Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Thomas J Littlejohns"'
Autor:
Tian-Shin Yeh, Lei Clifton, Jennifer A. Collister, Xiaonan Liu, David J. Hunter, Thomas J. Littlejohns
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Associations between kidney function and dementia risk are inconclusive. Chronic kidney disease (CKD) severity is determined by levels of both estimated glomerular filtration rate (eGFR) and the urine albumin to creatinine ratio (
Externí odkaz:
https://doaj.org/article/fabf0705c6f942aaa3c8975433bbbc7b
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract We aimed to identify potential novel predictors for breast cancer among post-menopausal women, with pre-specified interest in the role of polygenic risk scores (PRS) for risk prediction. We utilised an analysis pipeline where machine learnin
Externí odkaz:
https://doaj.org/article/0ff92837e5af4712a198157c4da549c2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Polygenic risk scores (PRS) are proposed for use in clinical and research settings for risk stratification. However, there are limited investigations on how different PRS diverge from each other in risk prediction of individuals. We compared
Externí odkaz:
https://doaj.org/article/4e1eeb4a061f41ef85a40e780467bb67
Autor:
Alexander J. Mentzer, Nicole Brenner, Naomi Allen, Thomas J. Littlejohns, Amanda Y. Chong, Adrian Cortes, Rachael Almond, Michael Hill, Simon Sheard, Gil McVean, UKB Infection Advisory Board, Rory Collins, Adrian V. S. Hill, Tim Waterboer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here, the authors design a multiplex serology platform to quantitatively measure antibodies against 20 infectious agents in UK Biobank participants and confirm associations of antibody responses with sociodemographic characteristics, HLA genetic vari
Externí odkaz:
https://doaj.org/article/086909a39d6a4b8bbe11b080ee7709f7
Autor:
Xin You Tai, MBBS, Michele Veldsman, PhD, Donald M Lyall, PhD, Thomas J Littlejohns, PhD, Kenneth M Langa, ProfMD PhD, Masud Husain, ProfDPhil, Janice Ranson, PhD, David J Llewellyn, ProfPhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 3, Iss 6, Pp e428-e436 (2022)
Summary: Background: Individual cardiometabolic disorders and genetic factors are associated with an increased dementia risk; however, the relationship between dementia and cardiometabolic multimorbidity is unclear. We investigated whether cardiometa
Externí odkaz:
https://doaj.org/article/4cad11372e3b48df935818fce5519fe5
Autor:
Thomas J. Littlejohns, Jo Holliday, Lorna M. Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy D. Bell, Chris Boultwood, Rory Collins, Megan C. Conroy, Nicola Crabtree, Nicola Doherty, Alejandro F. Frangi, Nicholas C. Harvey, Paul Leeson, Karla L. Miller, Stefan Neubauer, Steffen E. Petersen, Jonathan Sellors, Simon Sheard, Stephen M. Smith, Cathie L. M. Sudlow, Paul M. Matthews, Naomi E. Allen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imagin
Externí odkaz:
https://doaj.org/article/73e20f652a8f4d1ab27778b09ca6f1bd
Autor:
Lorna M Gibson, John Nolan, Thomas J Littlejohns, Edouard Mathieu, Steve Garratt, Nicola Doherty, Steffen Petersen, Nicholas C W Harvey, Jonathan Sellors, Naomi E Allen, Joanna M Wardlaw, Caroline A Jackson, Cathie L M Sudlow
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218267 (2019)
BackgroundFeedback of potentially serious incidental findings (PSIFs) to imaging research participants generates clinical assessment in most cases. Understanding the factors associated with increased risks of PSIFs and of serious final diagnoses may
Externí odkaz:
https://doaj.org/article/d03d88cd46a84ed4ac6204b704a89713
Autor:
Thomas J. Littlejohns, Jennifer A. Collister, Xiaonan Liu, Lei Clifton, Neo M. Tapela, David J. Hunter
Publikováno v:
Alzheimer's & Dementia. 19:467-476
Introduction There is inconsistent evidence on whether genetic risk for dementia modifies the association between hypertension and dementia. Methods In 198,965 dementia-free participants aged ≥60 years, Cox proportional-hazards models were used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38bc989b6261b8727de2b0102a3229f
https://doi.org/10.1002/alz.12680
https://doi.org/10.1002/alz.12680
Autor:
Xin You Tai, Michele Veldsman, Donald M Lyall, Thomas J Littlejohns, Kenneth M Langa, Masud Husain, Janice M Ranson, David J Llewellyn
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca55b524f84eec20eb47ea3c1db7cdf
https://doi.org/10.1002/alz.067990
https://doi.org/10.1002/alz.067990
Autor:
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow
Publikováno v:
Wellcome Open Research, Vol 2 (2018)
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging. We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 partici
Externí odkaz:
https://doaj.org/article/b3c06e9180fc40be829e46abee92be40