Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Thomas J J, Müller"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2024-2077 (2024)
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications. The search for new an
Externí odkaz:
https://doaj.org/article/c4c8dfdcb1e64ce09a7f54cae8329d37
Autor:
Laura Schmitt, Julia Hoppe, Pablo Cea-Medina, Peter-Martin Bruch, Karina S. Krings, Ilka Lechtenberg, Daniel Drießen, Christoph Peter, Sanil Bhatia, Sascha Dietrich, Björn Stork, Gerhard Fritz, Holger Gohlke, Thomas J. J. Müller, Sebastian Wesselborg
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract A key feature of cancer is the disruption of cell cycle regulation, which is characterized by the selective and abnormal activation of cyclin-dependent kinases (CDKs). Consequently, targeting CDKs via meriolins represents an attractive thera
Externí odkaz:
https://doaj.org/article/63272546db6a4c5fbc60190ad36400b2
Autor:
Lukas Biesen, Thomas J. J. Müller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Using the established synthetic methods, aroyl-S,N-ketene acetals and subsequent bi- and multichromophores can be readily synthesized. Aside from pronounced AIE (aggregation induced emission) properties, these selected examples possess disti
Externí odkaz:
https://doaj.org/article/d090e06815944dc880d3b920cd4bf86d
Autor:
Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) that displayed a strong apoptotic potential in Jurkat l
Externí odkaz:
https://doaj.org/article/bb0b5a2076ab4d3192f705aa5b86dbd2
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1379-1385 (2023)
A library of 19 differently substituted 3-iodoindoles is generated by a consecutive four-component reaction starting from ortho-haloanilines, terminal alkynes, N-iodosuccinimide, and alkyl halides in yields of 11–69%. Initiated by a copper-free alk
Externí odkaz:
https://doaj.org/article/7e03169d460d4705861c461fb9f4dff2
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Alkynylated aroyl-S,N-ketene acetals are readily synthesized in mostly excellent yields by a Sonogashira reaction resulting in a substance library of more than 20 examples. Upon expansion of the reaction sequence by deprotection and concaten
Externí odkaz:
https://doaj.org/article/d0a1cf6dbf324576b1bd26fbae36bd18
Publikováno v:
Organics, Vol 4, Iss 3, Pp 313-332 (2023)
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction. In this study, the aza-Michael addition step to generate intermediate enam
Externí odkaz:
https://doaj.org/article/390b8fb80dc74f94b0bbebb528e89d10
Publikováno v:
Molecules, Vol 29, Iss 9, p 2126 (2024)
In this study, a library of 3,7-di(hetero)aryl-substituted 10-(3-trimethylammoniumpropyl)10H-phenothiazine salts is prepared. These title compounds and their precursors are reversible redox systems with tunable potentials. The Hammett correlation giv
Externí odkaz:
https://doaj.org/article/f0bccf511c164519a6e2abc67fb96290
Autor:
Thibault Gendron, Don Antoine Lanfranchi, Nicole I. Wenzel, Hripsimée Kessedjian, Beate Jannack, Louis Maes, Sandrine Cojean, Thomas J. J. Müller, Philippe M. Loiseau, Elisabeth Davioud-Charvet
Publikováno v:
Molecules, Vol 29, Iss 7, p 1620 (2024)
2,6-Diaryl-4H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones through a prodrug effect. Novel diastereoselective methodo
Externí odkaz:
https://doaj.org/article/65239637fac74e389deee1c922309e2e
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/e07c8839339d4530bf75c5e4e1bfc9ce