Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Thomas J Hund"'
Autor:
Cheng-Hsin Liu, Ryan Seo, Tammy Szu-Yu Ho, Michael Stankewich, Peter J Mohler, Thomas J Hund, Jeffrey L Noebels, Matthew N Rasband
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na+ channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS)
Externí odkaz:
https://doaj.org/article/b0a80c607d4b4ee5b9e6ed64b25767e2
Autor:
Cheng-Hsin Liu, Sharon R Stevens, Lindsay H Teliska, Michael Stankewich, Peter J Mohler, Thomas J Hund, Matthew N Rasband
Publikováno v:
eLife, Vol 9 (2020)
Clustered ion channels at nodes of Ranvier are critical for fast action potential propagation in myelinated axons. Axon-glia interactions converge on ankyrin and spectrin cytoskeletal proteins to cluster nodal Na+ channels during development. However
Externí odkaz:
https://doaj.org/article/8c24ae03c00e485d8d2d3fd446f61a16
Publikováno v:
Cells, Vol 10, Iss 6, p 1516 (2021)
The voltage-gated Na+ channel Nav1.5 is critical for normal cardiac myocyte excitability. Mathematical models have been widely used to study Nav1.5 function and link to a range of cardiac arrhythmias. There is growing appreciation for the importance
Externí odkaz:
https://doaj.org/article/441351a248df4b25a6fb400250e6da18
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Post-translational modification of membrane proteins (e.g. ion channels, receptors) by protein kinases is an essential mechanism for control of excitable cell function. Importantly, loss of temporal and/or spatial control of ion channel post-translat
Externí odkaz:
https://doaj.org/article/a74a88d2684e40e78b13e13a6a48eb3e
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89049 (2014)
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium. Sinoatrial node dysfunction, characterized by slow and/or asynchronous pace
Externí odkaz:
https://doaj.org/article/67f83efc4d16428e88c745cf7d40bdd2
Autor:
Arnold Vreeker, Leonie van Stuijvenberg, Thomas J Hund, Peter J Mohler, Peter G J Nikkels, Toon A B van Veen
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94722 (2014)
In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provides as a macromolecular infrastructure that integrates mechanical and electrical coupling within the heart. Pathophysiological disturbance in composit
Externí odkaz:
https://doaj.org/article/641b9bcee89c42a5833b01df0cb7a22d
Autor:
Kelsey M. Pinckard, Elisa Félix-Soriano, Shanna Hamilton, Radmila Terentyeva, Lisa A. Baer, Katherine R. Wright, Drew Nassal, Joao Victor Esteves, Eaman Abay, Vikram K. Shettigar, Mark T. Ziolo, Thomas J. Hund, Loren E. Wold, Dmitry Terentyev, Kristin I. Stanford
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101914- (2024)
Objective: The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease in offspring. Maternal exercise prevents the detrimental effects of a maternal high fat diet on the meta
Externí odkaz:
https://doaj.org/article/43233158c48a4f618c81e1532dc8152a
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78087 (2013)
Cardiac Na channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart. Recent studies show that Nav1.5 assembly and function are linked to ankyrin-G, gap, and mechanical junc
Externí odkaz:
https://doaj.org/article/0a5405f05cf849acac5e999daa014736
Autor:
Aaron D. Argall, Holly C. Sucharski-Argall, Luke G. Comisford, Sallie J. Jurs, Jack T. Seminetta, Michael J. Wallace, Casey A. Crawford, Sarah S. Takenaka, Mei Han, Mona El Refaey, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8403 (2024)
Altered ankyrin-R (AnkR; encoded by ANK1) expression is associated with diastolic function, left ventricular remodeling, and heart failure with preserved ejection fraction (HFpEF). First identified in erythrocytes, the role of AnkR in other tissues,
Externí odkaz:
https://doaj.org/article/788ff8b6db97434b9710c167319a61c4
Autor:
Matthew D Christensen, Wen Dun, Penelope A Boyden, Mark E Anderson, Peter J Mohler, Thomas J Hund
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 12, p e1000583 (2009)
Calmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Dysfunction in the CaMKII signaling pathway occurs in heart disease and is assoc
Externí odkaz:
https://doaj.org/article/0262aead4d844d6b9cfe94d9bc14eefd