, Bethany A. Ahlers, Vitaly Ievlev, John F. Engelhardt, Kalpaj R. Parekh
Publikováno v:
Cells, Vol 11, Iss 6, p 1027 (2022)
Tracheal grafts introduce the possibility to treat airway pathologies that require resection. While there has been success with engraftment of the surface airway epithelium (SAE) onto decellularized tracheas, there has been minimal advancement in reg
Externí odkaz:
https://doaj.org/article/c519b1dfe17c45239523f7e75b220530
Autor:
Thomas J. Lynch, Bethany A. Ahlers, Anthony M. Swatek, Vitaly Ievlev, Albert C. Pai, Leonard Brooks, Yinghua Tang, Idil A. Evans, David K. Meyerholz, John F. Engelhardt, Kalpaj R. Parekh
Publikováno v:
Transplantation. 106(10)
Long-term survival after lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). CLAD has 2 histologic phenotypes, namely obliterative bronchiolitis (OB) and restrictive alveolar fibroelastosis (AFE), which have distinct cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58502334bea6f08b106020220f48b6ab
https://pubmed.ncbi.nlm.nih.gov/35442243
https://pubmed.ncbi.nlm.nih.gov/35442243
Autor:
Parekh, Albert C. Pai, Anthony M. Swatek, Thomas J. Lynch, Bethany A. Ahlers, Vitaly Ievlev, John F. Engelhardt, Kalpaj R.
Publikováno v:
Bioengineering; Volume 10; Issue 7; Pages: 777
Tracheal grafts may be necessary to bridge long-segment defects after curative resection for airway obstructions. Bioengineered grafts have emerged as an appealing option, given the possibilities of altering the histologic and cellular profile of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e6dda19cbeec64cc43ea70dad8020560
Autor:
Thomas J. Lynch, Katerina Politi
Related Article from Two Sides of the Same Coin: EGFR Exon 19 Deletions and Insertions in Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04059e9a7f3668d908259608776fb137
https://doi.org/10.1158/1078-0432.22452473
https://doi.org/10.1158/1078-0432.22452473
Autor:
Thomas J. Lynch, Katerina Politi
Most lung adenocarcinoma-associated EGF receptor (EGFR) mutations confer sensitivity to specific EGFR tyrosine kinase inhibitors. The finding that exon 19 insertion mutations are also sensitive to this class of drugs suggests that testing for these m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4fad7e21c133a0e95a85da53a2980
https://doi.org/10.1158/1078-0432.c.6522488
https://doi.org/10.1158/1078-0432.c.6522488
Autor:
Kyle Freischlag, Thomas J. Lynch, Vitaly Ievlev, Caitlyn Gries, John C. Keech, Evgeny V. Arshava, Tahuanty Pena, Julia A. Klesney-Tait, Kalpaj R. Parekh
Publikováno v:
The Annals of thoracic surgery.
Lung transplantation is an acceptable and potentially life-saving treatment option for coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome and pulmonary fibrosis. This study was conducted to determine whether recipients of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6595b3a795bb78e8f7cc9208e45ff68
https://pubmed.ncbi.nlm.nih.gov/36228676
https://pubmed.ncbi.nlm.nih.gov/36228676
Autor:
Vitaly Ievlev, Chandler C Jensen-Cody, Thomas J Lynch, Albert C Pai, Soo Park, Weam Shahin, Kai Wang, Kalpaj R Parekh, John F Engelhardt
Publikováno v:
Stem Cells
Cartilaginous airways of larger mammals and the mouse trachea contain at least 3 well-established stem cell compartments, including basal cells of the surface airway epithelium (SAE) and ductal and myoepithelial cells of the submucosal glands (SMG).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3822a9b311ab5608b872e8d62c17f977
https://europepmc.org/articles/PMC9406614/
https://europepmc.org/articles/PMC9406614/