Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Thomas J Hawke"'
Autor:
Irena A Rebalka, Kenneth S Noguchi, Kayla R Bulyovsky, Matthew I Badour, Emma S Juracic, Khandra Barrett, Aditya Brahmbhatt, Baraa Al-Khazraji, Zubin Punthakee, Christopher G R Perry, Dinesh A Kumbhare, Maureen J MacDonald, Thomas J Hawke
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303448 (2024)
IntroductionIndividuals with type 1 diabetes (T1D) experience a complex set of alterations to skeletal muscle metabolic, neuromuscular, and vascular health; collectively referred to as diabetic myopathy. While the full scope of diabetic myopathy is s
Externí odkaz:
https://doaj.org/article/be2d1b9fe331491b83c11ea6c275fa47
Autor:
Irena A Rebalka, Matthew J Raleigh, Laelie A Snook, Alexandra N Rebalka, Rebecca EK MacPherson, David C Wright, Jonathan D Schertzer, Thomas J Hawke
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
While statins significantly reduce cholesterol levels and thereby reduce the risk of cardiovascular disease, the development of myopathy with statin use is a significant clinical side-effect. Recent guidelines recommend increasing inclusion criteria
Externí odkaz:
https://doaj.org/article/3ee13a09d08c48dd978a91d98abcdee5
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Diabetes mellitus is defined as a group of metabolic diseases that are associated with the presence of a hyperglycemic state due to impairments in insulin function. While the development of each form of diabetes (Type 1 or Type 2) drastically differs
Externí odkaz:
https://doaj.org/article/ba96f6f68ac14faa9fd3f75b9edce0ea
Autor:
Karin E Trajcevski, Hayley M O'Neill, David C Wang, Melissa M Thomas, Dhuha Al-Sajee, Gregory R Steinberg, Rolando B Ceddia, Thomas J Hawke
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71747 (2013)
BACKGROUND: Diet-induced obesity is a rising health concern which can lead to the development of glucose intolerance and muscle insulin resistance and, ultimately, type II diabetes mellitus. This research investigates the associations between glucose
Externí odkaz:
https://doaj.org/article/ac5b17fce1f7476da14d442dfa18d386
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84451 (2013)
Mouse and rat skeletal muscles are capable of a regulatory volume increase (RVI) after they shrink (volume loss resultant from exposure to solutions of increased osmolarity) and that this RVI occurs mainly by a Na-K-Cl-Cotransporter (NKCC)-dependent
Externí odkaz:
https://doaj.org/article/28ad55509970422ebbac4d9ae3bdff87
Autor:
Matthew P Krause, Dhuha Al-Sajee, Donna M D'Souza, Irena A Rebalka, Jasmin Moradi, Michael C Riddell, Thomas J Hawke
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70971 (2013)
Systemic elevations in PAI-1 suppress the fibrinolytic pathway leading to poor collagen remodelling and delayed regeneration of tibialis anterior (TA) muscles in type-1 diabetic Akita mice. However, how impaired collagen remodelling was specifically
Externí odkaz:
https://doaj.org/article/566c928d8d5346d39d79760e8a2dfefd
Autor:
Carly S Gordon, Antonio S Serino, Matthew P Krause, Jonathan E Campbell, Enzo Cafarelli, Olasunkanmi A J Adegoke, Thomas J Hawke, Michael C Riddell
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14032 (2010)
This present study investigated the temporal effects of type 1 diabetes mellitus (T1DM) on adolescent skeletal muscle growth, morphology and contractile properties using a 90% partial pancreatecomy (Px) model of the disease. Four week-old male Spragu
Externí odkaz:
https://doaj.org/article/cfb4486c8ab54554a546e7fa49aa5dc0
Autor:
Karin E Shortreed, Matthew P Krause, Julianna H Huang, Dili Dhanani, Jasmin Moradi, Rolando B Ceddia, Thomas J Hawke
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7293 (2009)
BACKGROUND:The effects of diet-induced obesity on skeletal muscle function are largely unknown, particularly as it relates to changes in oxidative metabolism and morphology. PRINCIPAL FINDINGS:Compared to control fed mice, mice fed a high fat diet (H
Externí odkaz:
https://doaj.org/article/ff0165ce0cba4332b3a0b1a35f864bed
Autor:
Tiffany L. vanLieshout, Derek W. Stouth, Nicolas G. Hartel, Goutham Vasam, Sean Y. Ng, Erin K. Webb, Irena A. Rebalka, Andrew I. Mikhail, Nicholas A. Graham, Keir J. Menzies, Thomas J. Hawke, Vladimir Ljubicic
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101555- (2022)
Objective: Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of arginine residues on target proteins to regulate critical processes in health and disease. A mechanistic understanding of the role(s) of CARM1 in skel
Externí odkaz:
https://doaj.org/article/7c648c6bb9d546ceae939e35a8abb2f3
Publikováno v:
Journal of Diabetes Research, Vol 2022 (2022)
Type 1 diabetes is associated with complications affecting muscle and bone, with diabetic bone disease and diabetic myopathy becoming increasingly reported in the past few decades. This review is aimed at succinctly reviewing the literature on the cu
Externí odkaz:
https://doaj.org/article/17dd8cf2c8644ac28eccaf7a674c0ae0