Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Thomas J Kean"'
Autor:
Fei Wei, Megan Hughes, Mahmoud Omer, Christopher Ngo, Abinaya Sindu Pugazhendhi, Elayaraja Kolanthai, Matthew Aceto, Yasmine Ghattas, Mehdi Razavi, Thomas J Kean, Sudipta Seal, Melanie Coathup
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract By 2060, an estimated one in four Americans will be elderly. Consequently, the prevalence of osteoporosis and fragility fractures will also increase. Presently, no available intervention definitively prevents or manages osteoporosis. This st
Externí odkaz:
https://doaj.org/article/69a62f2fff1b4571841a906a538ee2d2
Autor:
Thomas J Kean, James E Dennis
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138409 (2015)
Externí odkaz:
https://doaj.org/article/37b179d7948041848579456e4cc7099b
Autor:
Thomas J Kean, James E Dennis
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129961 (2015)
Current tissue engineering methods are insufficient for total joint resurfacing, and chondrocytes undergo de-differentiation when expanded on tissue culture plastic. De-differentiated chondrocytes show poor re-differentiation in culture, giving reduc
Externí odkaz:
https://doaj.org/article/ed7a72fc652c4bb484da2eb18453e597
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Improving the ability of human chondrocytes to proliferate, while maintaining their differentiation potential, has presented a great challenge in cartilage tissue engineering. In this study, human chondrocytes were cultured under four unique growth c
Externí odkaz:
https://doaj.org/article/8f1e6c6cf5ce4e229b0203c3d6d540b6
Autor:
Kari Martyniak, Alesia Lokshina, Maria A. Cruz, Makan Karimzadeh, Rachel Kemp, Thomas J. Kean
Publikováno v:
Acta Biomaterialia. 152:221-234
Gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA) are frequently used biomaterials for 3D bioprinting, with individual well-established material characteristics. To identify an ideal combination of GelMA and HAMA for chondrogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f52dcb9665cde736f8b96d524b21d9
https://doi.org/10.1016/j.actbio.2022.08.058
https://doi.org/10.1016/j.actbio.2022.08.058
Autor:
Thomas J. Kean
Publikováno v:
Journal of Orthopedics and Orthopedic Surgery. 4:10-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b529f20badbfc857835435bdf6066b
https://doi.org/10.29245/2767-5130/2023/1.1172
https://doi.org/10.29245/2767-5130/2023/1.1172
Osteoarthritis is a significant and growing problem with no disease modifying drugs in the clinic. Current screening platforms typically use 2D culture, immortalized or non-human cells in a hyperoxic environment. To challenge this paradigm and identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90fc94c3015f70acf18f2c987ebc90cb
https://doi.org/10.1101/2023.03.10.532073
https://doi.org/10.1101/2023.03.10.532073
Autor:
Maria A. Cruz, Yamilet Gonzalez, Javier A. Vélez Toro, Makan Karimzadeh, Anthony Rubbo, Lauren Morris, Ramapaada Medam, Taylor Splawn, Marilyn Archer, Russell J. Fernandes, James E. Dennis, Thomas J. Kean
Tissue Engineering of cartilage has been hampered by the inability of engineered tissue to express native levels of type II collagenin vitro. Inadequate levels of type II collagen are, in part, due to a failure to recapitulate the physiological envir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78ce2f87076ac3ff3974ac387fcfa7b2
https://doi.org/10.1101/2022.12.07.519522
https://doi.org/10.1101/2022.12.07.519522
Autor:
Nadia Aboutalebianaraki, Peter Zeblisky, M. D. Sarker, Aadithya Jeyaranjan, Tamil S. Sakthivel, Yifei Fu, John Lucchi, Matthieu Baudelet, Sudipta Seal, Thomas J. Kean, Mehdi Razavi
Publikováno v:
Journal of biomedical materials research. Part AREFERENCES.
The aim of this study was to develop a novel biodegradable magnesium (Mg) alloy for bone implant applications. We used scandium (Sc; 2 wt %) and strontium (Sr; 2 wt %) as alloying elements due to their high biocompatibility, antibacterial efficacy, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff43996de0f8f55b4ea004a84f7ea84
https://pubmed.ncbi.nlm.nih.gov/36494895
https://pubmed.ncbi.nlm.nih.gov/36494895
Autor:
Rachel L. Pan, Kari Martyniak, Makan Karimzadeh, David G. Gelikman, Jonathan DeVries, Kelly Sutter, Melanie Coathup, Mehdi Razavi, Rajendra Sawh-Martinez, Thomas J. Kean
Publikováno v:
Journal of experimental orthopaedics. 9(1)
Background Joint degeneration and large or complex bone defects are a significant source of morbidity and diminished quality of life worldwide. There is an unmet need for a functional implant with near-native biomechanical properties. The potential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd4662caaae409fa94dcae71b020b96
https://pubmed.ncbi.nlm.nih.gov/36121526
https://pubmed.ncbi.nlm.nih.gov/36121526