Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Thomas J Kunicki"'
Autor:
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e114035 (2014)
Platelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models. Previous studies of GPV
Externí odkaz:
https://doaj.org/article/a0186060a2c64848bb49810c27afac21
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55094 (2013)
We have engineered a transgenic mouse on a C57BL/6 background that bears a floxed Itga2 gene. The crossing of this mouse strain to transgenic mice expressing Cre recombinase driven by the megakaryocyte (MK)-specific Pf4 promoter permits the condition
Externí odkaz:
https://doaj.org/article/c9f4b98311de41c1aafd3b468cb9b9ed
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8743 (2010)
We have identified a cytosine-adenosine (CA) repeat length polymorphism in the 5'-regulatory region of the human integrin alpha2 gene ITGA2 that begins at -605. Our objective was to establish the contribution of this polymorphism to the regulation of
Externí odkaz:
https://doaj.org/article/3877c385d80d462b9c801a5c78f333fc
Publikováno v:
Haematologica, Vol 97, Iss 5 (2012)
A single nucleotide polymorphism in the integrin α2 gene ITGA2 (rs1801106; G1600A) creates the non-conservative amino acid substitution E534K, the basis of the human platelet alloantigen system HPA-5. Yet HPA-5 alleles do not influence binding of α
Externí odkaz:
https://doaj.org/article/995ed3eaa43049748824f47bada6a7e6
Publikováno v:
Inflammation Research. 63:299-308
Variable tissue factor (TF) expression by human microvascular endothelial cells (HMVEC) may be regulated by two promoter haplotypes, distinguished by an 18-basepair deletion (D) or insertion (I) at −1,208. We sought to determine the relationship be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142ac6a0bcd44b3846e070f96e33ca13
https://doi.org/10.1007/s00011-013-0701-5
https://doi.org/10.1007/s00011-013-0701-5
Autor:
Diane J. Nugent, Thomas J. Kunicki
Publikováno v:
Platelets. 28(1)
Taken together, there is ample evidence of the association of cardiovascular disease, cerebrovascular, and inflammatory disease with single nucleotide variants (SNV) due to their impact on platelet size, number, and function. With the use of electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c634c5d6896893f3500bd0e47086a8
https://pubmed.ncbi.nlm.nih.gov/28032522
https://pubmed.ncbi.nlm.nih.gov/28032522
Publikováno v:
Current Opinion in Hematology. 19:371-379
This review summarizes our current knowledge of common gene variants (polymorphisms) that have small individual effects on platelet function in humans, but can cumulatively lead to hyperreactive platelets and increase risk for negative outcomes in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9de589377e10c411f7f81d95bccabdf
https://doi.org/10.1097/moh.0b013e3283567526
https://doi.org/10.1097/moh.0b013e3283567526
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:147-152
Objective— The interindividual variation in platelet α 2 β 1 exceeds a 2-fold variance in platelet α IIb β 3 level. Our objective was to parse the contribution of mean platelet volume (MPV) and integrin gene alleles to this variation in large c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9726fe5a0339805062162ec067307475
https://doi.org/10.1161/atvbaha.111.239392
https://doi.org/10.1161/atvbaha.111.239392
Autor:
Daniel R. Salomon, Thomas J. Kunicki, Paul Harrison, Shirley A. Williams, Steven R. Head, Diane J. Nugent, Peggy Nakagawa, Tony S. Mondala, P. Crisler
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:2116-2122
Summary. Background: The Platelet Function Analyzer-100 (PFA-100) is widely used to measure platelet reactivity in whole blood under high shear. Objective: To characterize the genetic component of platelet reactivity among normal individuals, using t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9c24cef09153e61fa1327891999608
https://doi.org/10.1111/j.1538-7836.2009.03610.x
https://doi.org/10.1111/j.1538-7836.2009.03610.x
Autor:
Mario Mazzucato, Zaverio M. Ruggeri, Monica Battiston, Maria Rita Cozzi, Luigi De Marco, Martine Jandrot-Perrus, Patrizia Marchese, Maurizio Mongiat, Thomas J. Kunicki
Publikováno v:
Blood. 114:2793-2801
We studied how integrin alpha2beta1 and glycoprotein VI (GPVI) contribute to collagen-induced platelet activation under flow conditions by evaluating stable adhesion and intracellular Ca(2+) concentration ([Ca(2+)](i)) of FLUO 3-AM-labeled platelets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385131a6e5d35c632da8659c261eee85
https://doi.org/10.1182/blood-2008-12-193490
https://doi.org/10.1182/blood-2008-12-193490